Decompensated Non-Ischemic Cardiomyopathy Induced by Anabolic-Androgenic Steroid Abuse

Sodhi, Palwinder; Patel, Meera R; Solsi, Anup; Bellamkonda, Pallavi

doi:10.7759/cureus.11476

Cited by 3 publications

(3 citation statements)

References 13 publications

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“…Numerous case reports have described decompensated systolic heart failure as an adverse effect of excessive AAS usage. [28][29][30][31] Outpatient studies of the echocardiographic characteristics of AAS users appear to suffer from smaller sample sizes and A small observational study comparing the echocardiography characteristics of 15 AAS users (of 3-5 years in duration) to 5 controls found that the average E/A ratio was significantly lower in the AAS group. 32 Conflictingly, another small case-control study of 15 AAS users (of 2 years in duration) compared to 15 non-users found that there was no significant difference in left ventricle (LV) size, systolic function, or diastolic function.…”

Section: Anabolic Steroid Usagementioning

confidence: 99%

“…Numerous case reports have described decompensated systolic heart failure as an adverse effect of excessive AAS usage. 28–31 Outpatient studies of the echocardiographic characteristics of AAS users appear to suffer from smaller sample sizes and considerable variation in methodology, such as duration of AAS use or AAS regimen/dosage in study participants. Overall, these studies have reported mixed results regarding whether AAS usage affects cardiac mechanics in the absence of overt heart failure.…”

Section: Anabolic Steroid Usagementioning

confidence: 99%

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Cardiac Mechanics in Altered Hormonal States as a Surrogate for Understanding the Effects of Transgender Hormone Therapy

Moudgal

Peritz

Turco

et al. 2023

Cardiology in Review

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Transgender individuals are increasingly seeking the care of physicians to physically transition to their self-identified gender identity. Gender-affirming hormone therapy (GAHT) has significant endocrine effects which may have cardiovascular consequences, and cardiovascular disease in transgender individuals is a growing area of study. The effects of GAHT on cardiac mechanics have yet to be characterized, but there is existing literature regarding changes to cardiac mechanics in similar altered hormonal states. We reviewed this literature, with a focus on echocardiographic findings. We found variable results between studies of different methodologies. These include findings that supraphysiological levels of testosterone may impair cardiac mechanics, whereas estrogen-containing hormonal replacement therapy may improve diastolic echocardiographic parameters. In summary, there are alterations to echocardiographic parameters in altered endocrine states related to exogenous testosterone and estrogen, in a manner that is likely dose-dependent. Encouragingly, the studies we reviewed did not suggest that hormonal changes within physiologic ranges would detrimentally affect echocardiographic parameters of systolic and diastolic function. Future research into the cardiovascular effects of long-term GAHT is warranted to safely guide the longitudinal treatment of transgender individuals.

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Section: Anabolic Steroid Usagementioning

confidence: 99%

Section: Anabolic Steroid Usagementioning

confidence: 99%

Cardiac Mechanics in Altered Hormonal States as a Surrogate for Understanding the Effects of Transgender Hormone Therapy

Moudgal

Peritz

Turco

et al. 2023

Cardiology in Review

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“…Algunas de las células endoteliales pueden ser directamente afectadas por los EAA, lo que resultaría en vasoespasmo (30). La presencia de receptores androgénicos en la célula miocárdica intervienen en la respuesta hipertrófica de los miocitos, ocasionando hipertrofia ventricular izquierda y fibrosis miocárdica que aumenta la posibilidad de arritmias tanto supraventriculares como ventriculares, insuficiencia cardiaca grave o muerte súbita (37), (38).…”

Section: Infarto Agudo De Miocardio Y Muerte Súbitaunclassified

Efectos del consumo de esteroides anabólicos androgénicos sobre el registro electrocardiográfico del adulto joven y el control autonómico cardiaco

Rodríguez-Triviño

Rojas²,

Gómez-Coronado³

et al. 2022

Ciencia e Innovación en Salud

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El consumo de esteroides androgénicos tiene una prevalencia global de consumo del 6,4% en hombres y 1,6% en mujeres, es importante determinar los efectos del consumo de esteroides anabólicos androgénicos. Este articulo tiene como objetivo revisar cambios estructurales y moleculares miocárdicos producidos por los esteroides androgénicos anabólicos (EAA) y las complicaciones electrofisiológicas y otros trastornos que se puedan presentar por el consumo. Se realizó una revisión no sistemática de la literatura en las bases de datos MedLine, LILACS, Clinicalkey y Google Scholar. Se incluyeron 50 artículos de referencia, enfocados al objetivo de esta revisión En conclusión, el uso EAA está implicado en múltiples patologías cardiovasculares que ponen en riesgo la vida. Los cambios más frecuentes se asocian con hipertrofia ventricular cardiaca (HV), predominio simpático que desencadena hipertensión arterial entre otras alteraciones

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Insuficiência cardíaca com fração de ejeção reduzida em adultos jovens a partir do uso abusivo de hormônios esteroides anabolizantes

Luquetti Paiva,

De Campos,

Lopes

et al. 2024

rsc

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Este estudo pretende analisar os efeitos adversos cardiovasculares e os riscos de desenvolvimento de insuficiência cardíaca em adultos jovens a partir do uso abusivo de hormônios esteroides anabolizantes, com o objetivo de melhora da performance física e da aparência estética. Percebe-se que há uma congruência, entre os casos relatados, dos sintomas e das alterações morfológicas no coração em pacientes diferentes, mas que fizeram uso de anabolizantes de forma indevida. Por fim, deve-se alertar acerca do uso indevido dessas substâncias e aprimorar mecanismos de fiscalização de vendas irregulares.

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Decompensated Non-Ischemic Cardiomyopathy Induced by Anabolic-Androgenic Steroid Abuse

Cited by 3 publications

References 13 publications

Cardiac Mechanics in Altered Hormonal States as a Surrogate for Understanding the Effects of Transgender Hormone Therapy

Cardiac Mechanics in Altered Hormonal States as a Surrogate for Understanding the Effects of Transgender Hormone Therapy

Efectos del consumo de esteroides anabólicos androgénicos sobre el registro electrocardiográfico del adulto joven y el control autonómico cardiaco

Insuficiência cardíaca com fração de ejeção reduzida em adultos jovens a partir do uso abusivo de hormônios esteroides anabolizantes

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