Decrease of nasal airway resistance and alleviations of symptoms after balloon sinuplasty in patients with isolated chronic rhinosinusitis: a prospective, randomised clinical study

Abstract

Both balloon sinuplasty and uncinectomy improved the quality of life and decreased upper airway resistance of patients with mild, isolated chronic or recurrent rhinosinusitis. The smaller risk of postoperative synechiae with balloon sinuplasty combined with its promising efficiency could partially compensate for its high material cost.

Treatment of rhinosinusitis and histopathology of nasal mucosa: A controlled, randomized, clinical study

“…The decreased number of inflammatory cells, alleviation of mucosal hypervascularity, and decline in the hypertrophy of mucous glands may account for a more functional nasal epithelium and lower nasal airway resistance. In the uncinectomy group, there was a noticeable decrease in mucosal edema 6 months after treatment, which may in part account for the decreased nasal airway resistance at that timepoint …”

“…In the uncinectomy group, the SNOT‐22 scores were 45.63 ± 3.29 (before treatment), 24.25 ± 2.68 (3 months after treatment), 30.54 ± 3.2 (6 months after treatment), and 30.59 ± 2.6 (12 months after treatment). In the balloon sinuplasty group, the corresponding scores were 42.70 ± 3.2 (before treatment), 23.31 ± 2.72 (3 months after treatment), 25.31 ± 3.81 (6 months after treatment), and 27.47 ± 4.1 (12 months after treatment) …”

“…In the balloon sinuplasty group, the corresponding scores were 42.70 6 3.2 (before treatment), 23.31 6 2.72 (3 months after treatment), 25.31 6 3.81 (6 months after treatment), and 27.47 6 4.1 (12 months after treatment). 23,26 The damage of cilia was associated with a higher SNOT-22 at 3 months after treatment (r 5 0 0.329, P 5 0.002). A higher number of mucosal glands (r 5 0.369) and goblet cells (r 5 0.354) was associated with a greater total SNOT-22 score at 12 months after treatment.…”

“…In the uncinectomy group, there was a noticeable decrease in mucosal edema 6 months after treatment, which may in part account for the decreased nasal airway resistance at that timepoint. 23,25,26…”

“…In previous studies, ESS is followed by an improvement in both subjective and objective findings and an improvement in the quality of life of patients. [22][23][24][25][26] The aims of this clinical study were to study and document the effects of treatment on the histopathology of nasal mucosa in patients, as well as on the expression of metalloproteinase 9 (MMP-9).…”