Decrease in Antidepressant Efficacy After Change in Generic Formulation

Generic substitution of antidepressants

“…However, proof of bioequivalence does not necessarily establish equivalence in clinical outcomes (efficacy and/or toxicity) of generic and brand‐name drugs, including psychotropics 1 , 2 . The following case describes a clinical problem that appeared to be associated with a change in generic formulations of an antidepressant in an elderly patient 3 …”

“…1,2 The following case describes a clinical problem that appeared to be associated with a change in generic formulations of an antidepressant in an elderly patient. 3…”