The ontological turn in humanities and social sciences showed that science was far from being neutral because it is embedded in power structures that determine what is accepted as “truth” excluding non-Western relational ontologies as scientific, or non-objective. There are many responses to scientific enquiry and its role in modern structures of power. They range from anti-scientific to scientific fundamentalisms, and from post-structural relational and more-than-human ontologies to institutional attempts to use science to validate indigenous knowledges. However, descriptions and analysis of how subaltern grassroots communities in the Global South are decolonising science while opening epistemic emancipatory spaces where they dialogue with the state are scarce. This paper contributes to the political and academic debate about how colonial subjects are subverting and challenging scientific enquiry, along with other modern tools of epistemic control. Based on ethnographic research, this paper describes the case of Usme community, who created a decolonial understanding of science. They use scientific knowledge as a mid-level language that allows Usmekas to reconnect semantically, materially, and spiritually with nature. This reinterpretation of science aims to deconstruct the dichotomy human/nature while at the same time mobilises epistemological emancipation demands into modern institutions such as the state.