Decrease of plasma fibronectin concentration following infusion of a gelatin-based plasma substitute in man

Brodin, B; Hesselvik, F.; Schenck, H von

doi:10.1080/00365518409083606

Cited by 32 publications

(4 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This cannot be explained by differences in haemodilution. Brodin et al studied healthy adults and found that 500 ml gelatin-based plasma substitute, HaemaccelB resulted in significant plasma fibronectin depletion 48 h and 72 h after infusion, whereas the dextran-based plasma substitute, MacrodexB, did not have this effect (16). We found the same phenomenon in our surgical patients.…”

Section: Discussionsupporting

confidence: 81%

Effects of different plasma substitutes on plasma fibronectin concentrations in patients undergoing abdominal surgery

Perttilä

Salo

Peltola

1990

Acta Anaesthesiol Scand

View full text Add to dashboard Cite

Plasma fibronectin is important for host defences as an opsonin of the mononuclear phagocyte system (MPS). The effects of three types of plasma substitutes, crystalloid, gelatin and dextran solutions, on plasma fibronectin levels were studied in patients undergoing abdominal surgery in relation to serum total protein and serum C-reactive protein (CRP) levels. Plasma fibronectin levels decreased during induction of anaesthesia and infusion of an electrolyte solution before infusion of the plasma substitute, and they were further decreased during operation after infusion of plasma substitutes and remained depressed on the first postoperative day in all study groups (P less than 0.05-0.01). In the crystalloid and dextran groups, plasma fibronectin levels exceeded preoperative levels by the 4th-5th postoperative day (P less than 0.05-0.01), but in the gelatin solution group they remained depressed (P less than 0.01). Serum total protein levels remained lower than preoperative values throughout the study period (P less than 0.05-0.01), whereas CRP levels were many times higher on days 1 and 4-5 postoperatively in all groups (P less than 0.01).

show abstract

Section: Discussionsupporting

confidence: 81%

Effects of different plasma substitutes on plasma fibronectin concentrations in patients undergoing abdominal surgery

Perttilä

Salo

Peltola

1990

Acta Anaesthesiol Scand

View full text Add to dashboard Cite

show abstract

“…We previously found that the gelatin-derived plasma substitute could block the plasma opsonic activity, and in this study, we were able to demonstrate electrophoretically the interaction of this material with fibronectin. Other workers have reported a decrease in plasma fibronectin following infusion of this material (34).…”

Section: Discussionmentioning

confidence: 55%

Characterization of the molecular forms of fibronectin in fulminant hepatic failure

Almasio¹,

Hughes²,

Williams³

1986

Hepatology

View full text Add to dashboard Cite

The plasma levels of the opsonic glycoprotein fibronectin are decreased in patients with fulminant hepatic failure, which may be an important factor in their impaired host-defense. Twenty-nine patients in fulminant hepatic failure were studied on admission, and the mean fibronectin level in Grade 0-2 encephalopathy was 82 micrograms per ml (range = 0 to 150) and in Grade 3-4 encephalopathy 61 micrograms per ml (range = 5 to 158) as compared to normal controls (268 micrograms per ml, range = 178 to 380, n = 62). No fibronectin degradation products could be detected in fulminant hepatic failure plasma by sodium dodecyl sulfate-gel electrophoresis on a polyacrylamide gradient (5 to 15%) followed by immunoblotting onto nitrocellulose with detection using a rabbit antihuman fibronectin antiserum visualized with a peroxidase conjugate. The plasma levels of the marker proteolytic enzyme cathepsin D were significantly elevated in fulminant hepatic failure (120 +/- 31 mU per ml per hr) as compared to the normal controls (18 +/- 2.1 mU per ml per hr, n = 10, p less than 0.01). Cross-immunoelectrophoresis of fulminant hepatic failure plasma for fibronectin on agarose plates gave an additional slower migrating peak in 15 of the 29 patients, as well as that of fibronectin, which corresponded to the fibronectin complex reported by other workers in leukemia. An intermediate gel containing antihuman fibrinogen demonstrated fibrinogen to be one component of this complex. Binding of other substances to fibronectin will reduce its apparent biological activity and may be the result of their lack of clearance by the damaged liver.

show abstract

“…Nevertheless, normovolemia can be achieved when initially higher amounts of gelatin (1.5-2 times the volume loss) are infused; to maintain normovolemia, reinfusions are needed more frequently. Apart from the dilutional fall of the red cell concentration [22], it seems necessary to limit the quantity of gelatin solution that can be given because gelatin reduces the optimizing function of fibronectin [23]. Neither specific effects on the blood clotting mechanism nor antithrombotic properties of gelatins have been demonstrated (for side effects, see below).…”

Section: Gelatinmentioning

confidence: 99%

The use of plasma substitutes with special attention to their side effects

Meßmer

1987

World j. surg.

View full text Add to dashboard Cite

Plasma protein fraction and human serum albumin are suitable for plasma replacement; however, they are in short supply and extremely expensive. Fresh-frozen plasma should not be used for volume replacement, but for documented coagulation protein deficiencies and for patients who require massive blood transfusions. Artificial colloids are free from the risk of transmitting diseases and easy to provide at low costs. The intravascular volume effect of colloid solutions based on dextran, gelatin, or hydroxyethyl starch depends on the physicochemical characteristics of the polymer solution. For the given colloid, the half-life varies from 2 to 8 hours. In addition to the volume effect, dextran provides specific antithrombotic properties. None of the colloids are free from the risk of untoward effects, such as anaphylactoid/anaphylactic reactions. The low frequency of these reactions and the possibility to prevent and to treat them justifies the use of artificial colloids on a routine basis for shock treatment, volume support, and perioperative hemodilution.

show abstract

Decrease of plasma fibronectin concentration following infusion of a gelatin-based plasma substitute in man

Cited by 32 publications

References 10 publications

Effects of different plasma substitutes on plasma fibronectin concentrations in patients undergoing abdominal surgery

Effects of different plasma substitutes on plasma fibronectin concentrations in patients undergoing abdominal surgery

Characterization of the molecular forms of fibronectin in fulminant hepatic failure

The use of plasma substitutes with special attention to their side effects

Contact Info

Product

Resources

About