Decreased behavioral activation following caffeine, amphetamine and darkness in A3 adenosine receptor knock-out mice

Björklund, Olga; Halldner, Linda; Yang, Jiangning; Eriksson, Therése; Jacobson, Marlene A.; Daré, Elisabetta; Fredholm, Bertil B.

doi:10.1016/j.physbeh.2008.09.018

Cited by 30 publications

(29 citation statements)

References 42 publications

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“…Similarly, an increased motor activity has been revealed in A 3 AR knockout (KO) mice (Björklund et al, 2008a). It was recently demonstrated that A 3 AR receptors are present in the nerve terminal and muscle cells at the neuromuscular junctions.…”

Section: A Central Nervous Systemmentioning

confidence: 90%

The A₃Adenosine Receptor: History and Perspectives

et al. 2014

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Section: A Central Nervous Systemmentioning

confidence: 90%

The A₃Adenosine Receptor: History and Perspectives

et al. 2014

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“…Another view on the role of adenosine A 3 receptors in hematopoiesis can be obtained when adenosine A 3 receptor knockout (A 3 AR KO) mice would be used, and the picture of hematopoiesis in the situation of the lack of the adenosine A 3 receptor would be put together. A 3 AR KO mice were indeed constructed, and several articles based on the use of these mice in experiments with nonhematological topics were published (e.g., [13][14][15]). The first study on A 3 AR KO mice aimed at hematological evaluations was performed quite recently in our laboratory, and results were published illustrating disorders in selected parameters of erythropoiesis and thrombopoiesis in these mice [16].…”

Section: Introductionmentioning

confidence: 99%

Lack of adenosine A3 receptors causes defects in mouse peripheral blood parameters

Höfer

Pospı́šil

Dušek

et al. 2014

Purinergic Signalling

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The role of the adenosine A 3 receptor in hematopoiesis was studied using adenosine A 3 receptor knockout (A 3 AR KO) mice. Hematological parameters of peripheral blood and femoral bone marrow of irradiated and untreated A 3 AR KO mice and their wild-type (WT) counterparts were investigated. Irradiation of the mice served as a defined hematopoiesis-damaging means enabling us to evaluate contingent differences in the pattern of experimentally induced hematopoietic suppression between the A 3 AR KO mice and WT mice. Defects were observed in the counts and/or functional parameters of blood cells in the A 3 AR KO mice. These defects include statistically significantly lower values of blood neutrophil and monocyte counts, as well as those of mean erythrocyte volume, mean erythrocyte hemoglobin, blood platelet counts, mean platelet volume, and plateletcrit, and can be considered to bear evidence of the lack of a positive role played by the adenosine A 3 receptor in the hematopoietic system. Statistically significantly increased values of the bone marrow parameters studied in A 3 AR KO mice (femoral bone marrow cellularity, granulocyte/macrophage progenitor cells, and erythrocyte progenitor cells) can probably be explained by compensatory mechanisms attempting to offset the disorders in the function of blood elements in these mice. The pattern of the radiation-induced hematopoietic suppression was very similar in A 3 AR KO mice and their WT counterparts.

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“…Thus, the concentrations of caffeine used in these two studies were several orders of magnitude higher than the concentration of caffeine attained in the plasma in humans by ingestion of moderate amounts of coffee, estimated to be 5-70 µM (see [5][6][7][8]). The only pharmacological action known for caffeine at the low micromolar range is the antagonism of adenosine receptors, namely adenosine A 1 and A 2A receptors [9,10], and possibly adenosine A 3 receptors [11]. Other effects, like inhibition of phosphodiesterases, intracellular calcium release and blockade of GABA A receptors, require higher concentrations of caffeine [10,12], although future studies still need to be carried out to either exclude or define the role of these putative targets in the central effects of caffeine.…”

Section: Introductionmentioning

confidence: 99%

Caffeine, Adenosine Receptors, and Synaptic Plasticity

Costenla

Cunha

Mendonça

2010

JAD

112

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Abstract. Few studies to date have looked at the effects of caffeine on synaptic plasticity, and those that did used very high concentrations of caffeine, whereas the brain concentrations attained by regular coffee consumption in humans should be in the low micromolar range, where caffeine exerts pharmacological actions mainly by antagonizing adenosine receptors. Accordingly, rats drinking caffeine (1 g/L) for 3 weeks, displayed a concentration of caffeine of circa 22 µM in the hippocampus. It is known that selective adenosine A1 receptor antagonists facilitate, whereas selective adenosine A2A receptor antagonists attenuate, long term potentiation (LTP) in the hippocampus. Although caffeine is a non-selective antagonist of adenosine receptors, it attenuates frequency-induced LTP in hippocampal slices in a manner similar to selective adenosine A2A receptor antagonists. These effects of low micromolar concentration of caffeine (30 µM) are maintained in aged animals, which is important when a possible beneficial effect for caffeine in age-related cognitive decline is proposed. Future studies will still be required to confirm and detail the involvement of A1 and A2A receptors in the effects of caffeine on hippocampal synaptic plasticity, using both pharmacological and genetic approaches.

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Decreased behavioral activation following caffeine, amphetamine and darkness in A3 adenosine receptor knock-out mice

Cited by 30 publications

References 42 publications

The A₃Adenosine Receptor: History and Perspectives

The A₃Adenosine Receptor: History and Perspectives

Lack of adenosine A3 receptors causes defects in mouse peripheral blood parameters

Caffeine, Adenosine Receptors, and Synaptic Plasticity

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Decreased behavioral activation following caffeine, amphetamine and darkness in A3 adenosine receptor knock-out mice

Cited by 30 publications

References 42 publications

The A3Adenosine Receptor: History and Perspectives

The A3Adenosine Receptor: History and Perspectives

Lack of adenosine A3 receptors causes defects in mouse peripheral blood parameters

Caffeine, Adenosine Receptors, and Synaptic Plasticity

Contact Info

Product

Resources

About

The A₃Adenosine Receptor: History and Perspectives

The A₃Adenosine Receptor: History and Perspectives