Decreased Apolipoprotein C-III Concentration in the High-Density Lipoprotein Fraction from Calves Inoculated with Pasteurella haemolytica and Bovine Herpes Virus-1

Yamamoto, Midori; Katoh, Norio

doi:10.1292/jvms.62.49

Cited by 8 publications

(13 citation statements)

References 21 publications

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“…The significantly lower levels of PON-1 and HDL and the higher level of VLDL in calves affected by inflammatory conditions confirms that also in calves HDL decreases early during inflammation, as previously suggested (Yamamoto et al, 2000) and in agreement with what reported in other species (Carpentier and Scruel, 2002;Khovidhunkit et al, 2004). This decrease may be detected using both the methods employed in this study for measuring HDLs.…”

Section: Accepted Manuscriptsupporting

confidence: 91%

Colorimetric and electrophoretic evaluation of lipoprotein fractions in healthy neonatal calves: Comparison with results from adult cows and from calves with inflammatory conditions

Giordano

Rossi

Probo

et al. 2017

Research in Veterinary Science

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT A C C E P T E D M A N U S C R I P T 2 AbstractHigh density lipoproteins (HDLs) are pivotal in innate immunity and decrease in serum during inflammation. Several studies have been done about lipoprotein changes in transition cows but little is known about their changes in newborn calves. The aim of this study is to provide information about HDLs in newborn calves, by defining the possible age-related changes in healthy calves compared with adults and by assessing the possible differences in calves with inflammation.Lipoprotein electrophoretic separation (reported as percentages) and colorimetric measurement of HDL (HDL-C) were performed on healthy cows and calves in order to identify possible differences in the lipoprotein profile due to the age. Then, age-matched calves with inflammatory conditions were also evaluated. Results showed that in calves HDL% and VLDL% were lower (mean values ± SD: 77.6% ± 8.6% and 2.6% ± 2.5%, respectively) and LDL% was higher (19.7% ± 7.4%) than in adults (89.0% ± 3.9%; 5.2 ± 2.1% and 5.8% ± 3.1%, respectively). Sick calves revealed a decrease of both HDL% (mean values ± SD: 61.0% ± 22.1%) and HDL-C (22.8 ± 11.6 mg/dL) and an increase of VLDL% (12.1% ±13.1%) compared with controls (77.6% ± 8.6%; 41.5 ± 11.2 mg/dL and 2.6% ± 2.5%, respectively). Paraoxonase-1 activity, influenced by inflammation and oxidation, was measured, and it appeared correlated with HDL% and HDL-C in sick calves. In conclusion, this study revealed that HDLs concentration in healthy calves is lower than in adults, and further decreases in calves with inflammation, likely due to oxidation.. Keywords:High density lipoproteins; Calf; Inflammation; Paraoxonase-1; Electrophoresis. ACCEPTED MANUSCRIPTA C C E P T E D M A N U S C R I P T 3 Highlights: Electrophoretic and colorimetric lipoprotein measurement were performed in calves  Good correlation between the two methods was found  Healthy calves showed lower HDL% and VLDL% and higher LDL% compared to adult cows  HDL decreases early during inflammation in sick calves  PON-1 activity was positively correlated with HDL-C in both sick and healthy calves ACCEPTED MANUSCRIPT

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Section: Accepted Manuscriptsupporting

confidence: 91%

Colorimetric and electrophoretic evaluation of lipoprotein fractions in healthy neonatal calves: Comparison with results from adult cows and from calves with inflammatory conditions

Giordano

Rossi

Probo

et al. 2017

Research in Veterinary Science

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“…The value during midlactation is comparable to the reported concentration in humans [68,99,133]. ApoC-III concentrations in 2-to 3-month-old male Holstein calves [188] and Japanese black calves [193] were in the range of 20 to 40 µg/ml and were lower than those in Holstein dairy cows. The apoC-III concentration was decreased in Holstein calves with pneumonia [188], whereas greatly increased in a Japanese black calf with hyperlipidemia [193].…”

Section: Apolipoproteinssupporting

confidence: 82%

“…Except for the calf with hyperlipidemia (higher concentration in the CM than HDL fraction) [193], the predominant distribution in HDL does not change in pathologic states such as calf pneumonia [188] and cow ketosis and milk fever [192]. The low apoC-III concentration in CM appears to be due to the indistinct alimentary lipemia [144].…”

Section: Apolipoproteinsmentioning

confidence: 99%

Relevance of Apolipoproteins in the Development of Fatty Liver and Fatty Liver-Releted Peripartum Diseases in Dairy Cows.

