Decreased brain docosahexaenoic acid during development alters dopamine-related behaviors in adult rats that are differentially affected by dietary remediation

Levant, Beth; Radel, Jeffery D.; Carlson, Susan E.

doi:10.1016/j.bbr.2003.09.029

Cited by 62 publications

(59 citation statements)

References 73 publications

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“…In Experiment II the control diet and GABA containing diets contained palm oil that is poor in n-3 fatty acids. The tendency towards a decreased locomotion distance observed in the MF diet group compared with the control and GABA diet groups may be related to the suppression of a decline in memory associated with n-3 deficiency (Levant et al, 2004). In experiment I, the n-3 deficiency might occur in the three diet groups bediet groups at all time points.…”

Section: Locomotion Distancesmentioning

confidence: 74%

Effect of Extruded Polished, Brown, and Germinated Brown Rice on the Behavior and Plasma Parameters of ICR Mice

Shirai

Suzuki

et al. 2010

FSTR

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The purpose of this study was to investigate the effect of extruded polished rice (PR), brown rice (BR), and germinated brown rice (GBR) on the behavior of ICR mice in a repeated open field test, as well as their concentrations of plasma lipids, glucose, and minerals. After 4 weeks in the open field test, the locomotion distance was significantly lower in mice fed GBR than those fed PR, but showed no difference in mice fed a diet with the same gamma-aminobutyric acid (GABA) content as GBR. The different rice diets had little influence on plasma lipids and glucose but the plasma calcium content was significantly higher in mice fed BR than those fed PR. These results suggest that the influence of GBR on mice behavior may be related to other components of GBR in addition to GABA and that BR and GBR may have no negative influence on mineral levels.

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Section: Locomotion Distancesmentioning

confidence: 74%

Effect of Extruded Polished, Brown, and Germinated Brown Rice on the Behavior and Plasma Parameters of ICR Mice

Shirai

Suzuki

et al. 2010

FSTR

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“…Locomotor activity was increased in adult mice deprived of n-3 PUFAs over several generations (64), and in adult rats and mice whose mothers were deprived at conception or during gestation (65)(66)(67). Deprivation in a single generation did not alter locomotor activity (68), agreeing with our results.…”

Section: Discussionmentioning

confidence: 99%

One generation of n-3 polyunsaturated fatty acid deprivation increases depression and aggression test scores in rats

DeMar

Bell

et al. 2006

Journal of Lipid Research

224

157

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Male rat pups at weaning (21 days of age) were subjected to a diet deficient or adequate in n-3 polyunsaturated fatty acids (n-3 PUFAs) for 15 weeks. Performance on tests of locomotor activity, depression, and aggression was measured in that order during the ensuing 3 weeks, after which brain lipid composition was determined. In the n-3 PUFA-deprived rats, compared with n-3 PUFA-adequate rats, docosahexaenoic acid (22:6n-3) in brain phospholipid was reduced by 36% and docosapentaenoic acid (22:5n-6) was elevated by 90%, whereas brain phospholipid concentrations were unchanged. N-3 PUFA-deprived rats had a significantly increased (P 5 0.03) score on the Porsolt forcedswim test for depression, and increased blocking time (P 5 0.03) and blocking number (P 5 0.04) scores (uncorrected for multiple comparisons) on the isolation-induced residentintruder test for aggression. Large effect sizes (d . 0.8) were found on the depression score and on the blocking time score of the aggression test. Scores on the open-field test for locomotor activity did not differ significantly between groups, and had only small to medium effect sizes. This single-generational n-3 PUFA-deprived rat model, which demonstrated significant changes in brain lipid composition and in test scores for depression and aggression, may be useful for elucidating the contribution of disturbed brain PUFA metabolism to human depression, aggression, and bipolar disorder.-DeMar, J. C., Jr., K. Ma, J. M. Bell, M. Igarashi, D. Greenstein, and S. I. Rapoport. One generation of n-3 polyunsaturated fatty acid deprivation increases depression and aggression test scores in rats.

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“…3). Moreover, rodents subjected to diets deficient in DHA or its precursor show reduced attention and reduction in locomotor responses to novelty, habituation, and anxiety (4)(5)(6). n-3 PUFA-deficient animals also exhibit aggressive behavior and increased symptoms of depression in a forced swim test (7).…”

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confidence: 99%

n-3 Polyunsaturated fatty acid supplementation reverses stress-induced modifications on brain monoamine levels in mice

Vancassel

Leman

Hanonick

et al. 2008

Journal of Lipid Research

111

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The aim of this study was to examine the effects of supplementation with n-3 polyunsaturated fatty acids (PUFAs) on stress responses in mice subjected to an unpredictable chronic mild stress (UCMS) procedure. Stressinduced modifications in coat and aggressiveness were evaluated, and phospholipid PUFA profiles and monoamine levels were analyzed in the frontal cortex, hippocampus, and striatum. The results showed that repeated exposure to mild stressors induced degradation in the physical state of the coat, lowered body weight gain, and increased aggressiveness, without any effect of n-3 PUFA supplementation. The UCMS induced a significant decrease in the levels of norepinephrine in the frontal cortex and striatum, and a nonsignificant decrease in the hippocampus. The tissue levels of serotonin (5-HT) were 40% to 65% decreased in the three brain regions studied. Interestingly, the n-3 PUFA supplementation reversed this stressinduced reduction in 5-HT levels. These findings showed that supplementation in n-3 long-chain PUFAs might reverse certain effects of UCMS in cerebral structures involved in stress-related behaviors.-Vancassel, S., S. Leman, L. Hanonick, S. Denis, J. Roger, M. Nollet, S. Bodard, I. Kousignian, C. Belzung, and S. Chalon. n-3 Polyunsaturated fatty acid supplementation reverses stress-induced modifications on brain monoamine levels in mice. J. Lipid Res. 2008. 49: 340-348.

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Decreased brain docosahexaenoic acid during development alters dopamine-related behaviors in adult rats that are differentially affected by dietary remediation

Cited by 62 publications

References 73 publications

Effect of Extruded Polished, Brown, and Germinated Brown Rice on the Behavior and Plasma Parameters of ICR Mice

Effect of Extruded Polished, Brown, and Germinated Brown Rice on the Behavior and Plasma Parameters of ICR Mice

One generation of n-3 polyunsaturated fatty acid deprivation increases depression and aggression test scores in rats

n-3 Polyunsaturated fatty acid supplementation reverses stress-induced modifications on brain monoamine levels in mice

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