Decrease of ventral tegmental area dopamine neuronal activity in nicotine withdrawal rats

Z, Liu; Jin, Wen-Qiao

doi:10.1097/01.wnr.0000126218.25235.b6

Cited by 33 publications

(21 citation statements)

References 18 publications

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“…This association could reflect common adaptation responses to alcohol and tobacco because chronic nicotine also decreases spontaneous activity of VTA DA cells (Liu and Jin, 2004). However, because DA changes did not differ between alcoholic smokers and nonsmokers nor between control smokers and nonsmokers, it is unlikely that the DA reductions were attributable just to smoking but could reflect common vulnerabilities (True et al, 1999;Bierut et al, 2004;Le et al, 2006).…”

Section: Alcohol/nicotine Comorbiditymentioning

confidence: 91%

Profound Decreases in Dopamine Release in Striatum in Detoxified Alcoholics: Possible Orbitofrontal Involvement

Volkow¹,

Wang²,

Telang³

et al. 2007

J. Neurosci.

424

295

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The value of rewards (natural rewards and drugs) is associated with dopamine increases in the nucleus accumbens and varies as a function of context. The prefrontal cortex has been implicated in the context dependency of rewards and in the fixated high value that drugs have in addiction, although the mechanisms are not properly understood. Here we test the hypothesis that the prefrontal cortex regulates the value of rewards by modulating dopamine increases in nucleus accumbens and that this regulation is disrupted in addicted subjects. We used positron emission tomography to evaluate the activity of the prefrontal cortex (measuring brain glucose metabolism with [ In all subjects, methylphenidate significantly increased dopamine in striatum. In ventral striatum (where the nucleus accumbens is located) and in putamen, dopamine increases were associated with the rewarding effects of methylphenidate (drug liking and high) and were profoundly attenuated in alcoholics (70 and 50% lower than controls, respectively). In controls, but not in alcoholics, metabolism in orbitofrontal cortex (region involved with salience attribution) was negatively associated with methylphenidate-induced dopamine increases in ventral striatum. These results are consistent with the hypothesis that the orbitofrontal cortex modulates the value of rewards by regulating the magnitude of dopamine increases in the ventral striatum and that disruption of this regulation may underlie the decreased sensitivity to rewards in addicted subjects.

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Section: Alcohol/nicotine Comorbiditymentioning

confidence: 91%

Profound Decreases in Dopamine Release in Striatum in Detoxified Alcoholics: Possible Orbitofrontal Involvement

Volkow¹,

Wang²,

Telang³

et al. 2007

J. Neurosci.

424

295

View full text Add to dashboard Cite

show abstract

“…ICSS has been proposed as a preclinical model that can be used to model affective-like withdrawal symptoms, because many drugs, including morphine (Schaefer and Michael, 1986;Easterling et al, 2000;Liu and Schulteis, 2004;Altarifi and Negus, 2011;Holtz et al, 2015), nicotine (Epping-Jordan et al, 1998;Cryan et al, 2003;Kenny and Markou, 2005;Igari et al, 2014;Manbeck et al, 2014;Qi et al, 2015), ethanol (Schulteis et al, 1995;Chester et al, 2006;Rylkova et al, 2009;Boutros et al, 2014), and cocaine (Markou and Koob, 1991;Stoker and Markou, 2011), produce decreases in ICSS after either spontaneous or precipitated withdrawal. Furthermore, withdrawal from nicotine and morphine has been associated with decreased ventral tegmental area dopaminergic activity, which correlates with ICSS deficits (Liu and Jin, 2004;Kaufling and Aston-Jones, 2015). Accordingly, this procedure could be used to evaluate potential therapeutics for treating opioid withdrawal.…”

Section: Discussionmentioning

confidence: 99%

Effects of Acute and Repeated Administration of Oxycodone and Naloxone-Precipitated Withdrawal on Intracranial Self-Stimulation in Rats