2002

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ABSTRACT. Most metabolic diseases in dairy cows occur during the peripartum period and are suggested to be derived from fatty liver initially developed during the nonlactating stage. Fatty liver is induced by hepatic uptake of nonesterified fatty acids that are released in excess by adipose tissues attributable to negative energy balance. The fatty accumulation leads to impairment of lipoprotein metabolism in the liver, and the impairment in turn influences other metabolic pathways in extrahepatic tissues such as the steroid hormone production by the corpus luteum. Detailed understanding of the impaired lipoprotein metabolism is crucial for elucidation of the mechanistic bases of the development of fatty liver and fatty liver-related peripartum diseases. This review summarizes results on evaluation of lipoprotein lipid and protein concentrations and enzyme activity in cows with fatty liver and those with ketosis, left displacement of the abomasum, milk fever, downer syndrome and retained placenta. Obtained data strongly suggest that decreases in serum concentrations of apolipoprotein B-100, apolipoprotein A-I and apolipoprotein C-III, a reduction in activity of lecithin:cholesterol acyltransferase and induction of haptoglobin and serum amyloid A are intimately related to the development of fatty liver and fatty liver-related diseases. Moreover, determination of the apolipoprotein concentrations and enzyme activity during the peripartum period is useful for early diagnoses of these diseases. KEY WORDS: apolipoprotein, bovine, estrogen receptor, fatty liver, protein kinase C.J. Vet. Med. Sci. 64(4): 293-307, 2002 PREFACE AND SCOPE OF THIS REVIEW Control of metabolic diseases, including ketosis, left displacement of the abomasum (LDA), milk fever and downer cow syndrome are crucially important for modern dairy husbandry, because their occurrence is intimately related to extensive feeding and management of dairy cows and also because high-yielding cows are particularly susceptible to such diseases. Affected cows, even after recovery from those metabolic diseases, have high incidences of reproductive and infectious diseases. Most metabolic diseases occur during the peripartum period (2 to 4 weeks from parturition) and are suggested to be caused by fatty liver (hepatic lipidosis) initially developed during the nonlactating stage. Fatty liver is a condition in which triglycerides (TG) accumulate in the liver. As a logical consequence, the TG accumulation results in impaired metabolism of lipoproteins, most of which are produced by the liver. Lipoproteins have a role in the transport of lipids between the liver and extrahepatic tissues. Impairment of lipoprotein metabolism is linked to disturbances of other metabolic pathways in extrahepatic tissues, for example, the steroid hormone production in the corpus luteum. Studies on impaired lipoprotein metabolism are therefore prerequisite to elucidate the mechanistic bases of the development of fatty liver and fatty liver-related diseases. Lipoproteins consist of lipids a...

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“…The total plasma apoC-III concentration increases in hypertriglyceridemia [4], suggesting the involvement of apoC-III in the regulation of TG metabolism. By comparison, except for a calf with hyperlipidemia [23], most apoC-III in normolipidemic cattle is detected in HDL [5,19,20,22]. The redistribution by feeding from HDL to the CM and VLDL fractions is not observed [20].…”

Section: Discussionmentioning

confidence: 99%

Concentrations of Apolipoprotein C-III in Healthy Cows during the Peripartum Period and Cows with Milk Fever.

Katoh

Nakagawa-Ueta²

2001

J. Vet. Med. Sci.

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ABSTRACT. Apolipoprotein (apo) C-III is a low-molecular-mass protein mainly distributed in the high-density lipoprotein fraction in cattle serum. We have recently shown that the apoC-III concentration is decreased in cows with fatty liver, ketosis, left displacement of the abomasum, retained placenta and milk fever. The decrease was most distinct in milk fever, thereby suggesting that apoC-III is particularly relevant to the development of milk fever and also that apoC-III is a candidate diagnostic marker for this disease. The purpose of the present study was to examine whether the apoC-III concentration in healthy cows is altered during the peripartum period, to assess the usefulness of apoC-III as a marker for milk fever. ApoC-III concentrations in 17 cows were monitored during the peripartum period (-48 to +12 days from parturition). Of the 17 cows, 14 were apparently healthy during the period. The apoC-III concentrations in the 14 healthy cows were unaltered during the period from -48 to -21 days, but thereafter showed individual variations. Compared with values during the period from -48 to -21 days, the apoC-III concentration was increased (137%) in 5 cows during the period from +1 to +12 days, whereas it decreased (60.7%) in 9 cows. Three cows suffered from milk fever at -3 to +10 days. Decreased apoC-III concentrations in diseased cows (15 to 37% of controls) were more distinct than in the 9 healthy cows. The apoC-III concentration was correlated with lecithin:cholesterol acyltransferase activity in cows with milk fever, but not in healthy cows. Correlation analysis also indicated that apoC-III and apoB-100 concentrations were negatively correlated in 5 healthy cows with increased apoC-III concentrations, but positively in 9 healthy cows with decreased concentrations and cows with milk fever. Determination of the apoC-III concentration during the peripartum period is suggested to be helpful in diagnosing milk fever. The possible relevance of apoC-III and apoB-100 in the development of milk fever is also implied. KEY WORDS: apoB-100, apoC-III, bovine, milk fever, peripartum period.J. Vet. Med. Sci. 63(6): 597-601, 2001 Most metabolic diseases of dairy cows develop in the peripartum period, during which the transition from the pregnant, nonlactating state to the nonpregnant, lactating state occurs [1]. The periparturient metabolic diseases include ketosis, left displacement of the abomasum, retained placenta and milk fever. Such diseases are suggested to be derived from fatty liver developed during the nonlactating stage [9,16]. The major biochemical characteristics of cows with fatty liver and fatty liver-related diseases are decreases in lipoprotein lipid and apoprotein concentrations. Thus far, decreases in concentrations of apolipoprotein (apo) B-100 [6,8,15,17], apoA-I [8, 14, 15, 17] and cholesteryl esters (CE) [10][11][12]18] and a reduction in activity of lecithin:cholesterol acyltransferase (LCAT) [10][11][12]18] have been used in diagnosing fatty liver and fatty liverrelated diseases.ApoC-III ...

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Decreased Apolipoprotein C-III Concentration in the High-Density Lipoprotein Fraction from Calves Inoculated with Pasteurella haemolytica and Bovine Herpes Virus-1

Cited by 8 publications

References 21 publications

Colorimetric and electrophoretic evaluation of lipoprotein fractions in healthy neonatal calves: Comparison with results from adult cows and from calves with inflammatory conditions

Colorimetric and electrophoretic evaluation of lipoprotein fractions in healthy neonatal calves: Comparison with results from adult cows and from calves with inflammatory conditions

Relevance of Apolipoproteins in the Development of Fatty Liver and Fatty Liver-Releted Peripartum Diseases in Dairy Cows.

Concentrations of Apolipoprotein C-III in Healthy Cows during the Peripartum Period and Cows with Milk Fever.

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