Abstract.One hundred thousand years of ice sheet buildup came to a rapid end ∼ 25-10 thousand years before present (ka BP), when ice sheets receded quickly and multi-proxy reconstructed global mean surface temperatures rose by ∼ 3-5 • C. It still remains unresolved whether insolation changes due to variations of earth's tilt and orbit were sufficient to terminate glacial conditions. Using a coupled three-dimensional climate-ice sheet model, we simulate the climate and Northern Hemisphere ice sheet evolution from 78 ka BP to 0 ka BP in good agreement with sea level and ice topography reconstructions. Based on this simulation and a series of deglacial sensitivity experiments with individually varying orbital parameters and prescribed CO 2 , we find that enhanced calving led to a slowdown of ice sheet growth as early as ∼ 8 ka prior to the Last Glacial Maximum (LGM). The glacial termination was then initiated by enhanced ablation due to increasing obliquity and precession, in agreement with the Milankovitch theory. However, our results also support the notion that the ∼ 100 ppmv rise of atmospheric CO 2 after ∼ 18 ka BP was a key contributor to the deglaciation. Without it, the presentday ice volume would be comparable to that of the LGM and global mean temperatures would be about 3 • C lower than today. We further demonstrate that neither orbital forcing nor rising CO 2 concentrations alone were sufficient to complete the deglaciation.