Decreased Apoptosis and Increased Activation of Alveolar Neutrophils in Bacterial Pneumonia

Droemann, Daniel; Aries, Sven Philip; Hansen, F; Moellers, M.; Braun, J.; Katus, Hugo A.; Dalhoff, K

doi:10.1378/chest.117.6.1679

Cited by 54 publications

(46 citation statements)

References 20 publications

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“…These observations are in keeping with studies showing reduced apoptosis of blood and bronchoalveolar lavage neutrophils in acute lung inflammation, such as respiratory distress syndrome, pneumonia [25,26] and exacerbations of bronchiectasis [27]. Future studies are needed to investigate the effects of COPD exacerbations on airway neutrophil survival.…”

Section: Discussionsupporting

confidence: 82%

Airway neutrophilia in COPD is not associated with increased neutrophil survival

Rytilä

Plataki²,

Bucchieri³

et al. 2006

Eur Respir J

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Neutrophilic airway inflammation is a prominent feature of chronic obstructive pulmonary disease (COPD) and correlates with disease severity. The mechanisms that determine the extent of neutrophilia could involve increased influx or prolonged survival of neutrophils. The aim of the study was to assess whether neutrophil pro-survival mechanisms are increased in the airways of subjects with COPD owing to the presence of anti-apoptotic factors in the bronchial lining fluid.Induced sputum samples were collected from 20 subjects with stable COPD, 14 healthy smokers and 14 healthy controls. Quantification of apoptotic neutrophils was based on typical morphological cell changes. Anti-apoptotic, pro-survival activity in the sputum was studied by culturing peripheral blood neutrophils with the fluid phase of induced sputum. Apoptosis was assessed both by morphology and flow cytometry using Annexin V/7-aminoactinomycin D staining.COPD patients and healthy smokers had significantly higher percentages of sputum neutrophils than healthy controls. However, there were no significant differences between the three subject groups in either the proportion of apoptotic neutrophils in sputum or the in vitro antiapoptotic activity detected in the sputum fluid phase.In conclusion, prolonged survival of neutrophils in sputum is not a feature of chronic obstructive pulmonary disease and cannot explain the increased numbers of airway neutrophils in this disease.

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Section: Discussionsupporting

confidence: 82%

Airway neutrophilia in COPD is not associated with increased neutrophil survival

Rytilä

Plataki²,

Bucchieri³

et al. 2006

Eur Respir J

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“…These authors also indicate other steps that must be explored to understand all the process, but they were not the objective of our present work. DROEMANN et al [8] have results in concordance with ours, and the differences in the rate of neutrophil apoptosis are probably due to the initial phase of pneumonia (24 h).…”

supporting

confidence: 90%

Chest radiotherapy to achieve lung volume reduction

Murray¹,

Lyons²

2012

Eur Respir J

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“…Delayed apoptosis of activated granulocytes has been reported to occur in a number of inflammatory conditions in humans or animal models, 5,52 including rheumatoid arthritis, 53 acute pancreatitis, 54 bacterial pneumonia, 55 inflammatory bowel disease, 56 asthma, [57][58][59] and following surgery. 60,61 Failure of these cells to undergo programmed cell death and to be cleared by phagocytes allows persistent and inappropriate inflammation to occur, as activated granulocytes release a number of proinflammatory mediators, which may contribute significantly to the aetiology of the disease.…”

Section: In Vivo Effects Of No and Its Therapeutic Potentialmentioning

confidence: 99%

Nitric oxide: a key regulator of myeloid inflammatory cell apoptosis

et al. 2003

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Apoptosis of inflammatory cells is a critical event in the resolution of inflammation, as failure to undergo this form of cell death leads to increased tissue damage and exacerbation of the inflammatory response. Many factors are able to influence the rate of apoptosis in neutrophils, eosinophils, monocytes and macrophages. Among these is the signalling molecule nitric oxide (NO), which possesses both anti-and proapoptotic properties, depending on the concentration and flux of NO, and also the source from which NO is derived. This review summarises the differential effects of NO on inflammatory cell apoptosis and outlines potential mechanisms that have been proposed to explain such actions.

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Decreased Apoptosis and Increased Activation of Alveolar Neutrophils in Bacterial Pneumonia

Cited by 54 publications

References 20 publications

Airway neutrophilia in COPD is not associated with increased neutrophil survival

Airway neutrophilia in COPD is not associated with increased neutrophil survival

Chest radiotherapy to achieve lung volume reduction

Nitric oxide: a key regulator of myeloid inflammatory cell apoptosis

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