Decrease in microvesicle-associated tissue factor activity in morbidly obese patients after bariatric surgery

Abstract

We could demonstrate a significant decrease in MV-TF activity after weight loss in morbidly obese patients. Decreased MV-TF activity might contribute to an improved coagulation profile in these patients after weight loss.

Risk of venous thrombosis in persons with increased body mass index and interactions with other genetic and acquired risk factors

“…Recent evidence points towards microparticles as potential promoters of a hypercoagulable state in both obese individuals and FV Leiden carriers . Interestingly, microparticle activity is reduced in obese individuals after weight loss . Therefore, our study, combined with other studies that have investigated the etiologic aspects of hypercoagulability in obesity , suggests that weight loss, especially in obese individuals with FV Leiden, could contribute to a decrease in VT risk.…”

“…Interestingly, microparticle activity is reduced in obese individuals after weight loss [14]. Therefore, our study, combined with other studies that have investigated the etiologic aspects of hypercoagulability in obesity [1,4,6,[12][13][14], suggests that weight loss, especially in obese individuals with FV Leiden, could contribute to a decrease in VT risk. A limitation of our study is that we cannot directly obtain absolute risk estimates from case-control data, which hampers clinical decision-making with respect to thromboprophylaxis.…”

The Evaluation of Cardiovascular Risk Parameters Using Multiplex Immunoassay in Women with Primary Hyperlipiemia and Obese HyperlipidemicWomen

“…Various cells release tissue factor circulation upon cell activation and apoptosis. 35 In our study, no significant statistical difference was found in serum tissue factor levels of primary hyperlipidemic, obese hyperlipidemic and control cases. When we reviewed the literature, we reached different conclusions from our findings.…”

“…Ay et al found that their serum tissue factor levels were significantly higher in 74 morbidly obese patients. 35 They also reported that serum tissue factor levels of morbid obese patients decreased after they lost weight in the same study. It is also stated that coagulation profiles of these patients improve after weight loss.…”

“…Tissue factor is an important in vivo initiator in blood coagulation stage. 35,36 Tissue factor, which is active in circulation, has been detected in negatively charged membrane vesicles called microvesicles. Various cells release tissue factor circulation upon cell activation and apoptosis.…”