Wiebelhaus

Walentiny

Beardsley

2016

The Journal of Pharmacology and Experimental Therapeutics

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Incidence of prescription opioid abuse and overdose, often led by oxycodone, continues to increase, producing twice as many overdose deaths as heroin. Surprisingly, preclinical reports relevant to oxycodone's abuse-related effects are relatively sparse considering its history and patient usage. The goal of this study was to characterize dose-and time-dependent effects of acute and repeated oxycodone administration in a frequencyrate intracranial self-stimulation (ICSS) procedure, an assay often predictive of drug-related reinforcing effects, in male Sprague-Dawley rats. We hypothesized that oxycodone would produce a biphasic profile of rate-increasing and ratedecreasing effects maintained by ICSS similar to m-opioid receptor agonists. Oxycodone (0.03, 0.3, 1, and 3 mg/kg, s.c.) produced dose-and time-dependent alterations on ICSS, with the predicted biphasic profile of rate-increasing effects at lower stimulation frequencies followed by rate-decreasing effects at higher frequencies. Peak effects were observed between 30 and 60 minutes, which were reversed by naloxone pretreatment (30 minutes). Tolerance to rate-decreasing effects was observed over a 5-day period when rats were treated with 1 mg/kg oxycodone twice a day. Subsequently, the dosing regimen was increased to 3 mg/kg twice a day over 10 days, although further marked tolerance did not develop. When then challenged with 10 mg/kg naloxone, a significant suppression below baseline levels of ICSS-maintained responding occurred indicative of dependence that recovered to baseline within 5 hours. The results of this study provide the first report of acute and chronic effects of oxycodone on responding maintained by ICSS presentation and the use of ICSS-maintained responding to characterize its tolerance and dependence effects.

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“…Activation of the mesolimbic dopamine system is a feature shared by all classes of abused drugs (Di Chiara and Imperato, 1988) and, much like opiate withdrawal, the electrophysiological activity and neurochemical output of dopamine neurons is reduced during withdrawal from ethanol (Rossetti et al, 1991(Rossetti et al, , 1992Diana et al, 1993;Shen 2003;Rada et al, 2004), nicotine (Hildebrand et al, 1998;Rada et al, 2001;Liu and Jin, 2004), and other stimulants (Parsons et al, 1991;Robertson et al, 1991;Rossetti et al, 1992). Furthermore, reduced dopaminergic signaling in the NAc is associated with emotional signs of nicotine withdrawal (Cryan et al, 2003;Paterson et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Increased Dopamine Receptor Activity in the Nucleus Accumbens Shell Ameliorates Anxiety during Drug Withdrawal

Radke¹,

Gewirtz

2012

Neuropsychopharmacol

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A number of lines of evidence suggest that negative emotional symptoms of withdrawal involve reduced activity in the mesolimbic dopamine system. This study examined the contribution of dopaminergic signaling in structures downstream of the ventral tegmental area to withdrawal from acute morphine exposure, measured as potentiation of the acoustic startle reflex. Systemic administration of the general dopamine receptor agonist apomorphine or a cocktail of the D1-like receptor agonist SKF82958 and the D2-like receptor agonist quinpirole attenuated potentiated startle during morphine withdrawal. This effect was replicated by apomorphine infusion into the nucleus accumbens shell. Finally, apomorphine injection was shown to relieve startle potentiation during nicotine withdrawal and conditioned place aversion to morphine withdrawal. These results suggest that transient activation of the ventral tegmental area mesolimbic dopamine system triggers the expression of anxiety and aversion during withdrawal from multiple classes of abused drugs.

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Decrease of ventral tegmental area dopamine neuronal activity in nicotine withdrawal rats

Cited by 33 publications

References 18 publications

Profound Decreases in Dopamine Release in Striatum in Detoxified Alcoholics: Possible Orbitofrontal Involvement

Profound Decreases in Dopamine Release in Striatum in Detoxified Alcoholics: Possible Orbitofrontal Involvement

Effects of Acute and Repeated Administration of Oxycodone and Naloxone-Precipitated Withdrawal on Intracranial Self-Stimulation in Rats

Increased Dopamine Receptor Activity in the Nucleus Accumbens Shell Ameliorates Anxiety during Drug Withdrawal

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