Decreased Cerebrospinal Fluid/Plasma Ratio of the Novel Satiety Molecule, Nesfatin-1/NUCB-2, in Obese Humans: Evidence of Nesfatin-1/NUCB-2 Resistance and Implications for Obesity Treatment

Tan, Bee K.; Hallschmid, Manfred; Kern, W.; Lehnert, Hendrik; Randeva, Harpal S.

doi:10.1210/jc.2010-1782

Cited by 96 publications

(77 citation statements)

References 19 publications

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“…As nesfatin-1 is expressed in human, acts as anorexigen, and its role has recently been suggested in many other functions such as, epilepsy and puberty onset, our data may be relevant regarding nesfatin-1, as a potential pharmacotherapeutical target. 7,39,40 …”

Section: Discussionmentioning

confidence: 99%

Nesfatin-1 exerts long-term effect on food intake and body temperature

Könczöl

Pintér²,

Ferenczi

et al. 2012

Int J Obes

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OBJECTIVE:To determine whether the anorexigenic peptide, nesfatin-1 affects energy expenditure, and to follow the time course of its effects. DESIGN: Food intake duration, core body temperature, locomotor activity and heart rate of rats were measured by telemetry for 48 h after a single intracerebroventricular injection of 25 or 100 pmol nesfatin-1 applied in the dark or the light phase of the day. Body weight, food and water intake changes were measured daily. Furthermore, cold-responsive nesfatin-1/NUCB2 neurons were mapped in the brain. RESULTS: Nesfatin-1 reduced duration of nocturnal food intake for 2 days independently of circadian time injected, and raised body temperature immediately, or with little delay depending on the dose and circadian time applied. The body temperature remained higher during the next light phases of the 48 h observation period, and the circadian curve of temperature flattened. After light phase application, the heart rate was elevated transiently. Locomotion did not change. Daily food and water intake, as well as body weight measurements point to a potential decrease in all parameters on the first day and some degree of compensation on the second day. Cold-activated (Fos positive) nesfatin-1/NUCB2 neurones have been revealed in several brain nuclei involved in cold adaptation. Nesfatin-1 co-localised with prepro-thyrotropin-releasing hormone in cold responsive neurones of the hypothalamic paraventricular nucleus, and in neurones of the nucleus raphe pallidus and obscurus that are premotor neurones regulating brown adipose tissue thermogenesis and skin blood flow. CONCLUSION: Nesfatin-1 has a remarkably prolonged effect on food intake and body temperature. Time course of nesfatin-1's effects may be varied depending on the time applied. Many of the nesfatin-1/NUCB2 neurones are cold sensitive, and are positioned in key centres of thermoregulation. Nesfatin-1 regulates energy expenditure a far more potent way than it was recognised before making it a preferable candidate anti-obesity drug.

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Section: Discussionmentioning

confidence: 99%

Nesfatin-1 exerts long-term effect on food intake and body temperature

Könczöl

Pintér²,

Ferenczi

et al. 2012

Int J Obes

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“…Nesfatin-1 is an 82-amino acid residue derived from the nucleobindin-2 (NUCB2) peptide, possibly through proteolysis by prohormone convertases (7). Nesfatin-1̸NUCB2 immunoreactive cells were found to be expressed in the pancreas, stomach, duodenum, adipose tissue, central amygdaloid nucleus, hypothalamus, nucleus accumbens, cerebellum and Effects of aging on the plasma levels of nesfatin-1 and adiponectin JIANG-BO LI 1,2 , MIYUKI NISHIDA 1 , KAORI KAIMOTO 1 , AKIHIRO ASAKAWA 1 , HUHE CHAOLU 1 , KAI-CHUN CHENG 1 , YING-XIAO LI 1 , MUTSUMI TERASHI 1 , KEN ICHIRO KOYAMA 1 , microdissected lumbar spinal cord in rodents, suggesting that nesfatin-1̸NUCB2 may be crucial in the physiological regulation of carbohydrate metabolism, gastrointestinal function and nutrient absorption (8)(9)(10)(11)(12)(13)(14). Furthermore, the nesfatin-1-induced inhibition of food intake may be mediated through the inhibition of orexigenic NPY neurons (15) and the activation of POMC and CART (16).…”

