Paget's disease is a chronic disorder of the adult skeleton characterized by focal dys-regulation of bone remodelling. The aim of this study was to demonstrate the contribution of bone scintigraphy to the diagnosis of Paget's disease. The study was observational, cross-sectional and descriptive. It included patients who underwent bone scintigraphy in the nuclear medicine department of Dakar's Idrissa Pouye General Hospital from January 2020 to June 2023, and whose results suspected or confirmed Paget's disease of the bone. We collected a total of seven (07) patients during the study period, six (06) of whom were male with an average age of 67.42 years. Two (02) reasons justified the performance of scintigraphy in these patients. These were suspicion of Paget's disease and assessment of bone extension of prostate cancer with incidental discovery of Paget's disease. Two patients (28.57% of cases) had the monostotic form and five (71.43% of cases) had the polyostotic form. All lesions found on bone scans were hyper-fixating. Three (03) patients showed bone deformities, notably deformities of the long bones, and two (02) had typical osteocondensing (hyperfixation) images of the vertebrae, giving them a "Mickey Mouse" or clover appearance. Whole-body bone scintigraphy has made an important contribution to the diagnosis and assessment of the extent of Paget's disease, with a favourable dosimetric ratio.