Decrease in Serum Urate Level Is Associated With Loss of Visceral Fat in Male Gout Patients

Ran, Zijing; Xue, Xiaomei; Han, Lin; Terkeltaub, Robert; Merriman, Tony R.; Zhao, Ting; He, Yuwei; Wang, Can; Li, Xinde; Liu, Zhen; Cui, Lingling; Li, Hailong; Ji, Aichang; Hu, Shuhui; Lü, Jie; Li, Changgui

doi:10.3389/fendo.2021.724822

Cited by 8 publications

(11 citation statements)

References 50 publications

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“…Several epidemiological studies have suggested that obesity plays an important role in HUA [ 10 , 27 ]; however, the function of body fat distribution in UA metabolism remains unclear. Consistent with previous research [ 28 , 29 ], we demonstrated that visceral fat is strongly related to many health conditions, including HUA, diabetes, hypertension, gout, and CKD. According to a study by Huang et al [ 11 ], the visceral adipose increase was strongly linked to HUA in Chinese people, but the research is only limited to middle-aged and elderly people.…”

Section: Discussionsupporting

confidence: 92%

Association of Visceral Fat Area and Hyperuricemia in Non-Obese US Adults: A Cross-Sectional Study

Gao

Zhong

et al. 2022

Nutrients

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This study aimed to investigate the relationship between visceral fat area (VFA) and hyperuricemia (HUA) among non-obese adults. We extracted data from 6224 US adults aged 20–59 years from the National Health and Nutrition Examination Survey (NHANES) from 2011–2018. The VFA was divided into four quartiles (Q1–Q4). We used multivariable logistic regression models to control for known confounders. A generalized additive model (GAM) and restricted cubic spines were used to examine the association between VFA and HUA stratified by sex, and a two-piecewise linear regression model was used to calculate the threshold effect among males. The results revealed that the prevalence of HUA was 11.8% (men 15.8%, women 7.2%). In the fully adjusted model, there was a positive association between VFA and HUA [as a quartile variable, Q4 vs. Q1, odds ratio (OR): 3.77 and 95% confidence interval (CI): (2.47~5.75), p < 0.001, p for trend < 0.001; as a continuous variable, per 10 cm2 increment, OR (95%CI):1.10(1.07,1.14), p < 0.001]. Besides, this positive association remained significantly stratified by sex. Interestingly, we observed a nonlinear dose-response relationship between VFA and HUA in males (inflection point: 107.46 cm2). In conclusion, our study confirmed a significant positive relationship between VFA and HUA among non-obese adults and remained statistically significant when stratified by sex.

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Section: Discussionsupporting

confidence: 92%

Association of Visceral Fat Area and Hyperuricemia in Non-Obese US Adults: A Cross-Sectional Study

Gao

Zhong

et al. 2022

Nutrients

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“…Furthermore, visceral fat was more closely associated with high SUA levels compared to subcutaneous fat (15). Reduced visceral fat area was associated with a decrease in SUA level (16). Based on such evidence, visceral fat is suggested to be a significant risk marker for SUA.…”

Section: Introductionmentioning

confidence: 90%

Perirenal Fat Volume Is Positively Associated With Serum Uric Acid Levels in Chinese Adults

Jiang

Liu

et al. 2022

Front. Endocrinol.

