Decrease in toe pinch force in male type 2 diabetic patients with diabetic nephropathy

Kataoka, Hironao; Miyatake, Nobuyuki; Kitayama, Naomi; Murao, Satoshi; Tanaka, Satoshi

doi:10.1007/s10157-017-1507-5

Cited by 5 publications

(3 citation statements)

References 30 publications

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“…This phenomenon occurs even in patients with mild renal impairment [29]. Furthermore, trace albuminuria is associated with endothelial dysfunction, sarcopenia, and muscle strength [30–32], suggesting that peripheral tissue abnormalities may also affect fatigability in early-stage patients, such as our participants. In other words, the complications of DKD contribute to the process of increased fatigability in T2DM and enhance fatigability by inducing biological changes in peripheral tissues due to the complications of CKD.…”

Section: Discussionmentioning

confidence: 93%

Effect of diabetic kidney disease complications on fatigability in patients with type 2 diabetes mellitus

Hirano,

Tsuriya,

Kono

et al. 2024

Preprint

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Purpose: Type 2 diabetes mellitus (T2DM) emphasizes the maintenance of high levels of physical activity and requires interventions tailored to the characteristics of each patient. We hypothesized that T2DM combined with diabetic kidney disease (DKD) could increase skeletal muscle fatigability, becoming a specific contributor to physical inactivity. This study aimed to determine the effects of DKD complications on fatigability and the relationship between fatigability and physical activity in patients with T2DM. Methods: The participants were 50 patients with T2DM aged 40–65 years with an estimated glomerular filtration rate of 30 ml/min/1.73 m2 or higher. An experimental protocol was performed using a isokinetic dynamometer to assess muscle function. Fatigability (maximal voluntary concentric contraction [ΔMVCC] velocity, maximal voluntary isometric contraction [ΔMVIC] torque) was calculated, indicating the decrease in angular velocity and muscle strength associated with the exercise task. The patient characteristics, physical activity (IPAQ-SV), knee extension strength, and skeletal muscle index were evaluated. Participants were divided into two groups (DKD and non-DKD) according to the presence or absence of DKD, and ΔMVCC velocity and ΔMVIC torque were compared. Results: ΔMVCC velocity was significantly higher in the DKD group than that in the non-DKD group (p<0.05). Similarly, ΔMVIC torque was significantly higher in the DKD group compared with the non-DKD group (p<0.05). Subgroup analysis showed that ΔMVCC velocity was independently associated with physical activity in the DKD group (odds ratio: 0.045, 95% confidence interval: 0.913–0.999). Conclusion: Fatigability increased with DKD in patients with T2DM and may be related to physical activity.

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Section: Discussionmentioning

confidence: 93%

Effect of diabetic kidney disease complications on fatigability in patients with type 2 diabetes mellitus

Hirano,

Tsuriya,

Kono

et al. 2024

Preprint

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“…The cross-sectional studies using MRI have reported that DPN is associated with reduced muscle mass [ 33 ] and increased intramuscular fat [ 32 ] compared with those without DPN. A previous cross-sectional study using foot muscle strength as an outcome, which included only male patients with T2DM, reported that toe pinch force was reduced by having DPN [ 14 ]. However, it should be noted that the study subjects were only males and that adjustment for confounding factors was insufficient, with adjustment only for age and BMI.…”

Section: Discussionmentioning

confidence: 99%

The impact of diabetic polyneuropathy on toe grip strength in patients with type 2 diabetes mellitus: a cross-sectional study

Yoshida

Miura

Nakanishi

et al. 2023

J Diabetes Metab Disord

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Purpose Type 2 diabetes mellitus (T2DM) and concomitant diabetic polyneuropathy (DPN) induce muscle weakness. Muscle weakness in the foot is associated with foot deformities and falls. However, factors affecting toe grip strength (TGS) are not well known. Therefore, the present study investigated factors related to TGS in patients with T2DM. Methods This was a cross-sectional study involving 100 patients with T2DM who were hospitalized for the treatment of T2DM and 50 healthy adults. The subjects were divided into three groups: a group of healthy subjects, a group of T2DM patients without DPN, and a group of T2DM patients with DPN. Hierarchical multiple regression analysis was performed with TGS and the TGS-to-weight ratio (TGS/Wt%) as dependent variables and with age, the presence of T2DM, and DPN as independent variables, and sex and BMI as confounders. Results There were no significant differences in age or sex among the three groups. In the final regression analysis, age and presence of T2DM and DPN were associated in both models with TGS and TGS/Wt% as dependent variables. Conclusion DPN, T2DM, and age were found to be related to TGS. The findings of this study could contribute to healthcare providers developing foot care and rehabilitation programs for diabetic patients. Trial registration This study was registered with UMIN-CTR (UMIN000034320) on 1 November 2018.

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“…Previously, we compared TPF between patients with T2DM and healthy individuals, and our findings showed that the TPF in patients with T2DM was significantly lower than that in healthy individuals, indicating that diabetes is strongly associated with TPF reduction [ 15 ]. In addition, a previous study investigating TPF in patients with diabetic nephropathy of stages 1 to 3 has shown that diabetic nephropathy is strongly associated with toe muscle weakness [ 30 ]. Thus, the further decrease in TPF in chronic hemodialysis patients with T2DM in this study is expected.…”

Section: Discussionmentioning

confidence: 99%

The Association between Chronic Hemodialysis and Toe Pinch Force in Japanese Patients: Cross-Sectional Study

Kataoka

Miyatake

Matsuda³

et al. 2021

Healthcare

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The purpose of this cross-sectional study was to investigate the effect of chronic hemodialysis on toe pinch force (TPF). A total of 37 chronic hemodialysis patients without type 2 diabetes mellitus (T2DM) (age: 69.4 ± 11.8 years, duration of hemodialysis: 3.5 ± 3.4 years) were enrolled in this study. The TPF in chronic hemodialysis patients without T2DM was compared with that in 34 apparently healthy participants and 37 chronic hemodialysis patients with T2DM. There was no significant difference in clinical profiles between healthy participants and chronic hemodialysis patients with and without T2DM. The TPF in chronic hemodialysis patients without T2DM was lower compared with that in healthy participants (2.70 ± 1.05 kg vs. 3.34 ± 0.99 kg, p = 0.025). In addition, the TPF in patients with T2DM was even lower compared with that in patients without T2DM (2.12 ± 1.01 kg vs. 2.70 ± 1.05 kg, p = 0.042). This study showed a dramatic reduction in TPF in chronic hemodialysis patients, especially in those with T2DM.

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Decrease in toe pinch force in male type 2 diabetic patients with diabetic nephropathy

Abstract: We found in male patients with diabetic nephropathy, the TPF and KEF decreased with progression of diabetic nephropathy. Furthermore, our findings suggest diabetic nephropathy and DPN are critically involved in the reduction of TPF and KEF.

Cited by 5 publications

References 30 publications

Effect of diabetic kidney disease complications on fatigability in patients with type 2 diabetes mellitus

Effect of diabetic kidney disease complications on fatigability in patients with type 2 diabetes mellitus

The impact of diabetic polyneuropathy on toe grip strength in patients with type 2 diabetes mellitus: a cross-sectional study

The Association between Chronic Hemodialysis and Toe Pinch Force in Japanese Patients: Cross-Sectional Study

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