Decrease in pregnancy rate after endometrial scratch in women undergoing a first or second<i>in vitro</i>fertilization. A multicenter randomized controlled trial

Frantz, Sandrine; Parinaud, Jean; Krêt, Marion; Rocher-Escriva, Gaelle; Papaxanthos-Roche, Aline; Creux, H.; Chansel‐Debordeaux, Lucie; Bénard, Antoine; Hocké, C.

doi:10.1093/humrep/dey334

Cited by 34 publications

(38 citation statements)

References 30 publications

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“…However, subgroup analyses indicate an increase in the clinical pregnancy rate in women with three or more previous implantation failures. These results are consistent with previous research that reported that women with RIF in particular may benefit from endometrial scratching (5,(8)(9)(10)12), while no significant improvement could be demonstrated in unselected subfertile women (11,13,15).…”

Section: Discussionsupporting

confidence: 92%

“…This led to the first published study on 134 patients, which showed a twofold increase in live birth rate (48.9% vs 22.5 %) (5). Subsequently, a number of studies have indicated a potential clinical value of this intervention (4,6,7), particularly in repeated implantation failure (RIF) patients (5,(8)(9)(10), while others failed to detect a benefit in patients, mainly in those undergoing their first or second IVF attempt (11)(12)(13)(14)(15). In contrast, a randomized controlled trial (RCT) showed that endometrial scratching carried out on the day of oocyte pickup resulted in a reduction of approximately two-thirds in the implantation rate in comparison with the control group (16).…”

mentioning

confidence: 99%

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Therapeutic endometrial scratching and implantation after in vitro fertilization: a multicenter randomized controlled trial

Olesen

Hauge

Ohrt

et al. 2019

Fertility and Sterility

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Objective: To study whether endometrial scratching in the luteal phase before ovarian stimulation increases clinical pregnancy rates in women with one or more previous implantation failures. Design: A nonblinded multicenter randomized clinical trial. Setting: Fertility clinics. Patient(s): Three hundred four eligible patients scheduled for IVF/intracytoplasmic sperm injection were randomized. The intervention group (n ¼ 151) underwent endometrial scratching in the luteal phase before controlled ovarian stimulation, while no intervention was performed in the control group (n ¼ 153). Intervention(s): Endometrial scratching with a Pipelle de Cornier catheter in the luteal phase before ovarian stimulation. Main Outcome Measure(s): Clinical pregnancy rate and prenatal and birth data. Result(s): There was no overall significant improvement in clinical pregnancy rates between the control and intervention groups (38.5% vs. 44.4%; relative risk ¼ 1.15; confidence interval [0.86-1.55]). However, subgroup analyses revealed that women with three or more previous implantation failures had a significant increase in clinical pregnancy rate (31.1% vs. 53.6%; relative risk ¼ 1.72; confidence interval [1.05-2.83]) after scratching. No difference was seen as regards prenatal and birth data between the two groups. Conclusion(s): Endometrial scratching in the luteal phase before ovarian stimulation significantly enhances the clinical pregnancy rate in women with three or more prior implantation failures. This result seems to corroborate previous reports, which found that particularly women with repeated implantation failure seem to gain a positive effect from endometrial scratching. Importantly, there were no significant differences in prenatal data and birth data between the groups.

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Section: Discussionsupporting

confidence: 92%

mentioning

confidence: 99%

Therapeutic endometrial scratching and implantation after in vitro fertilization: a multicenter randomized controlled trial

Olesen

Hauge

Ohrt

et al. 2019

Fertility and Sterility

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“…Finally, 17 references 12,[20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] comprising 3016 patients, 1498 in the EI group, and 1518 in the control group were included in our meta-analysis.…”

Section: Study Selectionmentioning

confidence: 99%

“…All authors were contacted by email to provide additional information, only three responded. 12,30,33 Table 1 summarizes the characteristics of the included RCTs.…”

Section: Study Selectionmentioning

confidence: 99%

“…12,27,29,30,35 Due to high risk of bias in the randomization process and allocation according to the clinical case record number, the study published by Matsumato et al was excluded from our analysis. 36 Eleven studies included patients with at least one previous failed cycle, 12,[20][21][22]26,27,[29][30][31]33,35 four studies included patients with at least two previous failed cycles, [23][24][25]34 and the remaining two studies 28,32 included patients with at least three previous failed IVF cycles ( Table 1). Three studies, in addition to presenting the data for patients with at least one previous failed cycle, provided further data for patients with at least two previous failed cycles.…”

Section: Study Characteristicsmentioning

confidence: 99%

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The impact of endometrial injury on reproductive outcomes: results of an updated meta‐analysis

Nahshon

Sagi‐Dain

Dirnfeld

2020

Reprod Medicine & Biology

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Implantation success following in vitro fertilization (IVF) relays on several factors, including embryonic quality and endometrial receptivity. 1,2 Repeated implantation failure (RIF) after IVF and embryo transfer (ET) is a frequent problem many patients struggle with. Two definitions of RIF are acceptable in the academic and clinical fields. The recent definition refers to RIF as failure to achieve a pregnancy after transferring at least four good-quality embryos in a minimum of three cycles in a woman under the age of 40 years. 3 This annotation differs from the former definition that described RIF as failure to achieve pregnancy following two to six IVF cycles, with at least ten good-quality embryos transferred. 4 Endometrial injury (EI) was first described as a beneficial procedure for women with RIF during IVF treatments by Barash et al. in 2003. 5 In this procedure, also known as endometrial scratching, the

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Endometrial injury in women undergoing in vitro fertilisation (IVF)

Lensen

Armstrong

Gibreel

et al. 2021

Cochrane Database of Systematic Reviews

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Decrease in pregnancy rate after endometrial scratch in women undergoing a first or secondin vitrofertilization. A multicenter randomized controlled trial

Cited by 34 publications

References 30 publications

Therapeutic endometrial scratching and implantation after in vitro fertilization: a multicenter randomized controlled trial

Therapeutic endometrial scratching and implantation after in vitro fertilization: a multicenter randomized controlled trial

The impact of endometrial injury on reproductive outcomes: results of an updated meta‐analysis

Endometrial injury in women undergoing in vitro fertilisation (IVF)

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