2000
DOI: 10.1016/s0140-6736(00)03206-2
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Decreased atopy in children infected with Schistosoma haematobium: a role for parasite-induced interleukin-10

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Cited by 631 publications
(487 citation statements)
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“…It has become evident that something is lacking from our affluent societies that has the capacity to protect against the development of atopic (and autoimmune) diseases (102) Growing up on a farm may confer protection against atopy (114) Exposure to pets (cats and dogs) in early life may confer protection against atopy (123) 2000 Exposure to LPS in home dust may confer protection against atopy (93) Exposure to helminths may confer protection Current hygiene hypothesis; against the expression of atopic disease (134) Orofecal and helminth infections, 2001…”
Section: Resultsmentioning
confidence: 99%
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“…It has become evident that something is lacking from our affluent societies that has the capacity to protect against the development of atopic (and autoimmune) diseases (102) Growing up on a farm may confer protection against atopy (114) Exposure to pets (cats and dogs) in early life may confer protection against atopy (123) 2000 Exposure to LPS in home dust may confer protection against atopy (93) Exposure to helminths may confer protection Current hygiene hypothesis; against the expression of atopic disease (134) Orofecal and helminth infections, 2001…”
Section: Resultsmentioning
confidence: 99%
“…Parasitic infections appeared to be the major factor explaining this difference. A protective role by intestinal parasitic (helminth) infection against the development of allergic diseases has been reported by several studies (132)(133)(134)(135)(136), although some authors have reported an opposite result (137,138). The evidence of an inverse relationship between helminths and atopic disease applies mostly to asthma, whereas for e.g.…”
Section: Von Hertzen and Haahtelamentioning
confidence: 99%
See 1 more Smart Citation
“…The ability of IL-10 to then inhibit the release of histamine and other mediators by cord blood mast cells (Royer et al 2001) could therefore be the mechanism behind the inhibition of the skin prick test reaction in schistosomiasis. A study evaluating children living in an endemic area of S. haematobium in Africa showed high levels of IL-10 and a decreased skin prick tests response suggesting that IL-10 may be involved in that process (van den Biggelaar et al 2000). Therefore, we hypothesised that IL-10, produced during S. mansoni infection, down regulates the immediate immune response in atopic individuals by inhibiting IL-4 and IL-5 production.…”
Section: Influence Of Parasite Infection On the Devel-opment Of Allermentioning
confidence: 98%
“…Studying the mechanisms behind the protection against allergy, Araujo et al (2004) found that interleukin (IL-10) seems to play an important role in modulating the Th2 inflammatory response involved in the pathology of allergic diseases. Supporting this idea, Bigellar et al showed high levels of this cytokine in individuals infected with S. haematobium who did not respond to skin test to aeroallergens (van den Biggelaar et al 2000).It is well known that the acute phase of S. mansoni infection is characterized by a strong Th1 inflammatory response that evolues to a parasite antigen-driven Th2 response cronically . It is also known that this down modulation is mediated by S. mansoni antigen-driven IL-10 production .…”
mentioning
confidence: 97%