Decoding Roles of Exosomal lncRNAs in Tumor-Immune Regulation and Therapeutic Potential

Zhang, Wenqin; Yan, Yuanliang; Peng, Jinwu; Thakur, Abhimanyu; Bai, Ning; Yang, Keda; Xu, Zhijie

doi:10.3390/cancers15010286

Cited by 21 publications

(6 citation statements)

References 128 publications

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“…In particular, several studies have focused on the interaction between cancer cells and immune cells that have infiltrated the tumor microenvironment, and how exosomal lncRNAs mediate this process. Tumor-derived exosomal lncRNAs appear to boost M2 macrophage polarization and inhibit the function of natural killer cells in vitro, thus supporting tumor progression (76). Exosomes can potentially provide a link between early-life development and cancer in adult life.…”

Section: Exosomes and Epigenetic Regulationmentioning

confidence: 99%

Influence of epigenetics and microbiota in early‑life development: A possible role for exosomes (Review)

Mitsis,

Papakonstantinou,

Dragoumani

et al. 2024

Int J Epigen

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Early-life development has a direct effect on the long-term health of an individual. some of the main processes influencing early-life development are epigenetic modifications, i.e., mechanisms that promote changes in gene expression in the context of the same DNA sequence, and changes in the human microbiota, i.e., living organisms located on or within humans with prime examples being the human microorganisms located in the human gastrointestinal system. These processes can be mediated by extracellular vesicles, which are essential agents of cell-to-cell communications. Exosomes, a subgroup of extracellular vesicles, are of particular interest in early life, since they have been shown to be associated with the development of infant immune response, neuronal function and metabolism. The present review summarizes the latest literature on the effects of epigenetic modifications and microbiota changes in early-life development, and discusses the mechanisms through which exosomes may mediate such changes. A special mention is also made to human breast milk, since several of the benefits associated with breast feeding could be potentially linked with the microbiota and the exosomes it contains.

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Section: Exosomes and Epigenetic Regulationmentioning

confidence: 99%

Influence of epigenetics and microbiota in early‑life development: A possible role for exosomes (Review)

Mitsis,

Papakonstantinou,

Dragoumani

et al. 2024

Int J Epigen

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“…They can potentially instigate the transformation of normal cells into malignant ones [ 30 , 31 , 32 ]. Moreover, lncRNAs significantly shape the anti-tumor immune landscape by interacting with DNA, RNA, and proteins and by modulating the expression of immune response genes [ 33 ].…”

Section: The Fundamentals Of Long Non-coding Rnasmentioning

confidence: 99%

Long Non-Coding RNAs in Colorectal Cancer: Navigating the Intersections of Immunity, Intercellular Communication, and Therapeutic Potential

Shakhpazyan,

Mikhaleva,

Bedzhanyan

et al. 2023

Biomedicines

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This comprehensive review elucidates the intricate roles of long non-coding RNAs (lncRNAs) within the colorectal cancer (CRC) microenvironment, intersecting the domains of immunity, intercellular communication, and therapeutic potential. lncRNAs, which are significantly involved in the pathogenesis of CRC, immune evasion, and the treatment response to CRC, have crucial implications in inflammation and serve as promising candidates for novel therapeutic strategies and biomarkers. This review scrutinizes the interaction of lncRNAs with the Consensus Molecular Subtypes (CMSs) of CRC, their complex interplay with the tumor stroma affecting immunity and inflammation, and their conveyance via extracellular vesicles, particularly exosomes. Furthermore, we delve into the intricate relationship between lncRNAs and other non-coding RNAs, including microRNAs and circular RNAs, in mediating cell-to-cell communication within the CRC microenvironment. Lastly, we propose potential strategies to manipulate lncRNAs to enhance anti-tumor immunity, thereby underlining the significance of lncRNAs in devising innovative therapeutic interventions in CRC.

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“…Metastasis is stimulated and controlled by intercellular communication in endothelial cells [115]. By interfering with their direct and indirect communication mediators against endothelial changes, both stages can be inhibited [116]. There is a summary of twenty recent studies that have addressed metastasis with medicines that interfere with communication mediators in signalling pathways, as shown in Table 3.…”

Section: Interfere Communication Mediators' Therapiesmentioning

confidence: 99%

Relationship between Osteosarcoma Therapy and Tumorigenesis, Metastasis, Immune Evasion, and Chemoresistance

Zaidi¹,

Haque²,

Miskon³

2023

Preprint

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There has been no significant efficacy in treatment for osteosarcoma (OS) metastasis after nearly four decades of trials. This motivates us to elucidate OS therapies according to their four bidirectional mutation stages. To refresh the OS therapy status quo, the historical developments and clinical advancements are briefly described. However, the main issue of metastasis remains unresolved, accounting for 90% of pulmonary metastasis deaths. Thus, this metastasis problem is related to immune evasion and chemoresistance that are being induced after long-term treatment by the use of immunotherapy for tumorigenesis. Therefore, it is rationale to discuss the relationship cycles of mutation stages including tumorigenesis, metastasis, immune evasion, and chemoresistance. Even though many combinational and targeted therapies have been developed to intensify these mutation treatments, successful clinical translations with higher cure rates are still rare. Through this review, an in-depth understanding of the bidirectional relationship between the four OS mutation stages and their respective therapies is provided. Herein, we summarise the medicines used to treat tumorigenesis, including COLGALT2 inhibitors, Tra2B, and AGAP1, miR-148a and miR-21-5p EVs, and the lncRNA LIFR-AS1. Following the medicines used to treat metastasis are AXL, miR-135a-5p, mRNA BCL6, TGFβ1, Tim-3, SOCS5, CASC15, KLF3-AS1, PDCD4, ATG5, and Rab22a-NeoF1. Then the medicines used to treat immune evasion are N-cadherin, anti-IL-9, USP12 inhibitor, IgG-4+ B-cells, LAP inhibitor, anti-Wnt2 mAb, anti-αvβ8 integrin, HK2-mediated IκBα, IDO inhibitor with NO, and TGF-βRII with anti-IgG1. Finally, the medicines used to treat chemoresistance are DHFR, FPGS, HSP-90AA1, XCT-790, ATKI, and IGF1. As a result, this contribution is expected to serve as a reference and guide for scientists and clinicians.

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Decoding Roles of Exosomal lncRNAs in Tumor-Immune Regulation and Therapeutic Potential

Cited by 21 publications

References 128 publications

Influence of epigenetics and microbiota in early‑life development: A possible role for exosomes (Review)

Influence of epigenetics and microbiota in early‑life development: A possible role for exosomes (Review)

Long Non-Coding RNAs in Colorectal Cancer: Navigating the Intersections of Immunity, Intercellular Communication, and Therapeutic Potential

Relationship between Osteosarcoma Therapy and Tumorigenesis, Metastasis, Immune Evasion, and Chemoresistance

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