As global pressures mount to diversify supply chain strategies beyond China, the concept of “Altasia” has emerged, encompassing 14 alternative countries. This study offers a comprehensive framework describing the historical context, driving factors, and theoretical underpinnings motivating the global shift away from China. Our research model delineates the strategic pathways employed by multinational corporations to navigate the decoupling process, particularly in identifying alternative manufacturing hubs across the Altasia region. This article critically examines the multifaceted challenges and opportunities inherent in Altasia as a collective entity comprising these 14 alternative countries. Furthermore, it explores the transformative implications of this paradigm shift on the broader global supply chain ecosystem. In conclusion, we highlight the forward-looking significance of these findings, shedding light on avenues for future research endeavors in this evolving landscape.