Decrease in Mortality after the Implementation of a Hospital Model to Improve Performance in Sepsis Care: Princess Sepsis Code

Abstract

Sepsis is a time-dependent disease whose prognosis is influenced by early diagnosis and therapeutic measures. Mortality from sepsis remains high, and for this reason, the guidelines of the Surviving Sepsis Campaign recommend establishing specific care programs aimed at patients with sepsis. We present the results of the application of a hospital model to improve performance in sepsis care, called Princess Sepsis Code, with the aim of reducing mortality. A retrospective study was conducted using clinical, epidemiological, and outcome variables in patients diagnosed with sepsis from 2015 to 2022. A total of 2676 patients were included, 32% of whom required admission to the intensive care unit, with the most frequent focus of the sepsis being abdominal. Mortality in 2015, at the beginning of the sepsis code program, was 24%, with a declining rate noted over the study period, with mortality reaching 17% in 2022. In the multivariate analysis, age > 70 years, respiratory rate > 22 rpm, deterioration in the level of consciousness, serum lactate > 2 mmol/L, creatinine > 1.6 mg/dL, and the focus of the sepsis were identified as variables independently related to mortality. The implementation of the Princess Sepsis Code care model reduces the mortality of patients exhibiting sepsis and septic shock.

Lactate Levels and Clearance: Key Predictors of Prognosis for COVID-19 and Non-COVID-19 Septic Shock Patients in the Emergency Department

“…The critical role of lactate in prognosticating outcomes in septic shock, as demonstrated in our study, resonates with the findings of Méndez et al (2024), who underscored the prognostic significance of biomarkers like lactate in sepsis management across various clinical settings [2]. Our findings extend this understanding by elucidating the specific impact of COVID-19 on lactate dynamics, thereby enriching the existing literature on the biomarkers of sepsis.…”

“…Sepsis is a life-threatening syndrome that leads to hemodynamic instability, and is defined as a life-threatening organ dysfunction secondary to the host’s dysregulated response to infection [ 1 , 2 ]. Considering its high incidence in the population and its high impact on hospital mortality, sepsis represents a significant threat.…”