Decrease of superficial serine and lactate in the stratum corneum due to repetitive frictional trauma

Wong, Lai‐San; Otsuka, Atsushi; Tanizaki, Hideaki; Nonomura, Yumi; Nakashima, Chisa; Yamamoto, Yosuke; Yen, Yu Ta; Rerknimitr, Pawinee; Honda, Tetsuya; Kabashima, Kenji

doi:10.1111/ijd.13856

Cited by 5 publications

(5 citation statements)

References 22 publications

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“…Threonine was the only exception. The overall decrease in the serine levels was consistent with previous results in AD 59–61 . Serine condensates with FA‐CoAs by serine palmitoyl transferase (SPT), which is the rate‐limiting enzyme in sphingolipid synthesis 62 .…”

Section: Discussionsupporting

confidence: 89%

“…The overall decrease in the serine levels was consistent with previous results in AD. [59][60][61] Serine condensates with FA-CoAs by serine palmitoyl transferase (SPT), which is the rate-limiting enzyme in sphingolipid synthesis. 62 Whether the lower level of serine in the SC in AD patients is linked with the altered ceramide composition awaits clarification.…”

Section: Discussionmentioning

confidence: 99%

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Biosignatures of defective sebaceous gland activity in sebum‐rich and sebum‐poor skin areas in adult atopic dermatitis

Cavallo,

Camera,

Bottillo

et al. 2024

Experimental Dermatology

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Atopic dermatitis (AD) is a composite disease presenting disruption of the skin permeability barrier (SPB) in the stratum corneum (SC). Recent evidence supports derangement of the sebaceous gland (SG) activity in the AD pathomechanisms. The objective of this study was to delineate profiles of both sebaceous and epidermal lipids and of aminoacids from SG‐rich (SGR) and SG‐poor (SGP) areas in AD. Both sebum and SC were sampled from SGR areas, while SC was sampled also from SGP areas in 54 adult patients with AD, consisting of 34 and 20 subjects, respectively with and without clinical involvement of face, and in 44 age and sex‐matched controls. Skin biophysics were assessed in all sampling sites. Disruption of the SBP was found to be associated with dysregulated lipidome. Abundance of sapienate and lignocerate, representing, respectively, sebum and the SC type lipids, were decreased in sebum and SC from both SGR and SGP areas. Analogously, squalene was significantly diminished in AD, regardless the site. Extent of lipid derangement in SGR areas was correlated with the AD severity. The abundance of aminoacids in the SC from SGR areas was altered more than that determined in SGP areas. Several gender‐related differences were found in both controls and AD subgroups. In conclusion, the SG activity was differently compromised in adult females and males with AD, in both SGR and SGP areas. In AD, alterations in the aminoacidome profiles were apparent in the SGR areas. Lipid signatures in association with aminoacidome and skin physical properties may serve the definition of phenotype clusters that associate with AD severity and gender.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Biosignatures of defective sebaceous gland activity in sebum‐rich and sebum‐poor skin areas in adult atopic dermatitis

Cavallo,

Camera,

Bottillo

et al. 2024

Experimental Dermatology

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“…Spectroscopic methods have also been utilized to measure lactate concentrations for in-vivo biomedical applications [ 125 , 130 , 131 , 132 , 133 , 134 , 135 , 136 ]. These are commonly used as a non-invasive method of measurement for dermatological analysis where a low-power laser beam in the near infrared range was placed on the skin using an optical fiber or directly scanned over the surface and the resulting reflected light collected and analyzed for the presence of lactate or other analytes.…”

Section: Lactate Sensor Transduction Mechanismsmentioning

confidence: 99%

“…The investigation of the molecular composition of the stratum corneum, which is the outermost layer of the skin, using confocal Raman spectroscopy was able to detect the presence of lactate but further details were not provided [ 130 ]. Other studies using spectroscopic methods have also reported being able to detect changes in the amount of lactate over time or in a given area but do not report whether they can measure the actual concentration [ 134 , 136 ]. A recent study was able to produce maps of the concentration per volume of the constituents of the stratum corneum, such as water, lactate, and lipids.…”

