Decreased bone mineral density at the distal radius, but not at the lumbar spine or the femoral neck, in Japanese type 2 diabetic patients

Majima, T.; Komatsu, Yasato; Yamada, Tomomi; Koike, Yoichi; Shigemoto, Michika; Takagi, Chieko; Hatanaka, I; Nakao, Kazuwa

doi:10.1007/s00198-004-1786-z

Cited by 79 publications

(64 citation statements)

References 32 publications

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“…In addition, another possibilityis is that hypercholesterolemia itself might have been associated with higher bone turnover, and that reduced bone resorption found in our study might have only reflected the hypercholesterolemia improved by atorvastatin. Indeed, Koshiyama et al [25] have recently reported the possibility that hypercholesterolemia may be the main cause of abnormal bone metabolism in type 2 diabetes mellitus [26]. However, ∆NTx did not correlate with ∆TC, ∆TG, ∆LDL or ∆HDL in our study.…”

Section: Discussioncontrasting

confidence: 73%

Short-term Effects of Atorvastatin on Bone Turnover in Male Patients with Hypercholesterolemia

et al. 2007

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Abstract. No consensus has been reached on whether the 3-hydroxy 3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, known as statins, have beneficial effects on bone health. The purpose of our study was to evaluate the effects of atorvastatin on bone metabolism by means of measuring bone turnover markers in male patients with hypercholesterolemia both at diagnosis and prospectively after 3 months of treatment. Twenty-two Japanese male patients (mean age 62.36 ± 10.1 years) with untreated hypercholesterolaemeia were selected for this study. After 3-months treatment of atorvastatin, total cholesterol and low density lipoprotein cholesterol significantly decreased as expected (p<0.001 for both parameters). Bone-specific alkaline phosphatase (BAP) did not change significantly (p = 0.444). However, serum N-terminal telopeptide of type I collagen (NTx) significantly decreased by -19.86 ± 26.4% (p = 0.020). In addition, ∆NTx during the course of this study was negatively correlated with NTx at baseline (r = -0.645, p = 0.0008). Although there was a tendency of positive correlations of ∆NTx with ∆total cholesterol, ∆triglycerides, and ∆low density lipoprotein cholesterol, and of negative correlations of ∆NTx and ∆BAP with ∆high density lipoprotein cholesterol, none of them reached statistical significance. Our findings suggest that atorvastatin may have potentially beneficial effects on bone metabolism in patients with hypercholesterolemia mostly by reducing bone resorption rather than by stimulating bone formation. Further studies with more patients and longer duration are warranted to evaluate its effects, if any, on prevention of osteoporosis and subsequent fractures.

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Section: Discussioncontrasting

confidence: 73%

Short-term Effects of Atorvastatin on Bone Turnover in Male Patients with Hypercholesterolemia

et al. 2007

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“…Although the results remain somewhat controversial, [11][12][13], several studies found a more decreased BMD in patients with hypercholesterolemia [5] or a significant correlation between higher T-C and decreased BMD [6][7][8][9][10]. The possibility has been pointed out that hypercholesterolemia may be the main cause of abnormal bone metabolism in type 2 diabetes mellitus [5,27]. In addition, findings of an animal model study demonstrated that BMD was reduced in dyslipidemic mice [25].…”

Section: Discussionmentioning

confidence: 99%

Increased Bone Turnover in Patients with Hypercholesterolemia

et al. 2008

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Abstract. Osteoporosis has been linked with arteriosclerotic vascular diseases, suggesting that hypercholesterolemia or dyslipidemia may be a common pathogenetic factor underlying these diseases. However, little is known about the relationship between osteoporosis and hypercholesterolemia. The purpose of this study was, therefore, to investigate the effects of hypercholesterolemia upon bone metabolism, by measuring bone turnover markers in hypercholesterolemic patients. This study included 281 Japanese patients with hypercholesterolemia, and 267 control subjects. Serum bonespecific alkaline phosphatase (BAP) of the patients was significantly higher than that of the controls in women. Serum N-terminal telopeptide of type I collagen (NTx) of the patients was significantly higher than that of the controls in both men and women. In addition, both BAP and NTx in men showed a significantly negative correlation with high density lipoprotein cholesterol (HDL-C). On the other hand, in women, both BAP and NTx showed a significantly positive correlation with total cholesterol and low density lipoprotein cholesterol (LDL-C). These results indicate increased bone turnover in hypercholesterolemic or dyslipidemic patients regardless of gender, and suggest the importance of treating hypercholesterolemia or dyslipidemia in order to prevent not only arteriosclerotic complications but also osteoporotic bone loss and subsequent fractures.

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“…Indeed, whether lipids affect bone metabolism or not remains unclear thus far. However, Koshiyama et al [29] has recently reported the possibility that hypercholesterolemia may be the main cause of abnormal bone metabolism in type 2 diabetes mellitus [31]. In addition, both in vitro [32] and in vivo animal model studies [33] have also demonstrated some detrimental effects of lipids on bone metabolism.…”

Section: Discussionmentioning

confidence: 99%

Clinical Significance of 1-year Treatment with Raloxifene on Bone and Lipid Metabolism in Japanese Postmenopausal Women with Osteoporosis

et al. 2007

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Abstract. It has been well established that raloxifene (RLX) has beneficial effects on bone primarily in Caucasian women. However, to date, there is a dearth of data for Japanese postmenopausal women. In this study, we prospectively evaluated the effects of RLX on bone and lipid metabolism in fifty Japanese postmenopausal patients with untreated osteoporosis. We measured bone mineral density (BMD) by dual-energy X-ray absorptiometry at 7 sites including the lumbar spine, femoral neck, and distal radius. BMD was significantly increased at the lumbar spine both at 6 months and at 12 months compared with at baseline (p<0.01 for both), although the possibility could not be completely excluded that this increase may be partly explained by an apparent increase induced by degenerative changes in lumbar vertebrae since we had no control subjects to compare and be more certain of the findings in this study. Both bone-specific alkaline phosphatase (BAP) and serum N-terminal telopeptide of type I collagen (NTx) significantly decreased both at 6 months (p<0.01 for both) and at 12 months (p<0.01 for both) compared with at baseline, but not below the lower limit of the reference value. Total cholesterol and low-density lipoprotein cholesterol were significantly improved while triglycerides and high-density lipoprotein cholesterol were unaltered. Although longer and larger studies with fracture endpoints are needed to draw definite conclusions, our findings suggest the favorable effects of RLX on bone and lipid metabolism in Japanese postmenopausal women with osteoporosis as in Caucasian women.

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Decreased bone mineral density at the distal radius, but not at the lumbar spine or the femoral neck, in Japanese type 2 diabetic patients

Cited by 79 publications

References 32 publications

Short-term Effects of Atorvastatin on Bone Turnover in Male Patients with Hypercholesterolemia

Short-term Effects of Atorvastatin on Bone Turnover in Male Patients with Hypercholesterolemia

Increased Bone Turnover in Patients with Hypercholesterolemia

Clinical Significance of 1-year Treatment with Raloxifene on Bone and Lipid Metabolism in Japanese Postmenopausal Women with Osteoporosis

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