Decoding the mystery of MMTV-like virus and its relationship with breast cancer metastasis

Khalid, Hafiz Fawad; Bibi, Sadia; Ali, Amjad; Fawad, Nida; Shams, Muhammad Usman; Idrees, Wafa; Waqas, Muhammad; Rafique, Shazia; khan, Abbas; Khan, Faizullah; Almajhdi, Fahad Nasser

doi:10.1016/j.jiph.2023.07.004

Cited by 4 publications

(1 citation statement)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several authors [ 25 , 100 , 102 , 108 , 123 ] failed to report any statistical association between MMTV-like virus and clinicopathological characteristics of breast cancer. Hachana et al [ 115 ] reported an inverse correlation between MMTV presence and progesterone receptor and HER2 status.…”

Section: Mmtvmentioning

confidence: 99%

The Role of Oncogenic Viruses in the Pathogenesis of Sporadic Breast Cancer: A Comprehensive Review of the Current Literature

Rossi,

Inzani,

Cesari

et al. 2024

Pathogens

View full text Add to dashboard Cite

Breast cancer is the most common malignancy in the female sex; although recent therapies have significantly changed the natural history of this cancer, it remains a significant challenge. In the past decade, evidence has been put forward that some oncogenic viruses may play a role in the development of sporadic breast cancer; however, data are scattered and mostly reported as sparse case series or small case–control studies. In this review, we organize and report current evidence regarding the role of high-risk human papillomavirus, mouse mammary tumor virus, Epstein–Barr virus, cytomegalovirus, bovine leukemia virus, human polyomavirus 2, and Merkel cell polyomavirus in the pathogenesis of breast cancer.

show abstract

Section: Mmtvmentioning

confidence: 99%

The Role of Oncogenic Viruses in the Pathogenesis of Sporadic Breast Cancer: A Comprehensive Review of the Current Literature

Rossi,

Inzani,

Cesari

et al. 2024

Pathogens

View full text Add to dashboard Cite

show abstract

Elucidating the Intricate Roles of Gut and Breast Microbiomes in Breast Cancer Metastasis to the Bone

Naik,

Godbole

2024

Cancer Reports

View full text Add to dashboard Cite

BackgroundBreast cancer is the most predominant and heterogeneous cancer in women. Moreover, breast cancer has a high prevalence to metastasize to distant organs, such as the brain, lungs, and bones. Patients with breast cancer metastasis to the bones have poor overall and relapse‐free survival. Moreover, treatment using chemotherapy and immunotherapy is ineffective in preventing or reducing cancer metastasis.Recent FindingsMicroorganisms residing in the gut and breast, termed as the resident microbiome, have a significant influence on the formation and progression of breast cancer. Recent studies have identified some microorganisms that induce breast cancer metastasis to the bone. These organisms utilize multiple mechanisms, including induction of epithelial–mesenchymal transition, steroid hormone metabolism, immune modification, bone remodeling, and secretion of microbial products that alter tumor microenvironment, and enhance propensity of breast cancer cells to metastasize. However, their involvement makes these microorganisms suitable as novel therapeutic targets. Thus, studies are underway to prevent and reduce breast cancer metastasis to distant organs, including the bone, using chemotherapeutic or immunotherapeutic drugs, along with probiotics, antibiotics or fecal microbiota transplantation.ConclusionsThe present review describes association of gut and breast microbiomes with bone metastases. We have elaborated on the mechanisms utilized by breast and gut microbiomes that induce breast cancer metastasis, especially to the bone. The review also highlights the current treatment options that may target both the microbiomes for preventing or reducing breast cancer metastases. Finally, we have specified the necessity of maintaining a diverse gut microbiome to prevent dysbiosis, which otherwise may induce breast carcinogenesis and metastasis especially to the bone. The review may facilitate more detailed investigations of the causal associations between these microbiomes and bone metastases. Moreover, the potential treatment options described in the review may promote discussions and research on the modes to improve survival of patients with breast cancer by targeting the gut and breast microbiomes.

show abstract

The association between infectious agents and breast cancer: a review of the epidemiologic evidence

Brantley,

Tamimi

2024

Breast Cancer Res Treat

View full text Add to dashboard Cite

Decoding the mystery of MMTV-like virus and its relationship with breast cancer metastasis

Cited by 4 publications

References 22 publications

The Role of Oncogenic Viruses in the Pathogenesis of Sporadic Breast Cancer: A Comprehensive Review of the Current Literature

The Role of Oncogenic Viruses in the Pathogenesis of Sporadic Breast Cancer: A Comprehensive Review of the Current Literature

Elucidating the Intricate Roles of Gut and Breast Microbiomes in Breast Cancer Metastasis to the Bone

The association between infectious agents and breast cancer: a review of the epidemiologic evidence

Contact Info

Product

Resources

About