Deconvolution study on the glow curve structure of LiF:Mg,Ti and LiF:Mg,Cu,P thermoluminescent detectors exposed to 1 H, 4 He and 12 C ion beams

Parisi, Amilcare; Hoey, Olivier Van; Mégret, Patrice; Vanhavere, F.

doi:10.1016/j.nimb.2017.07.004

Cited by 15 publications

(4 citation statements)

References 43 publications

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“…Because of the strong influence of the glow curve signal quantification method on the dose assessment process (Parisi et al 2017a), each glow curve was individually processed in terms of background subtraction, smoothing, normalization and count integration. The subtraction of the inherent background signal was handled accordingly to the methodology described in Parisi et al (2017b). Afterwards, the glow curves were imported in the GlowView (Gieszczyk and Bilski 2017) software version 1.2.…”

Section: Discussionmentioning

confidence: 99%

“…The experimental assessment of this quantity has been carried out over the years by exposing the detectors to calibrated particles beams at ground level particle accelerators (Horowitz 1981, Benton et al 2000, Berger et al 2006, Bilski 2006, Berger and Hajek 2008, Bilski and Puchalska 2010, Bilski et al 2011, Gieszczyk et al 2013, Sądel et al 2015, Parisi et al 2017b, Parisi et al 2018a. It was concluded that the relative efficiency is not a unique function of the linear energy transfer (LET) of the incident radiation, but depends strongly also on the particle type.…”

Section: The Microdosimetric D(z) Modelmentioning

confidence: 99%

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A novel methodology to assess linear energy transfer and relative biological effectiveness in proton therapy using pairs of differently doped thermoluminescent detectors

et al. 2019

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A new methodology for assessing linear energy transfer (LET) and relative biological effectiveness (RBE) in proton therapy beams using thermoluminescent detectors is presented. The method is based on the different LET response of two different lithium fluoride thermoluminescent detectors (LiF:Mg,Ti and LiF:Mg,Cu,P) for measuring charged particles. The relative efficiency of the two detector types was predicted using the recently developed Microdosimetric d(z) Model in combination with the Monte Carlo code PHITS. Afterwards, the calculated ratio of the expected response of the two detector types was correlated with the fluence- and dose- mean values of the unrestricted proton LET. Using the obtained proton dose mean LET as input, the RBE was assessed using a phenomenological biophysical model of cell survival. The aforementioned methodology was benchmarked by exposing the detectors at different depths within the spread out Bragg peak (SOBP) of a clinical proton beam at iThemba LABS. The assessed LET values were found to be in good agreement with the results of radiation transport computer simulations performed using the Monte Carlo code GEANT4. Furthermore, the estimated RBE values were compared with the RBE values experimentally determined by performing colony survival measurements with Chinese Hamster Ovary (CHO) cells during the same experimental run. A very good agreement was found between the results of the proposed methodology and the results of the in vitro study.

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Section: Discussionmentioning

confidence: 99%

Section: The Microdosimetric D(z) Modelmentioning

confidence: 99%

A novel methodology to assess linear energy transfer and relative biological effectiveness in proton therapy using pairs of differently doped thermoluminescent detectors

et al. 2019

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“…Because of the strong influence of the glow curve signal quantification method on the dose assessment process (Parisi et al 2017a), the glow curves were individually processed in terms of inherent background subtraction, smoothing, normalization and count integration. The subtraction of the LiF:Mg,Ti inherent background signal was handled accordingly to the methodology described in Parisi et al (2017b). Afterwards, the glow curves were imported in the GlowView software version 1.3 (Gieszczyk and Bilski 2017).…”

Section: Luminescent Signal Quantificationmentioning

confidence: 99%

Modeling the radiation-induced cell death in a therapeutic proton beam using thermoluminescent detectors and radiation transport simulations

et al. 2020

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Changes in the relative biological effectiveness (RBE) of the radiation-induced cell killing of human salivary glands (HSG) were assessed along the Bragg peak of a 60 MeV clinical proton beam by means of coupling biophysical models with the results of Monte Carlo radiation transport simulations and experimental measurements with luminescent detectors. The fluence- and dose-mean unrestricted proton LET were determined along the Bragg peak using a recently developed methodology based on the combination of the response of 7LiF:Mg,Ti (MTS-7) and 7LiF:Mg,Cu,P (MCP-7) thermoluminescent detectors. The experimentally assessed LET values were compared with the results of radiation transport simulations using the Monte Carlo code PHITS, showing a good agreement. The cell survival probabilities and RBE were then calculated using the linear-quadratic model with the linear term derived using a phenomenological LET-based model (Carabe A et al 2012 Phys. Med. Biol. 57 1159) in combination with the experimentally-assessed or PHITS-simulated dose mean proton LET values. To the same aim, PHITS simulated microdosimetric spectra were used as input to the modified microdosimetric kinetic model (modified MKM, (Kase et al 2006 Radiat. Res. 166 629–38)). The RBE values calculated with the three aforementioned approaches were compared and found to be in very good agreement between each other, proving that by using dedicated pairs of thermoluminescent detectors it is possible to determine ionization density quantities of therapeutic proton beams which can be applied to predict the local value of the RBE.

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“…The disadvantage of the stimulated luminescence detectors is that their sensitivity drops rapidly for radiation with LET above 10 keV/μm. But limited information on the high LET part of the radiation can be obtained by combining different OSLDs and TLDs and by looking at the high temperature signal of the TLDs (Parisi et al 2017). The second type of passive detectors are Plastic Nuclear Track Detectors (PNTDs).…”

Section: Radiation Detectors Used In Spacementioning

confidence: 99%

Stress and Radiation Responsiveness

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Baselet²,

Hoey³

et al. 2019

Stress Challenges and Immunity in Space

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Deconvolution study on the glow curve structure of LiF:Mg,Ti and LiF:Mg,Cu,P thermoluminescent detectors exposed to 1 H, 4 He and 12 C ion beams

Cited by 15 publications

References 43 publications

A novel methodology to assess linear energy transfer and relative biological effectiveness in proton therapy using pairs of differently doped thermoluminescent detectors

A novel methodology to assess linear energy transfer and relative biological effectiveness in proton therapy using pairs of differently doped thermoluminescent detectors

Modeling the radiation-induced cell death in a therapeutic proton beam using thermoluminescent detectors and radiation transport simulations

Stress and Radiation Responsiveness

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