Decoding the mystery of how bacteria “talk”: Among Gram-negative microorganisms

Tan, Wen-Si; Law, Jodi Woan‐Fei; Letchumanan, Vengadesh; Chan, Kok‐Gan

doi:10.36877/pmmb.a0000038

Cited by 8 publications

(6 citation statements)

References 86 publications

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“…Quorum sensing refers to the process in which cells communicate by producing and detecting extracellular cell signalling molecules known as autoinducers (AI) and alter their gene expression in response to the cell population density [ 136 , 137 ]. It was first described in 1970 by Nealson, et al [ 138 ] when his research team discovered that the bioluminescent bacteria, Photobacterium fischeri, secreted the enzyme luciferase in a huge amount during a period of exponential bacterial growth.…”

Section: Alternative Methods For Animal Husbandrymentioning

confidence: 99%

Unveiling the Impact of Antibiotics and Alternative Methods for Animal Husbandry: A Review

et al. 2021

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Since the 1950s, antibiotics have been used in the field of animal husbandry for growth promotion, therapy and disease prophylaxis. It is estimated that up to 80% of the antibiotics produced by the pharmaceutical industries are used in food production. Most of the antibiotics are used as feed additives at sub-therapeutic levels to promote growth. However, studies show the indiscriminate use of antibiotics has led to the emergence of multidrug-resistant pathogens that threaten both animal health and human health, including vancomycin-resistant Enterococcus (VRE), Methicillin-resistant Staphylococcus aureus (MRSA) and carbapenem-resistant Enterobacteriaceae (CRE). This scenario is further complicated by the slow progress in achieving scientific breakthroughs in uncovering novel antibiotics following the 1960s. Most of the pharmaceutical industries have long diverted research funds away from the field of antibiotic discovery to more lucrative areas of drug development. If this situation is allowed to continue, humans will return to the pre-antibiotics era and potentially succumb to huge health and economic consequences. Fortunately, studies investigating various alternatives to antibiotics use in livestock show promising results. These alternatives include the application of bacteriophages and phage derived peptidoglycan degrading enzymes, engineered peptides, egg yolk antibodies, probiotics, prebiotics and synbiotics, as well as quorum quenching molecules. Therefore, this review aims to discuss the use of growth-promoting antibiotics and their impact on livestock and provide insights on the alternative approaches for animal husbandry.

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Section: Alternative Methods For Animal Husbandrymentioning

confidence: 99%

Unveiling the Impact of Antibiotics and Alternative Methods for Animal Husbandry: A Review

et al. 2021

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“…Thus, inhibiting bacterial QS could possibly become an antibacterial method, which can prevent the development of bacterial resistance and eradicate the expression of virulence factor genes (Tan et al . 2019b; Zhao et al . 2020).…”

Section: Conclusion and Future Perspectivementioning

confidence: 99%

Incidence of antibiotic resistance in Vibrio spp

Loo

Letchumanan

Law

et al. 2020

Reviews in Aquaculture

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Vibrio species is a common natural inhabitant of brackish and saltwater. Vibrio sp. includes not only emerging pathogens but also well‐known and emerged pathogens, such as V. cholerae, V. parahaemolyticus and V. vulnificus. Although it is often harmless, pathogenic strains which could cause serious food‐borne illnesses/outbreaks in both humans and animals have been identified. Vibrio infection is usually self‐limiting and requires no clinical treatment. However, antibiotics are still required to treat severe cases of Vibrio infection. Recent reports have highlighted a rise in the presence of antibiotic‐resistant Vibrio in the environment. This hampers the clinical treatment of Vibrio infection and has been linked to the imprudent use of antibiotics in various fields such as human medicine, agriculture and animal husbandry. As a result, it has greatly jeopardized food security, threatened public health and impugned the growth of economy. Food is a potential vehicle of antibiotic‐resistant Vibrio where the resistant genes are transmitted to humans via ingestion of contaminated food. Hence, the surveillance, monitoring and management of antibiotic patterns of Vibrio are important for clinical treatment. This review focuses on different trends and global patterns of antibiotic resistance of Vibrio.

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“…We also could adapt quorum sensing method to understand the various signalling molecules of Vibrio sp. These information are useful in the management of virulence traits [51] . In summary, the application of antibiotics in aquaculture should be reviewed and monitored in order to ensure the efficacy of these antibiotics for treatment.…”

Section: Introductionmentioning

confidence: 99%

Genome sequence of Vibrio sp. OULL4 isolated from shellfish

Letchumanan¹,

Tan²,

Yin³

et al. 2020

Prog Micobes Mol Biol

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The members of Vibrionaceae family are Gram-negative bacterium are ubiquitous in marine and estuarine environments. This diverse group of bacteria include many pathogenic strains that potentially cause infection to humanand aquaculture animals. Vibrio cholerae, Vibrio parahaemolyticus and Vibrio vulnificus are among the few recognized as a major, worldwide cause gastroenteritis, particularly in countries where seafood consumption is high. The control of these vibrios has been a hurdle due to the rising numbers of antibiotic resistant strains in the environments. We report the genome sequence of Vibrio sp. OULL4 isolated from shellfish. The availability of this genome sequence will facilitate the study of its antimicrobial traits, as well as add our knowledge of Vibrio sp. diversity and evolution.

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Decoding the mystery of how bacteria “talk”: Among Gram-negative microorganisms

Cited by 8 publications

References 86 publications

Unveiling the Impact of Antibiotics and Alternative Methods for Animal Husbandry: A Review

Unveiling the Impact of Antibiotics and Alternative Methods for Animal Husbandry: A Review

Incidence of antibiotic resistance in Vibrio spp

Genome sequence of Vibrio sp. OULL4 isolated from shellfish

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