This study revisits the trade-CO2 emissions nexus for South Africa over the period 1960–2016. Our strategy is distinctively different from previous works in the following dimensions: we employ the recently developed novel dynamic autoregressive distributed lag (ARDL) simulations framework to examine the negative and positive changes in trade openness, technological innovation, industrial growth, energy consumption, foreign direct investment, technique effect, and scale effect on CO2 emissions. Second, we use an innovative measure of trade openness developed by Squalli and Wilson (2011) to capture trade share in GDP as well as size of trade relative to world trade for South Africa. Third, we use the frequency domain causality (FDC) approach, the robust testing strategy suggested by Breitung & Candelon (2006) which enables us to explore permanent causality for medium, short and long-term relationships among variables under review. Fourth, we employ the second-generation econometric procedures accounting robustly the multiple structural breaks which have been considerably ignored in earlier studies. For South Africa, we find that: (i) higher trade openness is strikingly injurious to the environment in the long run, although it is environmentally friendly in the short run; (ii) the scale effect increases CO2 emissions whereas the technique effect improves it, validating the presence of an environmental Kuznets curve (EKC) hypothesis; (iii) energy consumption, foreign direct investment and industrial value-added deteriorate environmental quality; (iv) technological innovation contributes to lower CO2 emissions; (v) the pollution haven hypothesis (PHH) exists; (vi) InSE, InTE, InOPEN, InEC, InFDI, InTECH and InIGDP Granger-cause InCO2 in the medium, long and short run suggesting that these variables are important to influence CO2 emissions. In light of our empirical evidence, this paper suggests that the international teamwork to lessen carbon emissions is immensely critical to solve the growing trans-boundary environmental decay and other associated spillover consequences.JEL Classifications: F18, F13, Q56; O13; F1; F41