Decreased brain FDG uptake in patients with extensive non-Hodgkin’s lymphoma lesions

Abstract

Demonstrating a significant negative correlation between TGV and brain uptake validated the phenomenon of decreased brain FDG uptake. Diversion of FDG from the brain to the lymphoma tissue may occur during the FDG accumulation process. Recognition of this phenomenon prevents unnecessary further neurological examinations in such cases.

Metabolic Activity of Red Nucleus and Its Correlation with Cerebral Cortex and Cerebellum: A Study Using a High-Resolution Semiconductor PET System

“…This is the first investigation of regional cerebral glucose metabolism using our semiconductor PET system. The mean global SUV in the present study population was 6.3 6 1.4 and showed slightly larger variations than the previously reported values obtained with conventional clinical whole-body PET scanners (18,19). The larger variations may have been due to the heterogeneity of our study group, which consisted of head and neck cancer carriers, or to the sensitivity profile of the semiconductor scanner, which is slightly different from that of the clinical system (11,12).…”

“…In the present study, the subjects were placed in a dim room during the uptake of 18 F-FDG, whereas in the investigation by Nioche et al the study subjects were asked to close their eyes during MR scanning. In general, fMRI has higher temporal resolution and thus can visualize rapid changes in regional blood flow, whereas 18 F-FDG PET measures glucose metabolism averaged over a postinjection period. However, unlike other MR imaging techniques, the blood oxygenation level-dependent fMRI is significantly limited by poor spatial resolution, low signal levels and contrast, and image artifacts (20).…”

“…However, unlike other MR imaging techniques, the blood oxygenation level-dependent fMRI is significantly limited by poor spatial resolution, low signal levels and contrast, and image artifacts (20). 18 F-FDG PET is a feasible method for steady-state evaluation under a resting condition, because it is more independent from the imaging conditions and physical stimuli (e.g., environmental noise, light, and anxiety), which may temporally activate regional brain function. Therefore, the concordance between the present PET results and their fMRI findings may suggest a role of RNs in higher brain functions in addition to the known link with the rubrospinal tract to control muscular structures (21).…”

“…During the brain resting state, the RN displayed strong functional coherence with associative prefrontal, insular, temporal, and parietal cortices; the thalamus; and the hypothalamus but not with the sensorimotor cortex (5). 18 F-FDG PET has been used for correlational analyses of regional metabolic rates to characterize relations among different brain regions (6,7). In general, regional functional correlation of the resting brain can be better demonstrated with 18 F-FDG PET than with MR imaging.…”

“…18 F-FDG PET has been used for correlational analyses of regional metabolic rates to characterize relations among different brain regions (6,7). In general, regional functional correlation of the resting brain can be better demonstrated with 18 F-FDG PET than with MR imaging. However, because the low spatial resolution of the clinical PET or PET/CT system has not allowed accurate measurement of metabolism in small structures, the metabolic activity of RN has not been investigated in detail.…”