Decrease of carbon tetrachloride liver toxicity in rats given Dipyridamole

Kast, A; Nishikawa, Junsuke; Yabe, Takeshi

doi:10.1016/s0232-1513(82)80061-3

Cited by 2 publications

(1 citation statement)

References 26 publications

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“…[57][58][59] Many of these effects of dipyridamole could be important in the amelioration of fibrogenesis lipids and subsequent necrosis. The production or removal of these oxidation products may be altered by DES, leading to in the D-C rabbit model.…”

Section: Aid Hepa 0023mentioning

confidence: 99%

Hepatic Sinusoidal Fibrosis Induced by Cholesterol and Stilbestrol in the Rabbit: 1. Morphology and Inhibition of Fibrogenesis by Dipyridamole

1996

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tween individual animals. It has been shown that rabbits This study documents the hepatic morphology and the that are given CHOL simultaneously with diethylstilbestrol ultrastructure of a model of hepatic fibrosis in rabbits.(DES) rapidly develop hepatic fibrosis over a period of several Rabbits were given a cholesterol-supplemented diet weeks, 6-8 but this model has not been studied in detail. The (1%), a stilbestrol diet (10 mg subcutaneously twice a present report describes the hepatic morphology, the ultraweek), or both treatments simultaneously for 7 weeks.structure, and the hepatic collagen content following this Rabbits given the combined treatment developed sinu- The treatments were given for 7 weeks, at which point the animals were killed. One D-C rabbit died before the completion of the study. Hepatic fibrosis develops in a variety of mammals that areThe liver and spleen were exposed under sodium pentobarbital anesfed a cholesterol (CHOL)-supplemented diet.1-5 However, in thesia without prior fasting, and samples were excised, diced, and most species, including the rabbit, the fibrosis is mild, re-fixed by immersion in cold 2.5% glutaraldehyde buffered with 0.1 quires many months to develop, and is highly variable be-mol/L of cacodylate at pH 7.2. This tissue was later postfixed with osmium tetroxide, embedded in Epon 812, and the sections were stained with lead citrate and uranyl acetate. The spleens were cut Abbreviations: CHOL, cholesterol; D-C, diethylstilbestrol-cholesterol; DES, diethylstilinto 5-mm slices and allowed to drain on absorbent paper before bestrol.weighing. The liver slices were fixed in buffered 4% formaldehyde,

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Section: Aid Hepa 0023mentioning

confidence: 99%

Hepatic Sinusoidal Fibrosis Induced by Cholesterol and Stilbestrol in the Rabbit: 1. Morphology and Inhibition of Fibrogenesis by Dipyridamole

1996

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Stress Perfusion Imaging Of The Celiac Axis Using Turboflash MRI

2000

IJRA

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The purpose of this study was to evaluate the ability of cardiac gated Turbo-FLASH MRI to measure the effect of Dipyridamole (DP) on perfusion of the stomach, spleen and liver in patients undergoing DP stress and to establish reproducibility of this technique for the eventual application in screening for mesenteric ischemia, which was briefly evaluated at the splenic flexure of the colon in this work. Turbo-FLASH can provide adequate time and spatial resolution in intra-abdominal perfusion MRI with reproducible changes in hepatic, splenic and gastric perfusion during DP stress. The changes in organ perfusion after DP appear to be intrinsic to the vascular effects of DP and may have clinical importance. Sample size calculation indicates that a controlled study with 165 normals and 165 subjects will be necessary to detect a 20% difference in perfusion between the groups with a power of 0.8.

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Decrease of carbon tetrachloride liver toxicity in rats given Dipyridamole

Cited by 2 publications

References 26 publications

Hepatic Sinusoidal Fibrosis Induced by Cholesterol and Stilbestrol in the Rabbit: 1. Morphology and Inhibition of Fibrogenesis by Dipyridamole

Hepatic Sinusoidal Fibrosis Induced by Cholesterol and Stilbestrol in the Rabbit: 1. Morphology and Inhibition of Fibrogenesis by Dipyridamole

Stress Perfusion Imaging Of The Celiac Axis Using Turboflash MRI

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