Decomposition of Aspirin in Polyethylene Glycols

Jun, H. W.; Whitworth, Clyde W.; Luzzi, L.A.

doi:10.1002/jps.2600610728

Cited by 31 publications

(8 citation statements)

References 3 publications

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“…100,[256][257][258][259][260] Though these reaction products may be ultimately hydrolyzed back to their parent compounds in the GIT, the bioavailabilities of the parent compounds could be reduced significantly. 100,[256][257][258][259][260] Though these reaction products may be ultimately hydrolyzed back to their parent compounds in the GIT, the bioavailabilities of the parent compounds could be reduced significantly.…”

Section: Reactions Between Encapsulated Compounds and Excipientsmentioning

confidence: 99%

Soft Gelatin Capsules (Softgels)

Gullapalli

2010

Journal of Pharmaceutical Sciences

111

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Section: Reactions Between Encapsulated Compounds and Excipientsmentioning

confidence: 99%

Soft Gelatin Capsules (Softgels)

Gullapalli

2010

Journal of Pharmaceutical Sciences

111

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“…Esrlier results (1) showed that degradation of aspirin in polyethylene glycols was due at least in part to transesterification ( 5 ) . The present report deals with the comparison of the stability of aspirin in formulations of unsubstituted and substituted polyethylene @ycols.The objectives were to investigate the possibility of blocking the transesterification route of degradation and to determine the effects on the stability of aspirin when this route is at least partially inhibited.…”

Section: Resultsmentioning

confidence: 99%

Stability of Aspirin in Liquid and Semisolid Bases I: Substituted and Nonsubstituted Polyethylene Glycols

Whitworth

Jun

Luzzi

1973

Journal of Pharmaceutical Sciences

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“…18) With regard to aspirin, while absorption of moisture decreased the stability and an increase in temperature promoted hydrolysis, incompatibility with excipients possibly affected its stability. Concerning the incompatibility of aspirin with the excipients used in film-coated tablets, the possibility of an increase in the free salicylic acid content when compounded with macrogol 19) and talc 20) has been reported. As seen with the 6 brands tested in this study, talc was included as an excipient in all the brands, while macrogol was included in only 3 brands.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Pharmaceutical Characteristics of Various Enteric-Coated Aspirin Tablets under Different Storage Conditions

Abe

Yanagihara

Uchino

et al. 2014

CHEMICAL & PHARMACEUTICAL BULLETIN

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The formulation characteristics of 6 brands of enteric-coated aspirin tablets under unpackaged conditions at 40°C and 60°C for 4 weeks were analyzed. Appearance, salicylic acid content, dissolution rates, and surface properties (by Raman microscopy) were evaluated to determine stability data, taking into account the clinical use of generic drugs. No change in appearance, decomposition, or dissolution rates was observed in unpackaged aspirin tablets stored at 40°C for 4 weeks. However, when stored at 60°C, tablets of 5 of the 6 brands showed whiskers on their surfaces along with an increase in salicylic acid content and a decrease in dissolution rate. Results of Raman mapping on the surface and cross sectional surface of the tablets with whiskers showed a salicylic acid peak associated with storage at 60°C for 4 weeks. However, for tablets from 1 of the 6 brands, no salicylic acid peaks were observed. For this tablet, Raman microscopy revealed 2 layers of film coating, and talc, which greatly affected the stability of the acetylsalicylic acid, was found only in the outer layer film. These results indicated that the protection of compatibility with talc is one of the important factors in enhancement of aspirin tablet stability in this tablet. We concluded that certification of the characteristics associated with stability and formulation is essential for generic drugs, which are not required to undergo stability testing under extreme storage conditions.

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Decomposition of Aspirin in Polyethylene Glycols

Cited by 31 publications

References 3 publications

Soft Gelatin Capsules (Softgels)

Soft Gelatin Capsules (Softgels)

Stability of Aspirin in Liquid and Semisolid Bases I: Substituted and Nonsubstituted Polyethylene Glycols

Evaluation of the Pharmaceutical Characteristics of Various Enteric-Coated Aspirin Tablets under Different Storage Conditions

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