2006
DOI: 10.1016/j.actatropica.2005.12.004
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Decrease of type IV collagen and TIMP-1 serum levels after splenectomy in patients with schistosomiasis mansoni

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Cited by 8 publications
(4 citation statements)
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“…The rebleeding rate of 16.7% in this study was consistent with other séries 12,21,29,31 and appears to be related to the degree of fibrosis 4 , more intensely marked by thrombocytopenia 33 . This claim is disputed by other authors 2 , which relate the severity of hepatosplenic schistosomiasis to intrahepatic sinusoidal obstruction and not to fibrosis.…”
Section: Discussionsupporting
confidence: 91%
“…The rebleeding rate of 16.7% in this study was consistent with other séries 12,21,29,31 and appears to be related to the degree of fibrosis 4 , more intensely marked by thrombocytopenia 33 . This claim is disputed by other authors 2 , which relate the severity of hepatosplenic schistosomiasis to intrahepatic sinusoidal obstruction and not to fibrosis.…”
Section: Discussionsupporting
confidence: 91%
“…Two independent groups in China found C-IV to be higher in subjects infected with Schistosoma japonicum (Guangjin et al 2002) and to correlate with re-infection after treatment of schistosomiasis japonica with praziquantel (Li et al 2000). Wyszomirska et al (2005Wyszomirska et al ( , 2006 investigated C-IV for the detection of schistosomiasis-related liver fibrosis in a tertiary care hospital in Brazil. patients had higher levels than controls.…”
Section: Discussionmentioning
confidence: 99%
“…Wyszomirska et al (9) observaram a elevação dos níveis séricos de colágeno tipo IV e da laminina em todas as formas clínicas de esquistossomose. Em outro estudo, Wyszomirska et al (10) encontraram níveis séricos elevados de colágeno tipo IV e TMP1 em pacientes com a forma hepatoesplênica da esquistossomose, com diminuição significativa após a esplenectomia. Mais recentemente, estudos mostraram resultados satisfatórios com o uso de APRI, FIB-4 e métodos de imagem, para a detecção de fibrose, em pacientes portadores de cirrose hepática, podendo ser usados separadamente ou combinados em algoritmos para uma maior precisão diagnóstica (11) Em esquistossomose, os estudos são escassos.…”
Section: Introductionunclassified