Deconvolution of evoked responses obtained at high stimulus rates

Delgado, Rafael E.; Özdamar, Özcan

doi:10.1121/1.1639327

Cited by 77 publications

(53 citation statements)

References 13 publications

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“…This is generally impossible [18]. The reason is, in simple words, that it is inherently unclear whether any peak in the response was elicited by the directly preceding stimulus, or the two-back stimulus, or possibly the three-back stimulus, or any other stimulus that came before.…”

Section: Deconvolutionmentioning

confidence: 95%

Some thoughts on the interpretation of steady-state evoked potentials

Heinrich¹

2010

Doc Ophthalmol

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Steady-state evoked potentials are popular due to their easy analysis in frequency space and the availability of methods for objective response detection. However, the interpretation of steady-state responses can be challenging due to their origin as a sequence of responses to single stimuli. In the present paper, issues of signal extinction and some characteristics of higher harmonics are illustrated based on simple model data for those readers who do not regularly hobnob with frequency-space representations of data. It is important to realize that the absence of a steady-state response does not prove the lack of neural activity. For the same underlying reasons, namely constructive and destructive superposition of individual responses, comparisons of amplitudes between experimental conditions are prone to inaccuracies. Thus, before inferring physiology from steady-state responses, one should consider an alternative explanation in terms of signal composition.

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Section: Deconvolutionmentioning

confidence: 95%

Some thoughts on the interpretation of steady-state evoked potentials

Heinrich¹

2010

Doc Ophthalmol

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“…Chirps are complex wide-band sounds crafted to stimulate a large extent of the basilar membrane simultaneously [Fobel and Dau, 2004] and therefore elicit stronger responses. Alternatively, the stimulation rate could be substantially increased by employing pseudo-random click trains, and applying decorrelation methods to extract the response to a single click [Delgado and Ozdamar, 2004;Eysholdt and Schreiner, 1982].…”

Section: Meg and Deep Sourcesmentioning

confidence: 99%

Sources of auditory brainstem responses revisited: Contribution by magnetoencephalography

Parkkonen

Fujiki

Mäkelä

2009

Human Brain Mapping

131

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Auditory brainstem responses provide diagnostic value in pathologies involving the early parts of the auditory pathway. Despite that, the neural generators underlying the various components of these responses have remained unclear. Direct electrical recordings in humans are possible only in limited time periods during surgery and from small regions of the diseased brains. The evidence of the generator sites is therefore fragmented and indirect, based strongly on lesion studies and animal models. Source modeling of EEG has been limited to grand averages across multiple subjects. Here, we employed magnetoencephalography (MEG) to shed more light on the neural origins of the auditory brainstem responses (ABR) and to test whether such deep brain structures are accessible by MEG. We show that the magnetic counterparts of the electric ABRs can be measured in 30 min and that they allow localization of some of the underlying neural sources in individual subjects. Many of the electric ABR components were present in our MEG data; however, the morphologies of the magnetic and electric responses were different, indicating that the MEG signals carry information complementary to the EEG data. The locations of the neural sources corresponding to the magnetic ABR deflections ranged from the auditory nerve to the inferior colliculus. The earliest cortical responses were detectable at the latency of 13 ms.

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“…An alternative to MLS deconvolution is Continuous Loop Averaging Deconvolution (CLAD), where basically arbitrary stimulus sequences can be used (Delgado and Özdamar, 2004). As with MLS, cyclic repetition of the sequence elicits a periodic response, and deconvolution of this response yields an estimate of the response to a single stimulus.…”

Section: Beyond Baseline Correctionmentioning

confidence: 99%

Baseline correction of overlapping event-related responses using a linear deconvolution technique

Lütkenhöner

2010

NeuroImage

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Deconvolution of evoked responses obtained at high stimulus rates

Cited by 77 publications

References 13 publications

Some thoughts on the interpretation of steady-state evoked potentials

Some thoughts on the interpretation of steady-state evoked potentials

Sources of auditory brainstem responses revisited: Contribution by magnetoencephalography

Baseline correction of overlapping event-related responses using a linear deconvolution technique

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