Decrease in the nucleo-cytoplasmic volume ratio of rabbit spinal ganglion neurons with age

Ledda, M.; Barni, Luisa; Altieri, L.; Pannese, Ennio

doi:10.1016/s0304-3940(00)01116-2

Cited by 12 publications

(8 citation statements)

References 10 publications

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“…Generally speaking, the fraction of cell body occupied by the nucleus decreases during post-natal development [Ribeiro et al, 2004;Gagliardo et al, 2005;Ribeiro, 2006], whereas the cell body itself increases. The same pattern was also found in the present study, that is a 0.4-to 0.5-fold decrease in the nucleus-cell body ratio from young to adult dogs, cats and horses, as well as in rabbit spinal ganglion neurons with ageing [Ledda et al, 2000].…”

Section: Morphometrysupporting

confidence: 91%

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Macro- and Microstructure of the Superior Cervical Ganglion in Dogs, Cats and Horses during Maturation

Fioretto

Abreu

Castro

et al. 2007

Cells Tissues Organs

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The superior cervical ganglion (SCG) provides sympathetic input to the head and neck, its relation with mandible, submandibular glands, eyes (second and third order control) and pineal gland being demonstrated in laboratory animals. In addition, the SCG’s role in some neuropathies can be clearly seen in Horner’s syndrome. In spite of several studies published involving rats and mice, there is little morphological descriptive and comparative data of SCG from large mammals. Thus, we investigated the SCG’s macro- and microstructural organization in medium (dogs and cats) and large animals (horses) during a very specific period of the post-natal development, namely maturation (from young to adults). The SCG of dogs, cats and horses were spindle shaped and located deeply into the bifurcation of the common carotid artery, close to the distal vagus ganglion and more related to the internal carotid artery in dogs and horses, and to the occipital artery in cats. As to macromorphometrical data, that is ganglion length, there was a 23.6% increase from young to adult dogs, a 1.8% increase from young to adult cats and finally a 34% increase from young to adult horses. Histologically, the SCG’s microstructure was quite similar between young and adult animals and among the 3 species. The SCG was divided into distinct compartments (ganglion units) by capsular septa of connective tissue. Inside each ganglion unit the most prominent cellular elements were ganglion neurons, glial cells and small intensely fluorescent cells, comprising the ganglion’s morphological triad. Given this morphological arrangement, that is a summation of all ganglion units, SCG from dogs, cats and horses are better characterized as a ganglion complex rather than following the classical ganglion concept. During maturation (from young to adults) there was a 32.7% increase in the SCG’s connective capsule in dogs, a 25.8% increase in cats and a 33.2% increase in horses. There was an age-related increase in the neuronal profile size in the SCG from young to adult animals, that is a 1.6-fold, 1.9-fold and 1.6-fold increase in dogs, cats and horses, respectively. On the other hand, there was an age-related decrease in the nuclear profile size of SCG neurons from young to adult animals (0.9-fold, 0.7-fold and 0.8-fold in dogs, cats and horses, respectively). Ganglion connective capsule is composed of 2 or 3 layers of collagen fibres in juxtaposition and, as observed in light microscopy and independently of the animal’s age, ganglion neurons were organised in ganglionic units containing the same morphological triad seen in light microscopy.

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Section: Morphometrysupporting

confidence: 91%

“…This ratio decreases when the area occupied by cytoplasm increases compared to the nuclear area and that seems to be the case during post-natal development [Ledda et al, 2000;Gagliardo et al, 2005].…”

Section: Morphometrymentioning

confidence: 79%

Macro- and Microstructure of the Superior Cervical Ganglion in Dogs, Cats and Horses during Maturation

Fioretto

Abreu

Castro

et al. 2007

Cells Tissues Organs

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“…The nucleus-cytoplasm ratio of the CMG neurons decreases with aging, as stated by Ledda et al (2000). This ratio decreases when the area occupied by the cytoplasm in either adults or aged is larger than the area occupied in pups, or when the area occupied by the nucleus in either adults or aged is smaller than those occupied in pups, or by means of the association of these two factors.…”

Section: Morphometric Studymentioning

confidence: 86%

Postnatal‐related changes in the size and total number of neurons in the caudal mesenteric ganglion of dogs: Total number of neurons can be predicted from body weight and ganglion volume

et al. 2005

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Aging is mostly characterized by a progressive decline of neuronal function that involves both the central and the peripheral nervous system. The aging process is accompanied by changes in either the number or the size of neurons. However, these data are controversial and not very well known in the sympathetic ganglia of large mammals. Hence, the present investigation aimed to study the dog's caudal mesenteric ganglion (CMG) in three different periods of postnatal development, searching for qualitative and quantitative alterations. The CMG is responsible for the large intestine, internal anal sphincter, and partially the urogenital system innervations. Nine dead male dogs from the Veterinary Hospital of the College of Veterinary Medicine at University of São Paulo were divided into three well-defined age groups (1-2 months old, 1-2 years old, and 5-10 years old). The stereological study was pursued using the physical disector method combined to the Cavalieri principle. The postnatal development was accompanied by an increase in the nonneuronal tissue amount and in ganglion volume. Additionally, the total number of neurons also increased during aging (from 70,140 to 1,204,516), although the neuronal density showed an opposite trend (from 29,911 to 11,500 mm Ϫ3 ). Due to the interrelation between either body weight or ganglion volume and aging in the dogs investigated in this study, it was possible to predict the total number of neurons in CMG using both body weight and ganglion volume in an attempt to verify whether or not size and total number of neurons are both allometrically and aging ruled, i.e., if either the animal's body weight and ganglion volume or aging influence these parameters. The prediction of the total number of neurons was very close to the initially estimated values.

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“…With regard to changes in the percentage of perikaryal volume occupied by mitochondria with advancing age, conflicting data are present in the literature. The volume ratio between nucleus and perikaryal cytoplasm has been observed to decrease with age in various types of neuron (Silverman and Sladek 1991;Peinado et al 1993;Ledda et al 2000). This decrease is not the consequence of the perikaryal enlargement due to lipofuscin accumulation, although its causes remain unclear.…”

mentioning

confidence: 97%

Morphological changes in nerve cells during normal aging

Pannese¹

2011

Brain Struct Funct

170

108

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During normal aging, widespread loss of nerve cells does not occur. Neuronal loss is limited to restricted regions of the nervous system and is slight (probably no more than 10%). The commonest age-related structural changes undergone by nerve cells are as follows: dendrites decrease in number and length and many dendritic spines are lost; axons decrease in number and their myelin sheaths may become less compact and undergo segmental demyelination followed by remyelination; and significant loss of synapses occurs. These changes probably make a significant contribution to the behavioral impairment and cognitive decline that often accompany normal aging.

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Decrease in the nucleo-cytoplasmic volume ratio of rabbit spinal ganglion neurons with age

Cited by 12 publications

References 10 publications

Macro- and Microstructure of the Superior Cervical Ganglion in Dogs, Cats and Horses during Maturation

Macro- and Microstructure of the Superior Cervical Ganglion in Dogs, Cats and Horses during Maturation

Postnatal‐related changes in the size and total number of neurons in the caudal mesenteric ganglion of dogs: Total number of neurons can be predicted from body weight and ganglion volume

Morphological changes in nerve cells during normal aging

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