Decreased anti-Müllerian hormone concentration in follicular fluid of female smokers undergoing artificial reproductive techniques

Fuentes, Ariel; Muñoz, Alex; Pommer, Ricardo; Arguello, Begoña; Galleguillos, A.; Torres, Andrea; Jesam, C.

doi:10.1016/j.chemosphere.2012.02.054

Cited by 14 publications

(14 citation statements)

References 14 publications

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“…Some studies report associations with lower AMH (16, 17, 19–21) and some do not (6, 8, 9, 18, 22). Most prior studies have dichotomized tobacco smoking as ever/never or categorized as current/former/never.…”

Section: Discussionmentioning

confidence: 99%

Antimüllerian hormone in relation to tobacco and marijuana use and sources of indoor heating/cooking

White

Sandler

D’Aloisio

et al. 2016

Fertility and Sterility

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Objective To evaluate exposure to tobacco, marijuana and indoor heating/cooking sources in relation to anti-Müllerian hormone (AMH) levels. Design Cross-sectional analysis in a sample of premenopausal women (N=913) enrolled in the Sister Study cohort (n=50,884). Setting U.S. adult sample Patient(s) Women, 35–54 at time of enrollment, with an archived serum sample, at least 1 intact ovary, and classified as premenopausal. Intervention(s) Not applicable Main Outcome Measures Serum AMH (ng/ml) levels ascertained by ultrasensitive ELISA assay Results Lower AMH levels were associated with sources of indoor heating, including burning wood (−36.0%, 95%CI:−55.7, −7.8%) or artificial firelogs (−45.8%, 95%CI:−67.2, −10.4) at least 10 times/year in a residential indoor stove/fireplace. Lower AMH levels were also observed in women who were current smokers of ≥20 cigarettes/day relative to non-smokers (−56.2%, 95%CI:−80.3, −2.8%) and in women with 10+ years of adult environmental tobacco smoke (ETS) exposure (−31.3%, 95%CI:−51.3, −3.1%) but no associations were observed for marijuana use. Conclusions We confirmed previously reported findings of lower AMH levels in current heavy smokers and also found associations for long-term ETS exposure and indoor burning of wood or artificial firelogs. These findings suggest that combustion by-products from common exposures can have toxic effects on the human ovary.

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Section: Discussionmentioning

confidence: 99%

Antimüllerian hormone in relation to tobacco and marijuana use and sources of indoor heating/cooking

White

Sandler

D’Aloisio

et al. 2016

Fertility and Sterility

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“…Nuestros resultados avalan la asociación del hábito de fumar con una caída de las concentraciones de AMH reportada por otros autores 10,11,12 . Igualmente importante, estos resultados demuestran que AMH es un marcador de reserva ovárica que tiende a disminuir a medida que la mujer envejece y es sensible a factores ambientales.…”

Section: Discussionunclassified

El hábito de fumar se asocia a baja concentración plasmática de hormona antimülleriana en mujeres infértiles

et al. 2013

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“…Studies on pre-menopausal women demonstrated that smoking was not associated to non-growing follicle (NGF) (primordial, intermediate, and primary follicles) count [46], and, in line with results on peri-menopausal women, was associated to increased FSH levels, but not to AMH levels [47], suggesting that a direct role in antral follicle atresia might be questionable. Studies on women enrolled in ART are controversial in this regards; indeed, no difference in AMH levels and in small AFC was reported in smokers by one study [48], although different studies showed either decreased AMH levels and altered follicles size repartition in AFC [49], or decreased follicular fluid AMH levels [50], highlighting the need of further dedicated studies. Experimental studies on ovarian cells retrieved from women undergoing ART demonstrated that a major ovotoxic action of smoking is oxidative stress and DNA damage in granulosa cells, which might interfere with cell maturation, binding of gonadotropins to their receptors, and oocyte fertilizing capacity [18,51].…”

Section: Ovarian Reservementioning

confidence: 98%

Smoke, alcohol and drug addiction and female fertility

Angelis

Nardone

Garifalos

et al. 2020

Reprod Biol Endocrinol

105

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Background: Considerable interest has been gathered on the relevant impact of preventable factors, including incorrect lifestyle and unhealthy habits, on female fertility. Smoking, alcohol and addictive drugs consumption represent a major concern, given the broad range of diseases which might be favored or exacerbated by these dependable attitudes. Despite the well-characterized effects of prenatal exposure on pregnancy outcomes and fetus health, a substantial proportion of women of reproductive age is still concerned with these habits. At present, the impact of smoke, alcohol and addictive drugs on women fertility, and, particularly, the specific targets and underlying mechanisms, are still poorly understood or debated, mainly due to the scarcity of well-designed studies, and to numerous biases. Objective: The current review will provide a comprehensive overview of clinical and experimental studies in humans and animals addressing the impact of smoke, alcohol and addictive drugs on female fertility, by also embracing effects on ovary, oviduct, and uterus, with particular reference to primary endpoints such as ovarian reserve, steroidogenesis, ovulation and menstrual cycle, oviduct function and uterus receptivity and implantation. A brief focus on polycystic ovary syndrome and endometriosis will be also included. Methods: A Pubmed literature search was performed with selected keywords; articles were individually retrieved by each author. No limitation was set for publication date. Articles in languages other than English were excluded. Additional articles were retrieved from references list of selected manuscripts. Results and conclusions: Currently, the most consistent evidences of a detrimental effect of smoke, alcohol and addictive drugs on specific domains of the female reproductive function are provided by experimental studies in animals. Overall, clinical studies suggest that smoking is associated to decreased fertility, although causal inference should be further demonstrated. Studies addressing the effect of alcohol consumption on female fertility provide conflicting results, although the majority reported lack of a correlation. Extremely scarce studies investigated the effects of addictive drugs on female fertility, and the specific actions of selected drugs have been difficult to address, due to multidrug consumption.

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Decreased anti-Müllerian hormone concentration in follicular fluid of female smokers undergoing artificial reproductive techniques

Cited by 14 publications

References 14 publications

Antimüllerian hormone in relation to tobacco and marijuana use and sources of indoor heating/cooking

Antimüllerian hormone in relation to tobacco and marijuana use and sources of indoor heating/cooking

El hábito de fumar se asocia a baja concentración plasmática de hormona antimülleriana en mujeres infértiles

Smoke, alcohol and drug addiction and female fertility

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