Decolonization of drug-resistant Enterobacteriaceae carriers: A scoping review of the literature

Mascolo, Annamaria; Carannante, Novella; Mauro, Gabriella di; Costanzo, Mariantonia; Licciardi, Federica; Bernardo, Mariano; Capoluongo, Nicolina; Perrella, Alessandro; Rossi, Francesco

doi:10.1016/j.jiph.2023.01.009

Cited by 5 publications

(3 citation statements)

References 28 publications

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“…Selective digestive tract decolonization (SDD) aims to reduce the gastrointestinal burden of organisms, such as resistant Enterobacterales, and prevent future infections through short courses of intravenous antibiotics or nonabsorbable oral antiinfectives followed by oral and rectal surveillance cultures to confirm eradication of these organisms. In a scoping review of the literature, Mascolo et al [37 ▪ ] found considerable heterogeneity in the existing studies exploring the effectiveness of SDD. Only 12 of the 679 studies initially identified could be included in the analysis, with only four randomized controlled trials [37 ▪ ].…”

Section: Selective Digestive Tract Decolonizationmentioning

confidence: 99%

“…In a scoping review of the literature, Mascolo et al [37 ▪ ] found considerable heterogeneity in the existing studies exploring the effectiveness of SDD. Only 12 of the 679 studies initially identified could be included in the analysis, with only four randomized controlled trials [37 ▪ ]. Existing evidence is inconclusive and does not support routine SDD.…”

Section: Selective Digestive Tract Decolonizationmentioning

confidence: 99%

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Horizontal versus vertical strategies for infection prevention: current practices and controversies

Abbas,

Stevens

2024

Current Opinion in Infectious Diseases

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Purpose of review Healthcare-associated infections (HAIs) represent a major burden on healthcare facilities. Effective infection prevention strategies are essential to prevent the spread of HAIs. These can be broadly classified as vertical and horizontal interventions. Through this review, we aim to assess the merits of these strategies. Recent findings Vertical strategies include active surveillance testing and isolation for patients infected or colonized with a particular organism. These strategies are beneficial to curb the spread of emerging pathogens and during outbreaks. However, the routine use of contact precautions for organisms such as methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus remains controversial. Horizontal interventions are larger-scale and reduce HAIs by targeting a common mode of transmission shared by multiple organisms. Among these, hand hygiene, chlorhexidine gluconate bathing of select patients and environmental decontamination are the most high-yield and must be incorporated into infection prevention programs. As antimicrobial stewardship is also an effective horizontal strategy, antimicrobial stewardship programs must operate in synergy with infection prevention programs for maximal impact. Summary Overall, horizontal interventions are considered more cost-effective and have a broader impact. Infection control programs may opt for a combination of vertical and horizontal strategies based on local epidemiology and available resources.

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Section: Selective Digestive Tract Decolonizationmentioning

confidence: 99%

Section: Selective Digestive Tract Decolonizationmentioning

confidence: 99%

Horizontal versus vertical strategies for infection prevention: current practices and controversies

Abbas,

Stevens

2024

Current Opinion in Infectious Diseases

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“…As described by ESCMID-EUCIC, a decolonizing therapy is defined as any measure leading to a reduction of detectable MDR bacteria carried at any site [ 40 ]. As a relatively new concept, strategies based on gut decolonization still have low levels of evidence, and robust recommendations cannot be provided yet [ 41 ] if not part of a registered clinical trial. Fortunately, decolonization therapies are gaining support in the field, and several strategies are currently under clinical study to carry out this elimination ( Table 1 ).…”

Section: Strategies To Decolonize the Gut From Mdr Bacteriamentioning

confidence: 99%

Insights on Current Strategies to Decolonize the Gut from Multidrug-Resistant Bacteria: Pros and Cons

et al. 2023

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In the last decades, we have witnessed a steady increase in infections caused by multidrug-resistant (MDR) bacteria. These infections are associated with higher morbidity and mortality. Several interventions should be taken to reduce the emergence and spread of MDR bacteria. The eradication of resistant pathogens colonizing specific human body sites that would likely cause further infection in other sites is one of the most conventional strategies. The objective of this narrative mini-review is to compile and discuss different strategies for the eradication of MDR bacteria from gut microbiota. Here, we analyse the prevalence of MDR bacteria in the community and the hospital and the clinical impact of gut microbiota colonisation with MDR bacteria. Then, several strategies to eliminate MDR bacteria from gut microbiota are described and include: (i) selective decontamination of the digestive tract (SDD) using a cocktail of antibiotics; (ii) the use of pre and probiotics; (iii) fecal microbiota transplantation; (iv) the use of specific phages; (v) engineered CRISPR-Cas Systems. This review intends to provide a state-of-the-art of the most relevant strategies to eradicate MDR bacteria from gut microbiota currently being investigated.

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Effect of UV-C disinfection and copper plating on healthcare-associated infections in a NICU with high ESBL infections

de la Rosa-Zamboni,

Villa-Guillén,

Bustos-Hamdan

et al. 2024

Enfermedades Infecciosas y Microbiología Clínica

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Decolonization of drug-resistant Enterobacteriaceae carriers: A scoping review of the literature

Cited by 5 publications

References 28 publications

Horizontal versus vertical strategies for infection prevention: current practices and controversies

Horizontal versus vertical strategies for infection prevention: current practices and controversies

Insights on Current Strategies to Decolonize the Gut from Multidrug-Resistant Bacteria: Pros and Cons

Effect of UV-C disinfection and copper plating on healthcare-associated infections in a NICU with high ESBL infections

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