Section: Introductionmentioning

confidence: 99%

Effects of aging on the plasma levels of nesfatin-1 and adiponectin

Nishida

Kaimoto

et al. 2013

Biomedical Reports

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Abstract. Gastric and adipose tissue secrete a number of hormones that are involved in energy metabolism. The biological functions of these hormones, including their effects on aging, are currently under investigation. Adiponectin was shown to be directly involved in appetite and the control of body weight. However, the effects of aging of nesfatin-1, an appetite-suppressing peptide that was recently identified, have not yet been fully elucidated. The aim of this study was to determine the effects of aging on the plasma levels of nesfatin-1 and adiponectin. Our results demonstrated no significant differences in the nesfatin-1 plasma levels among three age groups (2, 6 and 24 months) of female BALB̸c mice. The plasma nesfatin-1 levels̸visceral fat (VF) ratio in the 24-month-old mice was significantly lower compared to that in the 2-and 6-month-old mice. In addition, there were no significant differences in the plasma adiponectin levels among the three age groups. The plasma adiponectin levels̸VF ratio in the 24-month-old mice was significantly lower compared to that in the 2-and 6-month-old mice. In conclusion, there were no age-related changes in the plasma levels of nesfatin-1 and adiponectin, although the ratio of plasma levels of nesfatin-1 and adiponectin per VF was decreased with advancing age. Our results indicated that nesfatin-1 and adiponectin may be involved in controlling energy balance during aging.

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“…The possible discrepancy in the production of nesfatin-1/NUCB-2, by these central neurons may account for the differences in CSF/plasma nesfatin-1/NUCB-2 ratio between obese and lean subjects observed by Tan et al (2011). Furthermore, it is probable that nesfatin-1/NUCB-2 has protein binding, and that differences in protein binding in obese and lean subjects may also explain these findings.…”

Section: Nesfatin-1 and Anti-obesitymentioning

confidence: 93%

“…Furthermore, it is probable that nesfatin-1/NUCB-2 has protein binding, and that differences in protein binding in obese and lean subjects may also explain these findings. Finally, it is possible that the efficiency of nesfatin-1/NUCB-2 uptake into CSF is reduced in obese individuals, possibly due to saturation of transporters (Tan et al, 2011). Further studies could be useful to elucidate this hypothesis.…”

Section: Nesfatin-1 and Anti-obesitymentioning

confidence: 99%

“…Nesfatin-1/NUCB-2 is colocalized with a number of hypothalamic peptides regulating food intake (Fort et al, 2008;Shimizu et al, 2009b;Maejima et al, 2009;Yoshida et al, 2010;Tan et al, 2011;Kerbel and Unniappan, 2012;GoebelStengel and Wang, 2013). Several interactions have been described to underlie the central anorexic effect of nesfatin-1 (Shimizu et al, 2009c).…”

Section: Nesfatin-1/nucb-2 and Anorexigenic Effectmentioning

confidence: 99%

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Nesfatin Role as Possible New Anti Obesity Treatment

Rossano¹

2014

J Obes Weight Loss Ther

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In this article, we review on the current concepts about Nesfatin-1 as a new anti-obesity treatment and evaluate the existing issues in the context of this knowledge and the available literature. The intent is to enable clinicians to know Nesfatin-1 as a new anti-obesity treatment and make rational decisions based on this perspective as possible clinical application. Future research should seek to clarify whether Nesfatin-1 would be beneficial in the management of obesity.

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Decreased Cerebrospinal Fluid/Plasma Ratio of the Novel Satiety Molecule, Nesfatin-1/NUCB-2, in Obese Humans: Evidence of Nesfatin-1/NUCB-2 Resistance and Implications for Obesity Treatment

Abstract: Our observations have important implications with respect to the potential weight-reducing actions of nesfatin-1/NUCB-2 treatment. Future research should seek to clarify whether nesfatin-1/NUCB-2 would be beneficial in the management of obesity.

Cited by 96 publications

References 19 publications

Nesfatin-1 exerts long-term effect on food intake and body temperature

Nesfatin-1 exerts long-term effect on food intake and body temperature

Effects of aging on the plasma levels of nesfatin-1 and adiponectin

Nesfatin Role as Possible New Anti Obesity Treatment

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