Section: Lactate Sensor Transduction Mechanismsmentioning

confidence: 99%

Sensors for Fetal Hypoxia and Metabolic Acidosis: A Review

Cummins

Kremer

Bernassau

et al. 2018

Sensors

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This article reviews existing clinical practices and sensor research undertaken to monitor fetal well-being during labour. Current clinical practices that include fetal heart rate monitoring and fetal scalp blood sampling are shown to be either inadequate or time-consuming. Monitoring of lactate in blood is identified as a potential alternative for intrapartum fetal monitoring due to its ability to distinguish between different types of acidosis. A literature review from a medical and technical perspective is presented to identify the current advancements in the field of lactate sensors for this application. It is concluded that a less invasive and a more continuous monitoring device is required to fulfill the clinical needs of intrapartum fetal monitoring. Potential specifications for such a system are also presented in this paper.

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“…Friction can also involve the mucosae [1][2][3][4] hair [5][6][7][8] and nails. 9,10 Frictional dermatoses is an under-recognised entity with no clear-cut definition. The authors propose to define frictional dermatoses as 'a group of disorders caused by repetitive trauma to the skin as a result of friction of varying aetiology which can have a wide range of cutaneous manifestations depending on the type of insult.…”

Section: Introductionmentioning

confidence: 99%

Current understanding of frictional dermatoses: A review

Arora¹,

Khandpur

Bansal

et al. 2022

IJDVL

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Human skin is continually exposed to internal and external forces, dynamic as well as static. The skin is normally flexible and can resist mechanical trauma due to friction, pressure, vibration, suction and laceration to a considerable degree. However, an excess of these forces can abnormally affect the structure and function of the skin, setting the stage for the development of a skin disorder. Repetitive trauma can cause lichenification, hyperpigmentation, erythema, scaling, fissuring, blisters, ulceration and chronic alterations. Frictional dermatoses is an under-recognised entity with no clear-cut definition and encompasses a variety of terms such as frictional dermatitis, frictional melanosis, frictional pigmentary dermatoses and certain other named entities, many of which are confusing. The authors propose to define frictional dermatoses as ‘a group of disorders caused by repetitive trauma to the skin as a result of friction of varied aetiology which can have a wide range of cutaneous manifestations depending on the type of insult.’ The exact prevalence of frictional dermatoses as a separate entity is unknown. Authors who conducted this review include a group of dermatologists and post graduate students from various institutions. Literature was reviewed through PubMed, Medscape, Medline, ResearchGate and Google Scholar using the terms ‘frictional dermatitis,’ ‘friction and skin,’ ‘dermatoses and culture,’ ‘clothing dermatitis,’ ‘friction melanosis,’ ‘PPE induced dermatoses in COVID-19 era,’ etc. A total of 122 articles were reviewed and 100 articles among them were shortlisted and included in the study, after removing duplications. The review was followed up with further deliberation which resulted in the formulation of a new definition and classification of frictional dermatoses taking into account the morphology, histopathological characteristics, anatomical region affected and the major predisposing factors. The rising incidence of mechanical dermatoses in the COVID-19 era was also emphasised.

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Decrease of superficial serine and lactate in the stratum corneum due to repetitive frictional trauma

Abstract: Increased TEWL and decreased NMF are considered as an etiology of atopic dermatitis (AD); therefore, our findings provide evidence that daily activities with repetitive frictional trauma may be related to the predisposition of AD.

Cited by 5 publications

References 22 publications

Biosignatures of defective sebaceous gland activity in sebum‐rich and sebum‐poor skin areas in adult atopic dermatitis

Biosignatures of defective sebaceous gland activity in sebum‐rich and sebum‐poor skin areas in adult atopic dermatitis

Sensors for Fetal Hypoxia and Metabolic Acidosis: A Review

Current understanding of frictional dermatoses: A review

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