Decreased cerebral cortex and liver 5-HT<sub>2A</sub>receptor gene expression and enhanced ALDH activity in ethanol-treated rats and hepatocyte cultures

George, Akash K.; Paul, Jes; Kaimal, S. Balarama; Paulose, C S

doi:10.1179/174313209x385554

Cited by 8 publications

(6 citation statements)

References 19 publications

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“…Thus, 5-HT may play an important role in addiction [71]. Previous studies have revealed that addictive behavior with alcohol [72] and pathological gambling [73] are associated with lower 5-HT levels. In addition, several studies have reported that light exposure increases blood 5-HT levels in a specific brain region in humans and rats [74][75][76][77].…”

Section: Discussionmentioning

confidence: 99%

The Mediating Effect of Eveningness on the Indirect Relationships between Shorter Sleep Duration, Inattention, Depression with Smartphone Addiction Tendency

et al. 2020

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Objective: Smartphones make our lives more convenient. To investigate the relationships between sleep-related habits, inattention, and smartphone addiction tendency (SAT), we determined how chronotype (morningness-eveningness) mediates these factors in Korean college students. Methods: Self-rated questionnaires including the Morningness-Eveningness Questionnaire, Smartphone Addiction Scale-Short Version, Adult Attention Deficit and Hyperactivity Disorder Scale, and Hospital Anxiety and Depression Scale were administered to 1,060 Korean college student smartphone users. This study investigated associations between sleep-related habits, social jetlag, inattention, anxiety, depression and SAT. A path analysis was conducted to evaluate the relationships, considering chronotype. Results: More social jetlag and smartphone use before bedtime had both direct and indirect relationships with SAT via eveningness in the path analysis model. Participants with shorter exposure to sunlight and more anxiety symptoms had a direct relationship with SAT. Individuals with a depressed mood, shorter sleep duration, and more inattentive features had no significant direct relationship with SAT but they had a significant indirect relationship with SAT via eveningness. Conclusion: The findings support the idea that chronotype plays a significant mediating role as a predictor of smartphone addiction. Managing modifiable variables and social jetlag as well as other clinical variables may help prevent and treat smartphone addiction in clinical practice.

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Section: Discussionmentioning

confidence: 99%

The Mediating Effect of Eveningness on the Indirect Relationships between Shorter Sleep Duration, Inattention, Depression with Smartphone Addiction Tendency

et al. 2020

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“…This stress treatment also decreases the level of serotonin and its metabolites in frontal cortex and striatum (Ahmad et al, 2010). On top of these effects, repeated binge drinking exacerbates the increase of extracellular glutamate levels while further reducing brain serotonin levels (George et al, 2010; Szumlinski et al, 2007). Antagonizing NMDA receptors and type I metabotropic glutamatergic receptors had been shown to ameliorate the impact on synaptic structure induced by chronic unpredictable stress (Li et al, 2011) and reduce binge intake (Cozzoli et al, 2012; Cozzoli et al, 2014; Lum et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Combined Effects of Acamprosate and Escitalopram on Ethanol Consumption in Mice

Qiu

Jia

et al. 2016

Alcohol Clin Exp Res

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Background Major depression is one of the most prevalent psychiatry comorbidities of alcohol use disorders (AUD). Since negative emotions can trigger craving and increase the risk of relapse, treatments that target both conditions simultaneously may augment treatment success. Previous studies showed a potential synergist effect of FDA approved medication for AUD acamprosate and the antidepressant escitalopram. In this study, we investigated the effects of combining acamprosate and escitalopram on ethanol consumption in stress-induced depressed mice. Methods Forty singly-housed C57BL/6J male mice were subjected to chronic unpredictable stress. In parallel, 40 group-housed male mice were subjected to normal husbandry. After 3 weeks, depressive- and anxiety-like behaviors and ethanol consumption were assessed. For the next 7 days, mice were injected with saline, acamprosate (200 mg/kg; twice/day), escitalopram (5 mg/kg; twice/day), or their combination (n = 9–11/drug group/stress group). Two-bottle choice limited access drinking of 15% ethanol and tap water was performed 3 hours into dark phase for 2 hours immediately after the dark phase daily injection. Ethanol drinking was monitored for another 7 days without drug administration. Results Mice subjected to the chronic unpredictable stress paradigm for 3 weeks showed apparent depression- and anxiety-like behaviors compared to their non-stressed counterparts including longer immobility time in the forced swim test and lower sucrose preference. Stressed mice also displayed higher ethanol consumption and preference in a 2-bottle choice drinking test. During the drug administration period, the escitalopram-only and combined drug groups showed significant reduction in ethanol consumption in non-stressed mice, while only the combined drug group showed significantly reduced consumption in stressed mice. However, such reduction did not persist into the post-drug administration period. Conclusions The combination of acamprosate and escitalopram suppressed ethanol intake in both non-stressed and stressed mice, hence this combination is potentially helpful for AUD individuals with or without comorbid depression to reduce alcohol use.

