Decrease Recurrence Rate of Condylomata Acuminata by Photodynamic Therapy Combined with CO₂ Laser in Mainland China: A Meta-Analysis

Abstract

Background: Condylomata acuminata (CA) are caused by human papillomavirus. Most conventional therapies for CA have high recurrence rate. Objectives: To compare the recurrence rate of 5-aminolaevulinic acid photodynamic therapy (ALA-PDT) combined with CO₂ laser and CO₂ laser alone for CA treatment in mainland China. Methods: In this meta-analysis, 2,048 cases of CA from 22 articles were divided into two groups. The treatment group was treated by using ALA-PDT combined with CO₂ laser, and CO₂ laser alone was applied in the control group. The recurrence rate of the two groups was calculated and compared. Results: The recurrence rate was 42.67% (451/1,057) in the control group and 10.29% (102/991) in the treatment group, with a significant statistical difference between the two groups (χ² = 271.98, p < 0.0001). Conclusion: ALA-PDT combined with CO₂ laser was more effective in decreasing the recurrence rate of CA compared with CO₂ laser alone. It might offer a wide clinical application for CA treatment.

Two‐step irradiance schedule versus single‐dose cold compress for pain control during 5‐aminolevulinic acid‐based photodynamic therapy of condyloma acuminatum

“…At present, photodynamic therapy (PDT) of CA and superficial non‐melanocytic skin tumors has been widely applied. It has characteristics of precise targeting, small damage, no drug resistance, non‐toxic side effects, and low recurrence rate . However, pain throughout the course of treatment reduces patients’ compliance, affects its efficacy and limits its application.…”

Successful treatment of refractory genital warts using 0.5% podophyllotoxin‐loaded nanostructured lipid carriers

“…Genital warts are one of the sexually transmitted diseases caused by human papillomavirus (HPV) (Grennan, 2019). There was a high recurrence rate in patients with genital warts after various therapies (Zhu et al, 2012;Grennan, 2019). Recently, 5-aminolaevulinic acidmediated photodynamic therapy (ALA-PDT) exhibited promising efficacy in decreasing the recurrence rate (Zhu et al, 2012).…”

“…Faced with such refractory genital warts, the patient agreed to try 0.5% POD-NLC, a kind of solution, created by our team (Gao et al, 2018). After signing the consent form, it was applied on the lesion ALA-PDT has been widely used for its advantage of low recurrence rate (Zhu et al, 2012). Dynamic monitoring of HPV genotypes and viral loads is helpful to guide PDT treatment and indicates the efficacy in eliminating HPV .…”

Anogenital warts – the new treatment options

“…Za typy onkogenne uznaje się HPV 16,18,[31][32][33][34][35]39, 42, 51-54. Wykazano, że znaczna część nowotworów występujących w okolicy anogenitalnej ma ścisły zwią-zek z infekcjami HPV.…”

“…W piśmiennictwie pojawiają się doniesienia o skuteczności terapii fotodynamicznej z zastosowaniem kwasu 5-aminolewulinowego (ALA) [31,32]. Opisywano zastosowanie tej metody zarówno w monoterapii, jak i w terapii skojarzonej z laseroterapią, łyżeczkowaniem i krioterapią.…”