Decrease in Serum Protein Carbonyl Groups Concentration and Maintained Hyperhomocysteinemia in Patients Undergoing Bariatric Surgery

Abstract

This study demonstrates that bariatric surgery has protective effect on oxidative protein damage and improves several laboratory parameters including serum lipid concentration and insulin resistance. However, bariatric surgery does not cause a decrease in serum homocysteine concentration, a risk factor for the development of cardiovascular diseases. Collectively, the results presented in this paper suggest that serum homocysteine concentration is not directly associated with oxidative stress in obese patients after bariatric surgery.

Obesity, bariatric surgery and oxidative stress

“…This explains the high CP levels in the pre-surgical obese group assessed in the current study, as well as the reduced protein damages after the surgery, since the patients had already shown weight loss by then. These results corroborate a similar study conducted by Sledzinski et al, 32 who found CP levels in obese individuals approximately to be 50% higher than those of the non-obese group, and CP levels to be similar to those of the control group six months after gastric surgery.…”

Glutathione s-transferase p in glucose homeostasis in mice.

“…Consistent with the view that ROS-mediated injury can be attributed in part to lipid-derived aldehydes, almost 7% of AFABP in adipose tissue was covalently modified by 4-HNE in obese insulin-resistant C57Bl/6J mice, resulting in a decreased binding affinity for fatty acids [30]. Increased plasma protein carbonyls, as a biomarker of systemic oxidative stress, was positively correlated with IR in obese patients [31] and was significantly decreased following treatment [32,33]. As a result of these (and many more) findings, there has been a surge in interest in evaluating how aldehyde metabolism and protein carbonylation may serve as a mechanistic link between oxidative stress and IR.…”

Changes in Oxidative Stress and Insulin Resistance in Morbidly Obese Patients After Bariatric Surgery

“…NADPH oxidase inhibition reduces oxidative stress in white adipose tissue, and this improves insulin sensitivity and the metabolic profile. Some studies have found that 6 months after bariatric surgery, there is a reduction in the oxidative stress of the patients [27,28]. Our results seem to indicate that 90 days after surgery, these mechanisms have a secondary role in the resolution of insulin resistance in duodenal-jejunal bypass patients, because although GSHTf and GSH-Rd activity increased and LPO levels decreased significantly, showing an improvement in oxidative stress, the total antioxidant capacity and the activity of catalase or superoxide dismutase did not vary significantly during the study.…”