Decrease in CD8+CD45+CCR7+CD62L+ T cells in individuals vaccinated with Sinovac-CoronaVac following COVID-19 infection

Fonseca, Dâmaris C S C; Rocha, Mirtes Castelo Branco; Pereira, Lucca Adriano; Botega, Leticia P; Cutrim, Susanne C P F; Silva, Fabiano V; Batista, Flávio D; Rêgo, Adriana Sousa; Falcai, Ângela; Lima-Neto, Lidio Gonçalves; Santos, Ana Paula S A; Carvalho, R. R. de; Sousa, Eduardo Martins de

doi:10.1016/j.clim.2022.109092

Cited by 3 publications

(2 citation statements)

References 11 publications

(10 reference statements)

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“…Regarding immunity, a two-dose regimen of SV can produce B cell and CD4 T cell activation in addition to eliciting the production of notable levels of anti-RBD antibodies able to neutralize the SARS-CoV-2 variants of concern. − After SV administration, helper T lymphocyte numbers are augmented, Th2 profiles are prevalent, and increased Treg cells are also found. Three months after the second SV dose, the number of central and effector memory CD4 + and CD8 + T cells as well as serum antibody levels decreased significantly. , However, remarkable amounts of IFN-γ- and granzyme B-producing cells are detected at 28 and 90 days postvaccination …”

Section: Discussionmentioning

confidence: 99%

“…Three months after the second SV dose, the number of central and effector memory CD4 + and CD8 + T cells as well as serum antibody levels decreased significantly. 31,32 However, remarkable amounts of IFN-γ-and granzyme B-producing cells are detected at 28 and 90 days postvaccination. 33 Zhou and collaborators reported that one year after natural infection, the levels of IgG antibodies returned to the baseline and increased (3.9-fold) after immunization with inactivated vaccine and reached levels similar to those in the early stage of recovery; however, the IgA or IgM response failed to produce the same effect, suggesting that IgG is the main antibody for long-term protection.…”

Section: ■ Discussionmentioning

confidence: 99%

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Metabolic Adaptations Correlated with Antibody Response after Immunization with Inactivated SARS-CoV-2 in Brazilian Subjects

et al. 2023

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The adsorbed vaccine SARS-CoV-2 (inactivated) produced by Sinovac (SV) was the first vaccine against COVID-19 to be used in Brazil. To understand the metabolic effects of SV in Brazilian subjects, NMR-based metabolomics was used, and the immune response was studied in Brazilian subjects. Forty adults without (group − , n = 23) and with previous COVID-19 infection (group + , n = 17) were followed-up for 90 days postcompletion of the vaccine regimen. After 90 days, our results showed that subjects had increased levels of lipoproteins, lipids, and N-acetylation of glycoproteins (NAG) as well as decreased levels of amino acids, lactate, citrate, and 3-hydroxypropionate. NAG and threonine were the highest correlated metabolites with N and S proteins, and neutralizing Ab levels. This study sheds light on the immunometabolism associated with the use of SV in Brazilian subjects from Rio de Janeiro and identifies potential metabolic markers associated with the immune status.

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Section: Discussionmentioning

confidence: 99%

Section: ■ Discussionmentioning

confidence: 99%

Metabolic Adaptations Correlated with Antibody Response after Immunization with Inactivated SARS-CoV-2 in Brazilian Subjects

et al. 2023

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Chemokine receptors in COVID-19 infection

Gutierrez-Chavez,

Aperrigue-Lira,

Ortiz-Saavedra

et al. 2024

International Review of Cell and Molecular Biology

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Weighted gene co-expression network analysis revealed T cell differentiation associated with the age-related phenotypes in COVID-19 patients

Yao

Chen

et al. 2023

BMC Med Genomics

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The risk of severe condition caused by Corona Virus Disease 2019 (COVID-19) increases with age. However, the underlying mechanisms have not been clearly understood. The dataset GSE157103 was used to perform weighted gene co-expression network analysis on 100 COVID-19 patients in our analysis. Through weighted gene co-expression network analysis, we identified a key module which was significantly related with age. This age-related module could predict Intensive Care Unit status and mechanical-ventilation usage, and enriched with positive regulation of T cell receptor signaling pathway biological progress. Moreover, 10 hub genes were identified as crucial gene of the age-related module. Protein–protein interaction network and transcription factors-gene interactions were established. Lastly, independent data sets and RT-qPCR were used to validate the key module and hub genes. Our conclusion revealed that key genes were associated with the age-related phenotypes in COVID-19 patients, and it would be beneficial for clinical doctors to develop reasonable therapeutic strategies in elderly COVID-19 patients.

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Decrease in CD8+CD45+CCR7+CD62L+ T cells in individuals vaccinated with Sinovac-CoronaVac following COVID-19 infection

Cited by 3 publications

References 11 publications

Metabolic Adaptations Correlated with Antibody Response after Immunization with Inactivated SARS-CoV-2 in Brazilian Subjects

Metabolic Adaptations Correlated with Antibody Response after Immunization with Inactivated SARS-CoV-2 in Brazilian Subjects

Chemokine receptors in COVID-19 infection

Weighted gene co-expression network analysis revealed T cell differentiation associated with the age-related phenotypes in COVID-19 patients

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