In this work, MoS2/BiOBr heterojunctions was prepared to applicate in degradation of Rhodamine B. It was studied comparatively with the pristine MoS2 and BiOBr. Use the detecting instrument tester such as X-ray diffraction (XRD) to confirm the formation of a composite heterostructure between MoS2 and BiOBr. MoS2/BiOBr showed excellent photocatalytic degradation efficiency toward Rhodamine B, which reaches 96.01% in 1 hour. It is 3.3 times higher than MoS2, and 1.6 times than BiOBr, respectively.