Decreased 25-Hydroxyvitamin D Levels in Patients With Vestibular Neuritis

Abstract

Objective: Vestibular neuritis (VN) is characterized by acute onset of vertigo, nausea, and vomiting, without auditory or other neurological symptoms. Although the pathogenesis of VN is not yet clear, many studies have shown that a pro-inflammatory environment can lead to the induction and progression of the disease. Considering the importance of vitamin D in modulating the activation, proliferation, and differentiation of inflammatory physiological processes, we hypothesized that decreased serum vitamin D may be associated with the development of VN. In this study, we evaluated serum levels of 25-hydroxyvitamin D [25(OH)D] in patients presenting acutely with VN and healthy controls and investigated the possible correlation of serum 25(OH)D levels with VN. Methods: A total of 59 consecutive patients diagnosed with VN within 7 days of symptom onset and 112 age- and sex-matched healthy controls referred to Hwa Mei Hospital, University of Chinese Academy of Science, between March 2017 and March 2019 were recruited. Demographic and clinical data, such as age, sex, height, weight, living habits, ongoing health problems, and medication history, for all subjects were recorded, and levels of 25(OH)D were measured and compared. Results: Serum levels of 25(OH)D were lower in patients with VN than in controls (19.01 ± 6.53 vs. 22.94 ± 6.74 ng/ml, p < 0.001). Patients with VN had a higher frequency of vitamin D deficiency (61.0 vs. 34.8%, P = 0.001) than did controls. Regression analyses demonstrated that vitamin D deficiency was associated with VN, with an odds ratio of 4.53 (95% CI = 1.342–15.279, P = 0.015). Conclusion: This prospective study is the first to evaluate serum 25(OH)D levels in patients with VN and found that decreased serum 25(OH)D may be associated with VN occurrence.

The spectrum of acute vestibular neuropathy through modern vestibular testing: A descriptive analysis

“…In support of this conjecture were an early study that failed to demonstrate the efficacy of antiviral therapy (valacyclovir) in acute VN ( Strupp et al, 2004 ),the finding of elevated pro inflammatory components in the peripheral blood in the acute stage of VN ( Fattori et al, 2003 , Kassner et al, 2011 ),and some evidence of positive effect of corticosteroids ( Solis et al, 2019 ). Taking these into account, some authors postulate an immune mediated injury as the main mechanism of AVN ( Wu et al, 2019 ).…”

Vitamin D deficiency in benign paroxysmal positional vertigo

“…D 3 , обладая гормоноподобными свойствами, проявляет доказанную иммуномодулирующую активность, что влияет как на аутоиммунные заболевания (рассеянный склероз) [22], так и на сосудистые заболевания (болезнь малых сосудов головного мозга) [23]. В настоящее время ряд авторов полагают, что влияние дефицита D 3 на ДППГ, вестибулярный нейронит и некоторые другие состояния обусловлено его иммуномодулирующей функцией [24,25]. Однако проведенное исследование взаимосвязи ДППГ и недостаточности витамина D, где группой контроля для пациентов с ДППГ стали пациенты с другими нейровестибулярными нарушениями с преобладанием периферических нарушений (вестибулярный нейронит, болезнь Меньера, периферическая вестибулопатия), показало, что уровень D 3 достоверно ниже среди пациентов с ДППГ, чем в группе контроля [26].…”