Decrease in CD4+ T lymphocyte proliferation responses and enhanced CD150 cell expression in health care workers non-responsive to HBV vaccine

Pati, Nirupma; Sukriti,; Hissar, Syed; Agrawal, Kamal; Rani, Rajni; Sarin, Shiv Kumar

doi:10.1016/j.vaccine.2006.10.041

Cited by 5 publications

(5 citation statements)

References 41 publications

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“…However, with triple-antigen vaccine, the percentage of nonresponse is lower than with other conventional S-containing HBV vaccine. 28,29,30 The results of the present study have an important bearing on laying down health policies in India. The study identifies the shortcomings of the current implementation policies for HBV vaccination for HCWs in India.…”

Section: Discussionmentioning

confidence: 69%

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Low levels of awareness, vaccine coverage, and the need for boosters among health care workers in tertiary care hospitals in India

Sukriti

Pati

Sethi

et al. 2008

J of Gastro and Hepatol

Self Cite

107

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Even today, 28% HCWs in India are unvaccinated and 17% are unaware of their vaccination status. This data suggests that use of hepatitis B immune globulin be mandatory in needle-pricked HCWs in India, and that implementation of awareness strategies is urgent. Since the anti-HBs titers decline in a fair proportion, there is justification for giving a booster dose of vaccine 10 years after primary vaccination to HCWs in India.

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Section: Discussionmentioning

confidence: 69%

“…Nonresponse to different types of HBV vaccines has been observed, whether the vaccine contains S‐region or PreS and S or Pre S1/Pre S2/S. However, with triple‐antigen vaccine, the percentage of nonresponse is lower than with other conventional S‐containing HBV vaccine 28,29,30 …”

Section: Discussionmentioning

confidence: 99%

Low levels of awareness, vaccine coverage, and the need for boosters among health care workers in tertiary care hospitals in India

Sukriti

Pati

Sethi

et al. 2008

J of Gastro and Hepatol

Self Cite

107

View full text Add to dashboard Cite

show abstract

“…Presentation of a narrower range of peptides may lead to diminished CD4 ϩ and CD8 ϩ T cell recognition and in turn may elicit weaker antigen-specific T cell responses. However, diminished T cell response can also be a result of T cell-mediated defects or allelic polymorphisms in genes other than HLA (25,26).…”

Section: Discussionmentioning

confidence: 99%

Human Leukocyte Antigens and Cellular Immune Responses to Anthrax Vaccine Adsorbed

et al. 2013

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. Similarly, we found that class I (HLA-A) and class II (HLA-DQA1 and HLA-DQB1) homozygosity was significantly associated with an overall decrease in LP compared with heterozygosity at those three loci. Specifically, individuals who were homozygous at these loci had significantly lower PA-specific LP than subjects heterozygous for HLA-A (median SI, 1.48 versus 2.13, P ‫؍‬ 0.005), HLA-DQA1 (median SI, 1.75 versus 2.11, P ‫؍‬ 0.007), and HLA-DQB1 (median SI, 1.48 versus 2.13, P ‫؍‬ 0.002) loci, respectively. Finally, homozygosity at an increasing number (>4) of HLA loci was significantly correlated with a reduction in LP response (P < 0.001) in a dose-dependent manner. Additional studies are needed to reproduce these findings and determine whether HLA-heterozygous individuals generate stronger cellular immune response to other virulence factors (Bacillus anthracis LF and EF) than HLA-homozygous subjects.

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“…Nevertheless, multiple investigators are developing agents that inhibit this pathway and their clinical role will likely be explored in the near future. Additional cellular targets almost assuredly exist, including CD150, expression of which has been shown to be linked to decreased CD4 + T cell proliferative responses in healthy vaccine non-responders 39 ; SOCS-1 16 , that regulates Jak/STAT signaling; and the recently described negative receptor, Tim-3 40 . Further studies focusing on these potent cell regulators in the setting of vaccine responses are ongoing, studies which might provide a novel approach in to immunization.…”

Section: Discussionmentioning

confidence: 99%

Impaired hepatitis B vaccine responses during chronic hepatitis C infection: Involvement of the PD-1 pathway in regulating CD4+ T cell responses

Moorman

Zhang

et al. 2011

Vaccine

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Vaccination for hepatitis B virus (HBV) in the setting of hepatitis C virus (HCV) infection is recommended, but responses to vaccination are blunted when compared to uninfected populations. The mechanism for this failure of immune response in HCV-infected subjects remains unknown but is thought to be a result of lymphocyte dysfunction during chronic viral infection. We have recently demonstrated that PD-1, a novel negative immunomodulator for T cell receptor (TCR) signaling, is involved in T and B lymphocyte dysregulation during chronic HCV infection. In this report, we further investigated the role of the PD-1 pathway in regulation of CD4+ T cell responses to HBV vaccination in HCV-infected individuals. In a prospective HCV infected cohort, a poor response rate to HBV vaccination as assayed by seroconversion was observed in HCV-infected subjects (53%), while a high response rate was observed in healthy or spontaneously HCV-resolved individuals (94%). CD4+ T cell responses to ex vivo stimulations of anti-CD3/CD28 antibodies or hepatitis B surface antigen (HBsAg) were found to be lower in HBV vaccine non-responders compared to those responders in HCV-infected individuals who had received a series of HBV immunizations. PD-1 expression on CD4+ T cells were detected at relatively higher levels in these HBV vaccine non-responders than those who responded, and this was inversely associated with the cell activation status. Importantly, blocking the PD-1 pathway improved T cell activation and proliferation in response to ex vivo HBsAg or anti-CD3/CD28 stimulation in HBV vaccine non-responders. These results suggest that PD-1 signaling may be involved in impairing CD4+ T cell responses to HBV vaccination in subjects with HCV infection, and raise the possibility that blocking this negative signaling pathway might improve success rates of immunization in the setting of chronic viral infection.

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Decrease in CD4+ T lymphocyte proliferation responses and enhanced CD150 cell expression in health care workers non-responsive to HBV vaccine

Cited by 5 publications

References 41 publications

Low levels of awareness, vaccine coverage, and the need for boosters among health care workers in tertiary care hospitals in India

Low levels of awareness, vaccine coverage, and the need for boosters among health care workers in tertiary care hospitals in India

Human Leukocyte Antigens and Cellular Immune Responses to Anthrax Vaccine Adsorbed

Impaired hepatitis B vaccine responses during chronic hepatitis C infection: Involvement of the PD-1 pathway in regulating CD4+ T cell responses

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