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BackgroundVisceral fat has been considered an important risk factor of elevated serum uric acid (SUA). Perirenal fat is a unique visceral fat around the kidneys that has special morphological and physiological features while its relationship with SUA remains incompletely elucidated. This study aimed to assess the association between perirenal fat volume (PrFV) and SUA.MethodsA cross-sectional study was conducted in 102 subjects aged ≥ 18 years old recruited from Nanjing,China. The clinical characteristics including age, sex, drinking behavior, history of hypertension, body mass index, waist circumference, total cholesterol, fast plasma glucose, urea, serum creatinine, C-reactive protein, and SUA were recorded. PrFV was measured by ultrasonography. Multivariate linear models and the restricted cubic spline were used to investigate the association between PrFV and SUA.ResultsThe median age of this study population was 52.5 (42.0-60.0) years and 56.9% were female. The median value of SUA was 5.73 mg/dL (4.58-6.80 mg/dL). The subjects were divided by PrFV tertiles and we found that the subjects in the highest PrFV tertile had a higher level of SUA compared to those in the lowest tertile (β=1.86, 95%CI 1.23–2.48, P for trend <0.001).The positive association also remained after adjustment for potential covariates (tertile3 versus tertile1: β=0.99, 95%CI 0.35-1.63, P for trend =0.005). There was an increase of approximately 0.53 mg/dL in SUA per 1-fold increase in PrFV (β=0.53, 95%CI 0.02-1.04, P for nonlinearity = 0.637).ConclusionOur results confirmed a positive independent relationship between PrFV and SUA in Chinese adults. This study suggested that perirenal fat might constitute a potential risk factor for elevated serum uric acid levels.

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“…Previous studies showed that elevated serum uric facilitates insulin resistance-mediated accumulation of visceral fat [ 38 , 39 ]. Whereas low SUA levels with anti-hyperuricemia promote overall metabolic conditions and loss of VAT [ 20 , 40 ]. The role of increased SUA appears to be greater when considering Adipo-IR as a promoter of VAT accumulation [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

“…Visceral fat has been reported as the most influential factor in hyperuricemia [ 19 ]. Moreover, the decrease in SUA level is positively associated with reduced visceral fat area in gout patients [ 20 ]. Various epidemiological and clinical studies have reported an association between hyperuricemia and Nonalcoholic fatty liver disease (NAFLD) [ 21 – 23 ].…”

Section: Introductionmentioning

confidence: 99%

Correlation between serum uric acid and body fat distribution in patients with MAFLD

Tao,

Liu,

Chen

et al. 2023

BMC Endocr Disord

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Background Metabolic dysfunction associated with fatty liver disease (MAFLD) is often correlated with obesity and hyperuricemia. The present study aimed to determine the association between serum uric acid (SUA) and central fat distribution in patients with MAFLD. Methods A total of 485 patients were classified into the following groups: (1) controls without MAFLD and hyperuricemia (HUA), (2) MAFLD with normal SUA, and (3) MAFLD with HUA. DUALSCAN HDS-2000 was used to measure visceral fat (VAT) and subcutaneous fat (SAT). Dual-energy X-ray absorptiometry (DEXA) was used to measure body fat distribution. Results MAFLD patients with HUA had remarkably higher BMI, fasting insulin, OGIRT AUC, ALT, AST, TG, VAT, SAT, Adipo-IR, trunk fat mass, android fat, and total body fat than MAFLD patients with normal SUA (all p < 0.05). The increase in VAT, SAT, CAP, Adipo-IR, upper limbs fat mass, trunk fat mass, and android fat, as well as the percentage of MAFLD, were significantly correlated with the increase in SUA. The percentage of MAFLD patients with HUA increased significantly with increasing VAT or SAT, as determined by the Cochran–Armitage trend test (all p < 0.05). Furthermore, VAT (OR = 1.01 CI: 1.00, 1.03; p < 0.05) and adipo-IR (OR = 1.09 CI: 1.00, 1.19; p < 0.05) were associated with circling SUA in MAFLD after adjusting for sex, age, TG, TC, HOMA-IR, and BMI. Conclusion Abdominal fat promotes the co-existence of HUA and MAFLD, while weight loss, especially, decreasing VAT, is of great importance to decrease SUA levels and manage MAFLD.

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Decrease in Serum Urate Level Is Associated With Loss of Visceral Fat in Male Gout Patients

Cited by 8 publications

References 50 publications

Association of Visceral Fat Area and Hyperuricemia in Non-Obese US Adults: A Cross-Sectional Study

Association of Visceral Fat Area and Hyperuricemia in Non-Obese US Adults: A Cross-Sectional Study

Perirenal Fat Volume Is Positively Associated With Serum Uric Acid Levels in Chinese Adults

Correlation between serum uric acid and body fat distribution in patients with MAFLD

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