Decomposition of conjugated p-tosylhydrazones in base. Partition between solvolysis and cycloaddition products

Aromás és heteroaromás vegyületek funkcionalizálása rézkatalizált átalakításban és hipervalens jodóniumsók segítségével

“…Az oldószer által stabilizált CuCF 3 (69) magas hőmérsékleten reagált az aril-jodidokkal, és jó kitermeléssel eredményezte a benzol és a piridin trifluormetilszármazékait 40 (26. ábra, A).…”

Five‐Membered Heterocycles: 1,2‐Azoles. Part 1. Pyrazoles

“…These reactive intermediates can be generated by alkaline decomposition of ethyl alkenylnitrosocarbamates [97], tosylhydrazones of a,b-unsaturated carbonyl compounds [98] or N-methoxypyrida- zinium salts [99] or from the reaction of carbonyl compounds with ethyl lithiodiazoacetate [100].…”

New “Green” Approaches to the Synthesis of Pyrazole Derivatives

“…A comparative quantitative assessment of the "greenness" of the new processes here proposed, in comparison to the classical one [10], was conducted with a rational approach of the chemical sustainability of a reaction ("Green metrics"). For this the "Environmental Assessment Tool for Organic Syntheses" software (EATOS) was used [14,15].…”

“…It is also possible to compare two or more chemical processes placing side by side their histograms and standardizing the quantities. As an example, in Figure 4 the histograms related to the environmental impact of the synthesis of compound a using both the conventional route in methanol [10], and the newly proposed microwave approaches are reported. As the order of magnitude of the environmental impact of the classic procedure is much higher, the green metrics relative to MW1 and MW2 processes are also shown in detail in Figure 5.…”