Decomposition of Exogenous 14C-Oxalate (14C-OX) to 14C-Carbon Dioxide (14CO2) In Vitro and in Animals

Hagmaier, V.; Hornig, D.; Bannwart, C.; Schmidt, Karl‐Heinz; Weber, F.; Graf, H.; Rutishauser, G

doi:10.1007/978-1-4684-8977-4_140

Cited by 6 publications

(6 citation statements)

References 7 publications

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“…Laboratory rats are widely used as models for the absorption and excretion of oxalate in humans (11); however, there is now evidence that laboratory rats are unique in that most are not colonized by oxalate-degrading bacteria (2,10,13). How this fact affects conclusions from data obtained with rats is not known because the role of oxalate-degrading bacteria in the colon has yet to be defined.…”

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confidence: 99%

Intestinal colonization of laboratory rats with Oxalobacter formigenes

Daniel

Hartman

Allison

1987

Appl Environ Microbiol

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Six strains of Oxalobacterformigenes (anaerobic oxalate-degrading bacteria) were examined for their ability to colonize the gastrointestinal tracts of adult laboratory rats. These rats did not harbor 0. formigenes. Strain OxCR6, isolated from the cecal contents of a laboratory rat that was naturally colonized by oxalate-degrading bacteria, colonized the ceca and colons of adult rats fed a diet that contained 4.5% sodium oxalate. Five days after rats were inoculated intragastrically with 109 viable cells of strain OxCR6, oxalate degradation rates in cecal and colonic contents increased by 19 and 40 times, respectively. Viable counts of strain OxCR6 from these rats averaged 108/g (dry weight) of cecal contents. Strain OxCR6 was not detected in the cecal contents of inoculated rats fed diets that contained less than 3.0% sodium oxalate. Strains of 0. formigenes isolated from the cecal contents of swine, guinea pigs, and wild rats and from human feces also colonized the ceca of laboratory rats; a ruminal strain failed to colonize the rat cecum.

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confidence: 99%

Intestinal colonization of laboratory rats with Oxalobacter formigenes

Daniel

Hartman

Allison

1987

Appl Environ Microbiol

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“…The results of several studies indicate that oxalate-degrading microbes are few or absent in laboratory rats Hagmaier et al, 1981;. Data presented here provide the first evidence that anaerobic oxalatedegrading bacteria are present in certain laboratory rats and in wild rats and the first direct cultural measurements of the concentrations of these bacteria in the cecal contents from monogastric animals.…”

Section: Discussionmentioning

confidence: 53%

“…In an effort to study the in vivo decomposition of dietary oxalate in animals, Hagmaier et al (1981) (Muller, 1950;O'Halloran, 1962) and the gastrointestinal tracts of other animals (Chandra and Shethna, 1975;Khambata and Bhat, 1953) .…”

Section: Guinea Pigs and Rabbitsmentioning

confidence: 99%

“…Attempts to demonstrate the presence of oxalate-degrading intestinal microbes in laboratory rats have been unsuccessful Hagmaier et al, 1981;). In the present study, a variety of laboratory rats and wild rats were examined for oxalate-degrading activity in their intestinal contents and for the presence of anaerobic oxalate-degrading bacteria.…”

Section: Introductionmentioning

confidence: 99%

“…Laboratory rats are widely used as models for the absorption and excretion of oxalate in man ; however, there is now evidence that laboratory rats are unique in that most are not colonized by oxalate-degrading bacteria Hagmaier et al, 1981;. How this fact affects conclusions from data obtained with rats is not known because the role of oxalate-degrading bacteria in the colon has yet to be defined.…”

Section: Introductionmentioning

confidence: 99%

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Microbial degradation of oxalate in the gastrointestinal tracts of rodents and ruminants

Daniel

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Oxalobacter formigenes gen. nov., sp. nov.: oxalate-degrading anaerobes that inhabit the gastrointestinal tract

et al. 1985

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This report describes a new group of anaerobic bacteria that degrade oxalic acid. The new genus and species, Oxalobacter formigenes, are inhabitants of the rumen and also of the large bowel of man and other animals where their actions in destruction of oxalic acid may be of considerable importance to the host. Isolates from the rumen of a sheep, the cecum of a pig, and from human feces were all similar Gram-negative, obligately anaerobic rods, but differences between isolates in cellular fatty acid composition and in serologic reaction were noted. Measurements made with type strain OxB indicated that 1 mol of protons was consumed per mol of oxalate degraded to produce approximately 1 mol of CO2 and 0.9 mol of formate. Substances that replaced oxalate as a growth substrate were not found.

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Decomposition of Exogenous 14C-Oxalate (14C-OX) to 14C-Carbon Dioxide (14CO2) In Vitro and in Animals

Cited by 6 publications

References 7 publications

Intestinal colonization of laboratory rats with Oxalobacter formigenes

Intestinal colonization of laboratory rats with Oxalobacter formigenes

Microbial degradation of oxalate in the gastrointestinal tracts of rodents and ruminants

Oxalobacter formigenes gen. nov., sp. nov.: oxalate-degrading anaerobes that inhabit the gastrointestinal tract

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