Decreased apoptosis of bone marrow progenitor cells in HIV-1-infected patients during highly active antiretroviral therapy

Isgrò, Antonella; Mezzaroma, Ivano; Aiuti, Alessandro; Fantauzzi, Alessandra; Cossarizza, Andrea; Aiuti, F

doi:10.1097/00002030-200406180-00013

Cited by 15 publications

(15 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…20,21 One possible mechanism for this effect is an increase in Fas-mediated apoptosis of CD34 ϩ progenitor cells in the bone marrow due to HIV-1 infection resulting in loss of progenitor cells, which can be remedied with HAART. 20 Similar results have been seen in HIV-infected chimpanzees. 21 Research in the United States using HIV-1-infected and -uninfected human bone marrow found an association with CD34/CD4 ϩ % in the bone marrow and circulating CD4 counts.…”

Section: Figsupporting

confidence: 71%

Effects of HIV Type 1 Infection on Hematopoiesis in Botswana

Redd

Avalos²,

Phiri

et al. 2007

AIDS Research and Human Retroviruses

View full text Add to dashboard Cite

Clinical observations suggest that HIV-1 infection causes higher anemia rates in patients in southern Africa than in those in the United States. To explore this difference we performed a cross-sectional exploratory study on the effect of HIV-1 infection on hematopoiesis in Botswana by examining hematological presentation, HIV disease state, hematopoietic progenitor cell number, and circulating viral levels in HIV-infected patients and HIV-uninfected controls. We found significant associations between CD34(+) and CD4(+) cell counts in HIV-positive patients. Significant relationships were also seen between the CD34(+) CD4(+) cell population and hemoglobin levels, as well as colony-forming ability. These associations, however, were not seen in uninfected controls. Circulating viral p24 levels were found to correlate significantly with CD34(+) cell count, CD34(+) CD4(+) cell count, and colony-forming ability. These results demonstrate a direct association between HIV-1 infection in southern Africa and hematopoietic progenitor cell health.

show abstract

Section: Figsupporting

confidence: 71%

Effects of HIV Type 1 Infection on Hematopoiesis in Botswana

Redd

Avalos²,

Phiri

et al. 2007

AIDS Research and Human Retroviruses

View full text Add to dashboard Cite

show abstract

“…25,29,30 Work by multiple groups has shown that hematopoietic function can be at least partially restored with the use of highly active antiretroviral therapy (HAART). [31][32][33][34][35][36][37] The findings described here indicate that HIV-1C can infect HPC-CFUs and CD34 ϩ HPCs in vitro and in vivo, and that this infection is associated with higher anemia rates in infected patients. Taken with our previous results, this indicates that the effect of Data are numbers of infected colonies over numbers of single colonies tested.…”

Section: Discussionmentioning

confidence: 97%

Infection of hematopoietic progenitor cells by HIV-1 subtype C, and its association with anemia in southern Africa

Redd

Avalos²,

Essex

2007

Blood

View full text Add to dashboard Cite

Reports from southern Africa, an area in which human immunodeficiency virus type 1 (HIV-1) infection is caused almost exclusively by subtype C (HIV-1C), have shown increased rates of anemia in HIV-infected populations compared with similar acquired immunodeficiency syndrome (AIDS) patients in the United States, an area predominantly infected with subtype B (HIV-1B). Recent findings by our group demonstrated a direct association between HIV-1 infection and hematopoietic progenitor cell health in Botswana. Therefore, using a single-colony infection assay and quantitative proviral analysis, we examined whether HIV-1C could infect hematopoietic progenitor cells (HPCs) and whether this phenotype was associated with the higher rates of anemia found in southern Africa. The results show that a significant number of HIV-1C, but not HIV-1B, isolates can infect HPCs in vitro (P < .05). In addition, a portion of HIV-1C–positive Africans had infected progenitor cell populations in vivo, which was associated with higher rates of anemia in these patients (P < .05). This represents a difference in cell tropism between 2 geographically separate and distinct HIV-1 subtypes. The association of this hematotropic phenotype with higher rates of anemia should be considered when examining anti-HIV drug treatment regimens in HIV-1C–predominant areas, such as southern Africa.

show abstract

“…10 The introduction of highly active antiretroviral therapy (HAART) regimens in the mid-1990s dramatically changed many aspects of living with HIV infection, including drastic improvements in hematopoiesis. 11 Although HAART clearly ameliorates HIVassociated hematosuppression, blood cell development is not completely restored. 12 Moreover, long-term toxicity concerns are spurring the idea of moving treatment away from drug therapy.…”

Section: Introductionmentioning

confidence: 99%