Decrease in leptin mediates rat bone metabolism impairments during high-fat diet-induced catch-up growth by modulating the OPG/RANKL balance

Liu, Xiaoling; Liang, Yao; Xia, Ning; Liu, Weiming; Yang, Qiong; Wang, Caimei

doi:10.1007/s13205-021-02658-2

Cited by 7 publications

(4 citation statements)

References 41 publications

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“…On the other hand, future studies should investigate whether prenatal exposure to higher FBs doses results in the impairment of insulin receptors and lower concentrations of OC and leptin in weaned males. It is well-known that leptin reduces RANKL [66]. Thus, weaned male rats showed the decreased concentration of leptin and enhanced RANKL concentration.…”

Section: Discussionmentioning

confidence: 93%

Prenatal Fumonisin Exposure Impairs Bone Development via Disturbances in the OC/Leptin and RANKL/RANK/OPG Systems in Weaned Rat Offspring

Tomaszewska

Rudyk

Muszyński

et al. 2023

IJMS

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The goal of the current study was to examine the effects of prenatal exposure to fumonisins (FBs) on bone properties and metabolism in weaned rat offspring divided into groups intoxicated with FBs at either 0 (the 0 FB group), 60 (the 60 FB group), or 90 mg/kg b.w. 0 (the 90 FB group). Female and male offspring exposed to FBs at a dose of 60 mg/kg b.w. had heavier femora. Mechanical bone parameters changed in a sex and FBs dose-dependent manner. Growth hormone and osteoprotegerin decreased in both sexes, regardless of FBs dose. In males osteocalcin decreased, while receptor activator for nuclear factor kappa-Β ligand increased regardless of FBs dose; while in females changes were dose dependent. Leptin decreased in both male FBs-intoxicated groups, bone alkaline phosphatase decreased only in the 60 FB group. Matrix metalloproteinase-8 protein expression increased in both female FBs-intoxicated groups and decreased in male 90 FB group. Osteoprotegerin and tissue inhibitor of metalloproteinases 2 protein expression decreased in males, regardless of FBs dose, while nuclear factor kappa-Β ligand expression increased only in the 90 FB group. The disturbances in bone metabolic processes seemed to result from imbalances in the RANKL/RANK/OPG and the OC/leptin systems.

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Section: Discussionmentioning

confidence: 93%

Prenatal Fumonisin Exposure Impairs Bone Development via Disturbances in the OC/Leptin and RANKL/RANK/OPG Systems in Weaned Rat Offspring

Tomaszewska

Rudyk

Muszyński

et al. 2023

IJMS

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“…Metabolic factors related to obesity involving leptin and estrogens have protective effects on BMD [ 33 ]. Leptin, produced by adipocytes, may act peripherally by increasing osteoprotegerin levels leading to binding of RANKL, resulting in inhibition of osteoclastogenesis [ 34 , 35 ]. Additionally, estradiol hormone therapy resulted in significant increase of BMD [ 36 ] and this may be because it can attenuate the subclinical inflammatory bone-microenvironment that is accompanied by an increase in oxidative stress and the generation of advanced glycation end products [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

The relationship between central obesity and bone mineral density: a Mendelian randomization study

Jing

Zhang

et al. 2022

Diabetol Metab Syndr

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Background The relationship between obesity and osteoporosis is an important public health issue. The goal of this study was to investigate whether and to what extent central obesity traits affect bone mineral density (BMD). Methods We conducted a two-sample Mendelian randomization analysis. Genomewide significant single nucleotide polymorphisms associated with waist circumference, hip circumference, waist-to-hip ratio, waist circumference adjusted by body mass index (WCadjBMI), hip circumference adjusted by BMI (HCadjBMI) and waist-to-hip ratio adjusted by BMI (WHRadjBMI) were obtained from a large-scale database containing 224,459 samples. The BMD summary dataset was obtained from a UK Biobank database including 265,627 participants. Results The results provided strong evidence that the HCadjBMI trait was causally and negatively associated with BMD (β: − 0.135, 95% CI − 0.216 to − 0.054; P = 0.001), while the WHR trait was causally and positively associated with BMD (β: 0.194, 95% CI 0.062 to 0.325, P = 0.004). No significant effects were observed for other traits on BMD. Conclusions This study indicates variations in the abilities of different central obesity traits to influence BMD. These results should be considered in further studies and public health measures on obesity and osteoporosis prevention strategies.

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“… 141 Reduction of leptin resulted in rat bone metabolism disorder during high-fat-diet-induced catch-up growth, via balancing the OPG/RANKL signaling pathway. 142 Furthermore, leptin enhances BMP9-induced osteogenic differentiation of MSCs by activating JAK/STAT signaling. 143 Additionally, leptin reduces cementoblast mineralization and survival via ERK1/2 activation in vitro.…”

Section: The Hypothalamus Processes Interoceptive Signals To Maintain...mentioning

confidence: 99%

Interoceptive regulation of skeletal tissue homeostasis and repair

Xiao,

Han,

Wang

et al. 2023

Bone Res

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Recent studies have determined that the nervous system can sense and respond to signals from skeletal tissue, a process known as skeletal interoception, which is crucial for maintaining bone homeostasis. The hypothalamus, located in the central nervous system (CNS), plays a key role in processing interoceptive signals and regulating bone homeostasis through the autonomic nervous system, neuropeptide release, and neuroendocrine mechanisms. These mechanisms control the differentiation of mesenchymal stem cells into osteoblasts (OBs), the activation of osteoclasts (OCs), and the functional activities of bone cells. Sensory nerves extensively innervate skeletal tissues, facilitating the transmission of interoceptive signals to the CNS. This review provides a comprehensive overview of current research on the generation and coordination of skeletal interoceptive signals by the CNS to maintain bone homeostasis and their potential role in pathological conditions. The findings expand our understanding of intersystem communication in bone biology and may have implications for developing novel therapeutic strategies for bone diseases.

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Decrease in leptin mediates rat bone metabolism impairments during high-fat diet-induced catch-up growth by modulating the OPG/RANKL balance

Cited by 7 publications

References 41 publications

Prenatal Fumonisin Exposure Impairs Bone Development via Disturbances in the OC/Leptin and RANKL/RANK/OPG Systems in Weaned Rat Offspring

Prenatal Fumonisin Exposure Impairs Bone Development via Disturbances in the OC/Leptin and RANKL/RANK/OPG Systems in Weaned Rat Offspring

The relationship between central obesity and bone mineral density: a Mendelian randomization study

Interoceptive regulation of skeletal tissue homeostasis and repair

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