Decomposition of <scp>l</scp>-Valine under Nonthermal Dielectric Barrier Discharge Plasma

Li, Yingying; Kojtari, Arben; Friedman, Gary D.; Brooks, Ari D.; Fridman, Alexander; Ji, Hai‐Feng

doi:10.1021/jp411440k

Cited by 52 publications

(32 citation statements)

References 33 publications

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“…Previous work on decomposition of organic species focused on pollution issues [15][16], little work has done on decomposition of organic chemicals related to clinical applications [17]. As an initial attempt of a series of study of these reactions and chemical species, we demonstrate in this work the decomposition products and decomposition mechanisms of glucose, ribose, and sucrose under non-thermal DBD plasma.…”

Section: Introductionmentioning

confidence: 92%

Decomposition of sugars under non-thermal dielectric barrier discharge plasma

Li¹,

Friedman²,

Fridman³

et al. 2014

Clinical Plasma Medicine

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Section: Introductionmentioning

confidence: 92%

Decomposition of sugars under non-thermal dielectric barrier discharge plasma

Li¹,

Friedman²,

Fridman³

et al. 2014

Clinical Plasma Medicine

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“…Plasma was generated using a nanosecond-pulsed power supply with alternating polarity (FPG 20-N, FID Technology, (Burbach, Germany) and a floating electrode-dielectric barrier discharge setup (Scheme 1) identical to that used by Li et al [50]. This pulse generator provided a 1-10 ns pulse width with a rise time of 5 kV/ns between the dielectric barrier electrodes [51].…”

Section: Plasma Setup and Treatmentmentioning

confidence: 99%

Mechanism of Ampicillin Degradation by Non-Thermal Plasma Treatment with FE-DBD

Smith

Adams

2017

Plasma

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This research focused on determining the effectiveness of non-thermal atmospheric pressure plasma as an alternative to advanced oxidation processes (AOP) for antibiotic removal in solution. For this study, 20 mM (6.988 g/L) solutions of ampicillin were treated with a floating electrode dielectric barrier discharge (FE-DBD) plasma for varying treatment times. The treated solutions were analyzed primarily using mass spectrometry (MS) and nuclear magnetic resonance spectroscopy (NMR). The preliminary product formed was Ampicillin Sulfoxide, however, many more species are formed as plasma treatment time is increased. Ampicillin was completely eliminated after five minutes of air-plasma treatment. The primary mechanism of ampicillin degradation by plasma treatment is investigated in this study.

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“…However, the plasma produced at the higher pulse rate also generates greater/cytotoxic concentrations of ROS and RNS (Liu et al, 2014;Zhang et al, 2014). To date, there has been a lack of studies characterizing each plasma type and condition, which has led to a disconnect in determining how the different plasmas affect biological tissues and cellular processes (Jiang et al, 2009;Duval et al, 2013;Alekseev et al, 2014;Li et al, 2014). To further confound our understanding, isolated cells treated with plasma also tend to react much differently than treated tissues (unpublished data).…”

Section: Introductionmentioning

confidence: 99%

Chemical modification of extracellular matrix by cold atmospheric plasma-generated reactive species affects chondrogenesis and bone formation

Eisenhauer

Chernets

Song

et al. 2016

J Tissue Eng Regen Med

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The goal of this study was to investigate whether cold plasma generated by dielectric barrier discharge (DBD) modifies extracellular matrices (ECM) to influence chondrogenesis and endochondral ossification. Replacement of cartilage by bone during endochondral ossification is essential in fetal skeletal development, bone growth and fracture healing. Regulation of this process by the ECM occurs through matrix remodelling, involving a variety of cell attachment molecules and growth factors, which influence cell morphology and protein expression. The commercially available ECM, Matrigel, was treated with microsecond or nanosecond pulsed (µsp or nsp, respectively) DBD frequencies conditions at the equivalent frequencies (1 kHz) or power (~1 W). Recombinant human bone morphogenetic protein-2 was added and the mixture subcutaneously injected into mice to simulate ectopic endochondral ossification. Two weeks later, the masses were extracted and analysed by microcomputed tomography. A significant increase in bone formation was observed in Matrigel treated with µsp DBD compared with control, while a significant decrease in bone formation was observed for both nsp treatments. Histological and immunohistochemical analysis showed Matrigel treated with µsp plasma increased the number of invading cells, the amount of vascular endothelial growth factor and chondrogenesis while the opposite was true for Matrigel treated with nsp plasma. In support of the in vivo Matrigel study, 10 T1/2 cells cultured in vitro on µsp DBD-treated type I collagen showed increased expression of adhesion proteins and activation of survival pathways, which decreased with nsp plasma treatments. These results indicate DBD modification of ECM can influence cellular behaviours to accelerate or inhibit chondrogenesis and endochondral ossification.

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Decomposition of l-Valine under Nonthermal Dielectric Barrier Discharge Plasma

Cited by 52 publications

References 33 publications

Decomposition of sugars under non-thermal dielectric barrier discharge plasma

Decomposition of sugars under non-thermal dielectric barrier discharge plasma

Mechanism of Ampicillin Degradation by Non-Thermal Plasma Treatment with FE-DBD

Chemical modification of extracellular matrix by cold atmospheric plasma-generated reactive species affects chondrogenesis and bone formation

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