Decreased Adrenal Sensitivity to ACTH in the Vasopressin-Deficient (Brattleboro) Rat

Wiley, M. Kathleen; Pearlmutter, A. Frances; Miller, Ralph E.

doi:10.1159/000122269

Cited by 65 publications

(22 citation statements)

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“…However, this explanation cannot explain the lack of difference in corticosterone in the face of different ACTH concentrations in the studies that incorporated serial blood sampling. Enhanced adrenal gland sensitivity to ACTH could have provided a simple explanation; however, a decreased adrenal sensitivity to ACTH in di/di animals was observed and is also supported by previous in vitro (Wiley et al 1974) and in vivo (Brudieux et al 1986) studies. Similar dissociations were Figure 6 Sensitivity of the anterior pituitary to CRH.…”

Section: Discussionsupporting

confidence: 75%

The stimuli-specific role of vasopressin in the hypothalamus–pituitary–adrenal axis response to stress

Zelena

Domokos

Jain

et al. 2009

Journal of Endocrinology

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Adaptation to a constantly changing environment is fundamental to every living organism. The hypothalamicpituitary-adrenocortical (HPA) axis is a key component of the adaptation process. The present study tests the hypothesis that vasopressin (AVP) is required for the HPA response to acute stimuli. To accomplish this, naturally AVP-deficient Brattleboro rats were exposed to a wide range of stimuli and their HPA response was compared with heterozygous littermattes. The circadian rhythmicity of plasma ACTH and corticosterone was not different between the two genotypes. The ACTH and corticosterone response to volume load, restraint or aggressive attack were decreased in AVP-deficient rats. The stress-induced increase in ACTH, but not corticosterone, was significantly impaired in AVPdeficient animals after novelty, elevated plus-maze, forced swim, hypoglycaemia, ulcerogenic cold immobilisation, lipopolysaccharide, hypertonic saline and egg white injection. The HPA response to social avoidance, ether inhalation and footshock was not different between the genotypes. In vitro, the hypophysis of AVP-deficient animals showed a reduction in stimulated ACTH production and their adrenal glands were hyporeactive to ACTH. A dissociation between the ACTH and corticosterone response was observed in several experiments and could not be explained by an earlier ACTH peak or enhanced adrenal sensitivity, suggesting the existence of paraadenohypophyseal neuroendocrine regulators. Loss of AVP affected the HPA response to a wide variety of stressors. Interestingly, the contribution of AVP to the HPA response was not specific for, nor limited to, a known stressor category. Thus, there is a context-specific requirement for AVP in stress-induced activation of the HPA axis.

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Section: Discussionsupporting

confidence: 75%

The stimuli-specific role of vasopressin in the hypothalamus–pituitary–adrenal axis response to stress

Zelena

Domokos

Jain

et al. 2009

Journal of Endocrinology

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“…Impairment of stress responses has been reported by McCann et al [9], Yates et al [30] and Wiley et al [28], while normal functions were observed by Arimura et al [3]. A reduced adrenal response to ACTH in HO-DI rats has also been found [28]. However, the present experiments suggest that impairment of the pituitary-adrenal response in HO-DI rats may pnmarily depend on a disturbance in the psychological response to stress.…”

Section: Discussionsupporting

confidence: 54%

“…Several authors have investigated the pituitary-adrenal function of HO-DI rats. Impairment of stress responses has been reported by McCann et al [9], Yates et al [30] and Wiley et al [28], while normal functions were observed by Arimura et al [3]. A reduced adrenal response to ACTH in HO-DI rats has also been found [28].…”

Section: Discussionmentioning

confidence: 87%

Behavioral and endocrine responses of rats with hereditary hypothalamic diabetes insipidus (Brattleboro strain)

