Decrease of delta oscillatory responses is associated with increased age in healthy elderly

Emek‐Savaş, Derya Durusu; Güntekin, Bahar; Yener, Görsev; Başar, Erol

doi:10.1016/j.ijpsycho.2015.02.006

Cited by 21 publications

(10 citation statements)

References 72 publications

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“…In a recent study on aging, event-related delta responses in the parietal cortex were found to be decreased in accordance with age [ 47 ]. Also, another previous study on schizophrenia has revealed increased delta power in schizophrenia patients as compared with normal controls [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Increased parietal circuit-breaker activity in delta frequency band and abnormal delta/theta band connectivity in salience network in hyperacusis subjects

et al. 2018

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Recent studies have suggested that hyperacusis, an abnormal hypersensitivity to ordinary environmental sounds, may be characterized by certain resting-state cortical oscillatory patterns, even with no sound stimulus. However, previous studies are limited in that most studied subjects with other comorbidities that may have affected cortical activity. In this regard, to assess ongoing cortical oscillatory activity in idiopathic hyperacusis patients with no comorbidities, we compared differences in resting-state cortical oscillatory patterns between five idiopathic hyperacusis subjects and five normal controls. The hyperacusis group demonstrated significantly higher electrical activity in the right auditory-related cortex for the gamma frequency band and left superior parietal lobule (SPL) for the delta frequency band versus the control group. The hyperacusis group also showed significantly decreased functional connectivity between the left auditory cortex (AC) and left orbitofrontal cortex (OFC), between the left AC and left subgenual anterior cingulate cortex (sgACC) for the gamma band, and between the right insula and bilateral dorsal anterior cingulate cortex (dACC) and between the left AC and left sgACC for the theta band versus the control group. The higher electrical activity in the SPL may indicate a readiness of “circuit-breaker” activity to shift attention to forthcoming sound stimuli. Also, because of the disrupted salience network, consisting of the dACC and insula, abnormally increased salience to all sound stimuli may emerge, as a consequence of decreased top-down control of the AC by the dACC and dysfunctional emotional weight attached to auditory stimuli by the OFC. Taken together, abnormally enhanced attention and salience to forthcoming sound stimuli may render hyperacusis subjects hyperresponsive to non-noxious auditory stimuli.

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Section: Discussionmentioning

confidence: 99%

Increased parietal circuit-breaker activity in delta frequency band and abnormal delta/theta band connectivity in salience network in hyperacusis subjects

et al. 2018

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“…It seems that aging also induces delta abnormalities in oddball paradigms. In particular, delta event-related responses decrease with age, specifically across frontoparietal regions during visual oddball tasks [41]. Aging is also associated with other frequency-specific changes in oscillatory activity during oddball tasks, including a P300-related enhancement in theta oscillations in medial fron toparietal areas, along with increased prefrontal alpha activity in healthy middle-aged subjects compared to younger individuals [42].…”

Section: Aging and Cortical Oscillationsmentioning

confidence: 99%

Healthy and Pathological Brain Aging: From the Perspective of Oscillations, Functional Connectivity, and Signal Complexity

et al. 2017

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Healthy aging is associated with impairment in cognitive information processing. Several neuroimaging methods such as functional magnetic resonance imaging, positron emission tomography and near-infrared spectroscopy have been used to explore healthy and pathological aging by relying on hemodynamic or metabolic changes that occur in response to brain activity. Since electroencephalography (EEG) and magnetoencephalography (MEG) are able to measure neural activity directly with a high temporal resolution of milliseconds, these neurophysiological techniques are particularly important to investigate the dynamics of brain activity underlying neurocognitive aging. It is well known that age is a major risk factor for Alzheimer’s disease (AD), and that synaptic dysfunction represents an early sign of this disease associated with hallmark neuropathological findings. However, the neurophysiological mechanisms underlying AD are not fully elucidated. This review addresses healthy and pathological brain aging from a neurophysiological perspective, focusing on oscillatory activity changes during the resting state, event-related potentials and stimulus-induced oscillatory responses during cognitive or motor tasks, functional connectivity between brain regions, and changes in signal complexity. We also highlight the accumulating evidence on age-related EEG/MEG changes and biological markers of brain neurodegeneration, including genetic factors, structural abnormalities on magnetic resonance images, and the biochemical changes associated with Aβ deposition and tau pathology.

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“…7,[30][31][32][33] Delta ERO reductions have also been reported in other disorders with cognitive dysfunction such as AD, 9 MCI, 8,16 schizophrenia, 34 bipolar disorder, 35 as well as in physiological aging. 36 The literature on ERO is scarce, but event-related potential (ERP) studies on PD date back to the 1980s. Early studies indicate that delta and theta ERO responses are the main components of P300.…”

Section: Decreased Visual Delta Ero In Pd Patientsmentioning

confidence: 99%

Decrease of Delta Oscillatory Responses in Cognitively Normal Parkinson’s Disease

et al. 2016

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Parkinson's disease (PD) is a common progressive neurodegenerative disorder. This study aims to compare sensory-evoked oscillations (SEOs) and event-related oscillations (EROs) of visual modality in cognitively normal PD patients and healthy controls. Sixteen PD and 16 age-, gender-, and education-matched healthy controls participated in the study. A simple flashlight was used for SEO and a classical visual oddball paradigm was used for target ERO. Oscillatory responses in the delta frequency range (0.5-3.5 Hz) were examined. Significantly lower delta ERO and SEO responses were found in PD patients than healthy controls. Delta ERO responses were decreased at all frontal, central and parietal locations, whereas delta SEO responses were decreased over mid and right central locations in PD. According to the notion that SEO reflects the activity of sensory networks and ERO reflects cognitive networks, these findings indicate that PD patients have impairments in both cognitive and sensory networks of visual modality. Decreased delta ERO responses indicate that the subliminal cognitive changes in PD can be detected by electrophysiological methods. These results demonstrate that brain oscillatory responses have the potential to be studied as a biomarker for visual cognitive and sensory networks in PD.

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Decrease of delta oscillatory responses is associated with increased age in healthy elderly

Cited by 21 publications

References 72 publications

Increased parietal circuit-breaker activity in delta frequency band and abnormal delta/theta band connectivity in salience network in hyperacusis subjects

Increased parietal circuit-breaker activity in delta frequency band and abnormal delta/theta band connectivity in salience network in hyperacusis subjects

Healthy and Pathological Brain Aging: From the Perspective of Oscillations, Functional Connectivity, and Signal Complexity

Decrease of Delta Oscillatory Responses in Cognitively Normal Parkinson’s Disease

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