Decoding Skin Involvement in Chronic Graft-vs-Host Disease

Cowen, Edward W.

doi:10.1001/jamadermatol.2019.0354

Cited by 2 publications

(3 citation statements)

References 6 publications

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“…The remaining three SD patients (3,4,5) and the two cGVHD patients without skin manifestations (11, 12) had near zero regression slopes, consistent with clinical perception of stable status. Of note, patient 3 was receiving extracorporeal photopheresis (ECP) on a treatment schedule of 2 consecutive days every 4 weeks during the study.…”

Section: To the Editorsupporting

confidence: 55%

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Longitudinal tracking of skin dynamic stiffness to quantify evolution of sclerosis in chronic graft-versus-host disease

Baker

Chen

Ssempijja

et al. 2020

Bone Marrow Transplant

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Section: To the Editorsupporting

confidence: 55%

“…Skin sclerosis severely impairs quality of life and responds slowly to therapy [1]. The current gold standard for grading cGVHD sclerosis, the NIH skin score, is coarse and subjective [2], motivating calls for more reproducible measures [3].…”

Section: To the Editormentioning

confidence: 99%

Longitudinal tracking of skin dynamic stiffness to quantify evolution of sclerosis in chronic graft-versus-host disease

Baker

Chen

Ssempijja

et al. 2020

Bone Marrow Transplant

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“…Chronic graft-versus-host disease (GVHD) is the most frequent late complication of allogenic hematopoietic stem cell transplantation (ASCT) [ 5 ]. Skin is the most common organ affected (75%), with presentation of a large variety of lesions [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Eosinophilic fasciitis (Shulman syndrome), a rare entity and diagnostic challenge, as a manifestation of severe chronic graft-versus-host disease: a case report

et al. 2021

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Background Shulman’s disease, or eosinophilic fasciitis (EF), is a rare autoimmune disease, characterized by sclerodermic skin lesions with progressive induration and thickening of the soft tissues. Chronic graft-versus-host-disease (GVHD) presenting as EF is a very rare manifestation of cutaneous GVHD. Case presentation We report an unusual case of EF in a 46-year-old Caucasian male patient who had received an allogenic hematopoietic stem cell transplantation in the context of relapsed/refractory multiple myeloma. The diagnosis was challenging, with the patient presenting hepatic dysfunction, normal eosinophils count, and incomplete clinical signs. Magnetic resonance imaging (MRI) and skin biopsy confirmed the diagnosis of EF. Early initiation of specific treatment with corticosteroids and prednisolone achieved complete response. Conclusion In practice, incomplete signs in this rare complication should lead to MRI as it is a major tool to guide decision-making based on the skin biopsy, allowing a rapid diagnosis and the initiation of treatment without delay.

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Decoding Skin Involvement in Chronic Graft-vs-Host Disease

Cited by 2 publications

References 6 publications

Longitudinal tracking of skin dynamic stiffness to quantify evolution of sclerosis in chronic graft-versus-host disease

Longitudinal tracking of skin dynamic stiffness to quantify evolution of sclerosis in chronic graft-versus-host disease

Eosinophilic fasciitis (Shulman syndrome), a rare entity and diagnostic challenge, as a manifestation of severe chronic graft-versus-host disease: a case report

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