Bohus

Greidanus

Wied

1975

Physiology & Behavior

165

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BOHUS, B., Tj. B. VAN WIMERSMA GREIDANUS AND D. DE WIED. Behavioral and endocrine responses of rats with hereditary hypothalamic diabetes insipidus (Brattleboro strain). PHYSIOL. BEHAV. 14(5) [609][610][611][612][613][614][615] 1975. -Behavioral and endocrine profiles were established of homozygous (HO-DI) and heterozygous (HE-DI) rats with hereditary hypothalamic diabetes insipidus in comparison to Wistar strain rats. HO-DI rats were inferior m acquiring and maintaining active and passive avoidance behavior. Behavioral deficits were most obwous in a step-through one-trial learning passive avoidance test and least in multiple trial one way active avoidance test. Plasma eortieosterone levels determined after the retention test appeared to be closely related to the passive avoidance behavior of the HO-DI rats. Passive avoidance immediately after the single learning trial was associated with elevated plasma corticosterone level; absence of avoidance and absence in plasma cortieosterone elevation was observed 24 hr after learning. These observations are compatible with the hypothesis that vasopressin is involved in the consolidation and/or retrieval of learned responses. Differences between HO-DI and Wistar rats m open field behavior, in response threshold to electric footshock, and in a number of somatic endocrine parameters are reported and discussed. Hereditary hypothalamlc diabetes msipidusVasopressln Shuttle box avoidance Pole jumping avoidance Step-through passive avoidance Plasma corticosterone response Open field Footshock responsiveness Body growth Hypophysis Adrenal Testis VASOPRESSIN or antidiuretic hormone (ADH) of posterior pituitary origin plays an important role in the organization of adaptive behavior. Removal of the posterior lobe of the pituitary gland interferes with the maintenance of a shuttle box avoidance response in the rat which can be restored by treatment with pitressin or lysine-8-vasopressin (LVP) [21]. Impaired acquisition of a similar avoidance response which occurs after hypophysectomy is ameliorated by LVP [ 6]. In the intact rat the same preparations increase resistance to extinction of both a shuttle box and pole jumping avoidance response [23,24,29] and facilitate passive avoidance behavior [2,5]. These behavioral effects of vasopressin are of a long term nature and last much longer than can be accounted for by the actual presence of the peptide in the organism [6,23,24]. The effect of vasopressin on behavior is not due to its classical endocrine activities. Desglycinamide-8-1yslne vasopressin (DG-LVP), a peptide isolated from hog pituitary material which lacks almost all antidiuretic and pressor activities [26], also stimulates avoidance acquisition in hypophysectomized rats [8], increases resistance to extinction of a pole jumping avoidance response [26], and improves passive avoidance retention in the intact rat [15]. These 609 observations together with those showing similar behavioral effects of intracerebrally and peripherally administered LVP [29] led to the hypothesis th...

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“…A spontaneous point mutation resulted in an altered AVP precursor which was unable to enter the secretory pathway (Evans et al, 2000, Surget andBelzung, 2008). As a result, homozygous AVP-deficient Brattleboro rats (KO) show diminished HPA axis responses to different acute stressors (Wiley et al, 1974, Conte-Devolx et al, 1982, Fink et al, 1992, accompanied by reduced depressive-and anxiety-like behavioral profile (Mlynarik et al, 2007). More specifically, AVP-deficient rats showed higher preference for a sweet solution, spent considerably shorter time immobile in the FS test and less time self-grooming on the elevated plus maze (EPM) accompanied by a higher level of dexamethasone-induced suppression of corticosterone response to restraint stress.…”

mentioning

confidence: 99%

Restoration of peripheral V2 receptor vasopressin signaling fails to correct behavioral changes in Brattleboro rats

Balázsfi

Pintér

Klausz

et al. 2015

Psychoneuroendocrinology

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Short title:Stress-related behavior in Brattleboro rat after DDAVP treatment You created this PDF from an application that is not licensed to print to novaPDF printer (http://www.novapdf.com) Balázsfi et al. 2Highlights  The effect of AVP on affective and memory symptoms is due to its central role  DDAVP treatment compensated the peripheral effects of congenital AVP absence  DDAVP did not significantly alter the behavior of KO animals in the paradigms tested  AVP signaling in the medial amygdala contributes to the behavioral effect measured in FS AbstractBeside its hormonal function in salt and water homeostasis, vasopressin -released into distinct brain areas -plays a crucial role in stress-related behavior resulting in the enhancement of an anxious/depressive-like state.We aimed to investigate whether correction of the peripheral symptoms of congenital absence of AVP also corrects the behavioral alterations in AVP-deficient Brattleboro rats. Wild type (WT) and vasopressin-deficient (KO) male Brattleboro rats were tested.Half of the KO animals were treated by desmopressin (V2-receptor agonist) via osmotic minipump (subcutaneous) to eliminate the peripheral symptoms of vasopressin-deficiency. Anxiety was studied by elevated plus maze (EPM), defensive withdrawal (DW) and marble burying (MB) tests, while depressive-like changes were monitored in forced swimming (FS) and anhedonia by sucrose preference test. Cell activity was examined in septum and amygdala by c-Fos immunohistochemistry after 10min FS.

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Decreased Adrenal Sensitivity to ACTH in the Vasopressin-Deficient (Brattleboro) Rat

Cited by 65 publications

References 4 publications

The stimuli-specific role of vasopressin in the hypothalamus–pituitary–adrenal axis response to stress

The stimuli-specific role of vasopressin in the hypothalamus–pituitary–adrenal axis response to stress

Behavioral and endocrine responses of rats with hereditary hypothalamic diabetes insipidus (Brattleboro strain)

Restoration of peripheral V2 receptor vasopressin signaling fails to correct behavioral changes in Brattleboro rats

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