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“…However, both studies had small sample sizes, and thus the divergent results might come from their limited power. Future studies of this polymorphism and the presence of the alcohol dependence remain an interesting focus for investigations, especially in light of the recent findings that decreased 5-HT function mediated through 5-HT2A receptors has been reported to elevate aldehyde dehydrogenase (ALDH) activity in the brain stem of alcohol treated rats and in vitro hepatocyte cultures (George et al, 2010). …”

Section: Discussionmentioning

confidence: 99%

Association of polymorphisms in HTR2A, HTR1A and TPH2 genes with suicide attempts in alcohol dependence: A preliminary report

Wrzosek

Łukaszkiewicz

Serafin

et al. 2011

Psychiatry Research

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We investigated a relationship between selected polymorphisms: rs6313 in HTR2A, rs6295 in HTR1A and rs1386494 in TPH2, and suicidal behavior in 150 alcohol-dependent patients. There was a significant association between more frequent C102C genotype in HTR2A and suicide attempts in alcoholic females. No differences in genotype distribution in HTR1A and TPH2 SNPs were found between patients with and without suicide attempts.

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Decreased cerebral cortex and liver 5-HT_2Areceptor gene expression and enhanced ALDH activity in ethanol-treated rats and hepatocyte cultures

Abstract: Our results suggest that the decreased serotonin function mediated through 5-HT(2A) receptors have a regulatory role on ALDH activity. This will have clinical significance to correct alcoholics from addiction due to allergic aldehyde accumulation.

Cited by 8 publications

References 19 publications

The Mediating Effect of Eveningness on the Indirect Relationships between Shorter Sleep Duration, Inattention, Depression with Smartphone Addiction Tendency

The Mediating Effect of Eveningness on the Indirect Relationships between Shorter Sleep Duration, Inattention, Depression with Smartphone Addiction Tendency

Combined Effects of Acamprosate and Escitalopram on Ethanol Consumption in Mice

Association of polymorphisms in HTR2A, HTR1A and TPH2 genes with suicide attempts in alcohol dependence: A preliminary report

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Decreased cerebral cortex and liver 5-HT2Areceptor gene expression and enhanced ALDH activity in ethanol-treated rats and hepatocyte cultures

Abstract: Our results suggest that the decreased serotonin function mediated through 5-HT(2A) receptors have a regulatory role on ALDH activity. This will have clinical significance to correct alcoholics from addiction due to allergic aldehyde accumulation.

Cited by 8 publications

References 19 publications

The Mediating Effect of Eveningness on the Indirect Relationships between Shorter Sleep Duration, Inattention, Depression with Smartphone Addiction Tendency

The Mediating Effect of Eveningness on the Indirect Relationships between Shorter Sleep Duration, Inattention, Depression with Smartphone Addiction Tendency

Combined Effects of Acamprosate and Escitalopram on Ethanol Consumption in Mice

Association of polymorphisms in HTR2A, HTR1A and TPH2 genes with suicide attempts in alcohol dependence: A preliminary report

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Decreased cerebral cortex and liver 5-HT_2Areceptor gene expression and enhanced ALDH activity in ethanol-treated rats and hepatocyte cultures